Identification of benzopyrone as a common structural feature in compounds with anti-inflammatory activity in a zebrafish phenotypic screen

Autor: Anne L. Robertson, Nikolay V. Ogryzko, Katherine M. Henry, Catherine A. Loynes, Matthew J. Foulkes, Marco M. Meloni, Xingang Wang, Christopher Ford, Malcolm Jackson, Philip W. Ingham, Heather L. Wilson, Stuart N. Farrow, Roberto Solari, Roderick J. Flower, Simon Jones, Moira K. B. Whyte, Stephen A. Renshaw

Publikováno v: Disease Models & Mechanisms, Vol 9, Iss 6, Pp 621-632 (2016)

Neutrophils are essential for host defence and are recruited to sites of inflammation in response to tissue injury or infection. For inflammation to resolve, these cells must be cleared efficiently and in a controlled manner, either by apoptosis or r

Externí odkaz: https://doaj.org/article/a3fe65776cda4d07a4ea5faf6e7dcd33

Pioneer neutrophils release chromatin within in vivo swarms

Autor: Hannah M Isles, Catherine A Loynes, Sultan Alasmari, Fu Chuen Kon, Katherine M Henry, Anastasia Kadochnikova, Jack Hales, Clare F Muir, Maria-Cristina Keightley, Visakan Kadirkamanathan, Noémie Hamilton, Graham J Lieschke, Stephen A Renshaw, Philip M Elks

Publikováno v: eLife, Vol 10 (2021)

Neutrophils are rapidly recruited to inflammatory sites where their coordinated migration forms clusters, a process termed neutrophil swarming. The factors that modulate early stages of neutrophil swarming are not fully understood, requiring the deve

Externí odkaz: https://doaj.org/article/d4579f2c9a1845eca0b84e65f16d27ae

Functional drug screening reveals anticonvulsants as enhancers of mTOR‐independent autophagic killing of Mycobacterium tuberculosis through inositol depletion

Autor: Mark Schiebler, Karen Brown, Krisztina Hegyi, Sandra M Newton, Maurizio Renna, Lucy Hepburn, Catherine Klapholz, Sarah Coulter, Andres Obregón‐Henao, Marcela Henao Tamayo, Randall Basaraba, Beate Kampmann, Katherine M Henry, Joseph Burgon, Stephen A Renshaw, Angeleen Fleming, Robert R Kay, Karen E Anderson, Phillip T Hawkins, Diane J Ordway, David C Rubinsztein, Rodrigo Andres Floto

Publikováno v: EMBO Molecular Medicine, Vol 7, Iss 2, Pp 127-139 (2014)

Abstract Mycobacterium tuberculosis (MTB) remains a major challenge to global health made worse by the spread of multidrug resistance. We therefore examined whether stimulating intracellular killing of mycobacteria through pharmacological enhancement

Externí odkaz: https://doaj.org/article/ada27d1f952241569b2948040684763a

Pioneer neutrophils release chromatin within in vivo swarms

Autor: Clare F. Muir, Catherine A. Loynes, Sultan Alasmari, Noémie Hamilton, Jack Hales, Fu Chuen Kon, Stephen A. Renshaw, Anastasia Kadochnikova, Katherine M. Henry, Visakan Kadirkamanathan, Maria-Cristina Keightley, Hannah M. Isles, Philip M. Elks, Graham J. Lieschke

Publikováno v: eLife, Vol 10 (2021)
eLife

Neutrophils are rapidly recruited to inflammatory sites where their coordinated migration forms clusters, a process termed neutrophil swarming. The factors that modulate early stages of neutrophil swarming are not fully understood, requiring the deve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d0a7ef42032b06a37e1b03dd6013727
https://elifesciences.org/articles/68755

Inhibition of ErbB kinase signalling promotes resolution of neutrophilic inflammation

Autor: Hannah M. Isles, Annemarie H. Meijer, Julien Rougeot, Stephen A. Renshaw, Kathryn R. Higgins, Caroline Tabor, Claudia Tulotta, Moira K. B. Whyte, Abigail E Reese, Atiqur Rahman, Aar Thompson, Lynne R. Prince, Kimberly D Herman, Katherine M. Henry, David H. Dockrell, Nika Khoshaein, Caroline O. S. Savage, David Sammut, William J. Zuercher, Ian Sabroe

Publikováno v: eLife
eLife, 8, e50990
Rahman, A, Henry, K M, Herman, K D, Thompson, A A, Isles, H M, Tulotta, C, Sammut, D, Rougeot, J J, Khoshaein, N, Reese, A E, Higgins, K, Tabor, C, Sabroe, I, Zuercher, W J, Savage, C O, Meijer, A H, Whyte, M K, Dockrell, D H, Renshaw, S A & Prince, L R 2019, ' Inhibition of ErbB kinase signalling promotes resolution of neutrophilic inflammation ', eLIFE, vol. 8 . https://doi.org/10.7554/eLife.50990
eLife, Vol 8 (2019)

Neutrophilic inflammation with prolonged neutrophil survival is common to many inflammatory conditions, including chronic obstructive pulmonary disease (COPD). There are few specific therapies that reverse neutrophilic inflammation, but uncovering me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0b59e3fc62c3c598a92603ab84ee828
https://pubmed.ncbi.nlm.nih.gov/31613219