Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Katherine M. Sheu"'
Autor:
Bryan A. Smith, Nikolas G. Balanis, Avinash Nanjundiah, Katherine M. Sheu, Brandon L. Tsai, Qingfu Zhang, Jung Wook Park, Michael Thompson, Jiaoti Huang, Owen N. Witte, Thomas G. Graeber
Publikováno v:
Cell Reports, Vol 24, Iss 12, Pp 3353-3366.e5 (2018)
Summary: Cancer progression to an aggressive phenotype often co-opts aspects of stem cell biology. Here, we developed gene signatures for normal human stem cell populations to understand the relationship between epithelial cancers and stem cell trans
Externí odkaz:
https://doaj.org/article/941c3d3a58854d218e6a21f2ae06cbc8
Autor:
Stefanie Luecke, Xiaolu Guo, Katherine M Sheu, Apeksha Singh, Sarina C Lowe, Minhao Han, Jessica Diaz, Francisco Lopes, Roy Wollman, Alexander Hoffmann
Publikováno v:
Molecular Systems Biology, Vol 20, Iss 8, Pp 898-932 (2024)
Abstract Macrophages sense pathogens and orchestrate specific immune responses. Stimulus specificity is thought to be achieved through combinatorial and dynamical coding by signaling pathways. While NFκB dynamics are known to encode stimulus informa
Externí odkaz:
https://doaj.org/article/9506b4bcfb2c4ad79bdb71e36b4b87f4
Publikováno v:
Cell Systems. 14:180-195.e5
Autor:
Katherine M, Sheu, Alexander, Hoffmann
Publikováno v:
Annual review of immunology, vol 40, iss 1
Annu Rev Immunol
Annu Rev Immunol
Macrophages are first responders for the immune system. In this role, they have both effector functions for neutralizing pathogens and sentinel functions for alerting other immune cells of diverse pathologic threats, thereby initiating and coordinati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b02d31015f95b22f90cb962423be16d
https://escholarship.org/uc/item/37t3t019
https://escholarship.org/uc/item/37t3t019
Autor:
Yan Wang, Lily Guo, Xihui Yin, Ethan C. McCarthy, Mandy I. Cheng, Aline T. Hoang, Ho-Chung Chen, Anushi Y. Patel, Denise Allard Trout, Erin Xu, Natalie Yakobian, Willy Hugo, James F. Howard, Katherine M. Sheu, Alexander Hoffmann, Melissa G. Lechner, Maureen A. Su
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 119, iss 4
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America
Significance GBS and CIDP are autoimmune disorders of the PNS that can be debilitating and even life threatening. Current therapies, which include corticosteroids and intravenous gammaglobulin, have poorly defined mechanisms of action and are ineffec
Autor:
Sho Ohta, Adewunmi Adelaja, Alexander Hoffmann, Quen J. Cheng, Katherine M. Sheu, Brooks Taylor, Roberto Spreafico
Publikováno v:
Science (New York, N.Y.), vol 372, iss 6548
Timing cues epigenomic reprogramming Different temporal dynamics of activation of the transcription factor nuclear factor κB (NF-κB) can influence the inflammatory response of activated macrophages. Cheng et al. report a mechanism by which oscillat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1addf7fe5a56c9998e8784b81ffaf912
https://escholarship.org/uc/item/2xw511jm
https://escholarship.org/uc/item/2xw511jm
Autor:
Ameya Champhekar, Jennifer Tsoi, Thomas G. Graeber, Katherine M. Sheu, Davis Y. Torrejon, Gabriel Abril-Rodriguez, Cristina Puig-Saus, Alexander Hoffmann, Philip O. Scumpia, Catherine S. Grasso, Antoni Ribas, Egmidio Medina, Charles Swanton, Daniel E. Speiser, Yeon Joo Kim, Kevin Litchfield
Publikováno v:
J Clin Invest
Melanoma dedifferentiation has been reported to be a state of cellular resistance to targeted therapies and immunotherapies as cancer cells revert to a more primitive cellular phenotype. Here, we show that, counterintuitively, the biopsies of patient
Publikováno v:
Immunity
Immunity, vol 54, iss 9
Immunity, vol 54, iss 9
Immune sentinel cells initiate immune responses to pathogens and tissue injury and are capable of producing highly stimulus-specific responses. Insight into the mechanisms underlying such specificity has come from the identification of regulatory fac
Autor:
Brooks Taylor, Katherine M. Sheu, Alexander Hoffmann, Roberto Spreafico, Adewunmi Adelaja, Quen J. Cheng, Sho Ohta
SummaryThe epigenome defines the cell type, but also shows plasticity that enables cells to tune their gene expression potential to the context of extracellular cues. This is evident in immune sentinel cells such as macrophages, which can respond to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aca123f3a51340201d2b5b70848120a
Publikováno v:
Cell systems, vol 10, iss 2
Cell Syst
Cell Syst
Summary Pathogen-derived lipopolysaccharide (LPS) and cytokine tumor necrosis factor (TNF) activate NFκB with distinct duration dynamics, but how immune response genes decode NFκB duration to produce stimulus-specific expression remains unclear. He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13e029ba66cd115e74c86d89c0a3a788
https://escholarship.org/uc/item/9cg5z7sz
https://escholarship.org/uc/item/9cg5z7sz