Zobrazeno 1 - 10
of 117
pro vyhledávání: '"Katherine M Hannan"'
Autor:
Louise E Kerry, Elaine E Pegg, Donald P Cameron, James Budzak, Gretchen Poortinga, Katherine M Hannan, Ross D Hannan, Gloria Rudenko
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 11, Iss 3, p e0005432 (2017)
Trypanosoma brucei relies on an essential Variant Surface Glycoprotein (VSG) coat for survival in the mammalian bloodstream. High VSG expression within an expression site body (ESB) is mediated by RNA polymerase I (Pol I), which in other eukaryotes e
Externí odkaz:
https://doaj.org/article/4a35b7495b2f4c1d877fe6f8ca6eb7b2
Autor:
Yeliz Boglev, Andrew P Badrock, Andrew J Trotter, Qian Du, Elsbeth J Richardson, Adam C Parslow, Sebastian J Markmiller, Nathan E Hall, Tanya A de Jong-Curtain, Annie Y Ng, Heather Verkade, Elke A Ober, Holly A Field, Donghun Shin, Chong H Shin, Katherine M Hannan, Ross D Hannan, Richard B Pearson, Seok-Hyung Kim, Kevin C Ess, Graham J Lieschke, Didier Y R Stainier, Joan K Heath
Publikováno v:
PLoS Genetics, Vol 9, Iss 2, p e1003279 (2013)
Ribosome biogenesis underpins cell growth and division. Disruptions in ribosome biogenesis and translation initiation are deleterious to development and underlie a spectrum of diseases known collectively as ribosomopathies. Here, we describe a novel
Externí odkaz:
https://doaj.org/article/f2b587b2488b4beba385b93b524c7da4
Autor:
Chang-Won Kang, Anneke C. Blackburn, Amos Hong Pheng Loh, Kuick Chick Hong, Jian Yuan Goh, Nadine Hein, Denis Drygin, Chris R. Parish, Ross D. Hannan, Katherine M. Hannan, Lucy A. Coupland
Publikováno v:
Biomedicines, Vol 11, Iss 4, p 1133 (2023)
The survival rate of patients with osteosarcoma (OS) has not improved over the last 30 years. Mutations in the genes TP53, RB1 and c-Myc frequently occur in OS and enhance RNA Polymerase I (Pol I) activity, thus supporting uncontrolled cancer cell pr
Externí odkaz:
https://doaj.org/article/828e24308c6e4101a33cd536ee4eaae4
Autor:
Elaine Sanij, Katherine M. Hannan, Jiachen Xuan, Shunfei Yan, Jessica E. Ahern, Anna S. Trigos, Natalie Brajanovski, Jinbae Son, Keefe T. Chan, Olga Kondrashova, Elizabeth Lieschke, Matthew J. Wakefield, Daniel Frank, Sarah Ellis, Carleen Cullinane, Jian Kang, Gretchen Poortinga, Purba Nag, Andrew J. Deans, Kum Kum Khanna, Linda Mileshkin, Grant A. McArthur, John Soong, Els M. J. J. Berns, Ross D. Hannan, Clare L. Scott, Karen E. Sheppard, Richard B. Pearson
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Acquired resistance limits the efficacy of PARP inhibitors (PARPi) in high grade serous ovarian cancer (HGSOC). Here, the authors show that inhibition of RNA polymerase I transcription using CX-5461 increases the therapeutic efficacy of PARPi and ove
Externí odkaz:
https://doaj.org/article/e147f3013f3440d1be5ac0b31368773d
Autor:
Pei Y. Liu, Andrew E. Tee, Giorgio Milazzo, Katherine M. Hannan, Jesper Maag, Sujanna Mondal, Bernard Atmadibrata, Nenad Bartonicek, Hui Peng, Nicholas Ho, Chelsea Mayoh, Roberto Ciaccio, Yuting Sun, Michelle J. Henderson, Jixuan Gao, Celine Everaert, Amy J. Hulme, Matthew Wong, Qing Lan, Belamy B. Cheung, Leming Shi, Jenny Y. Wang, Thorsten Simon, Matthias Fischer, Xu D. Zhang, Glenn M. Marshall, Murray D. Norris, Michelle Haber, Jo Vandesompele, Jinyan Li, Pieter Mestdagh, Ross D. Hannan, Marcel E. Dinger, Giovanni Perini, Tao Liu
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
MYCN amplification is common in neuroblastomas. Here, the authors identify a long noncoding RNA, lncNB1 in these cancers and show that it promotes tumorigenesis by binding to ribosomal protein, RPL35 to enhance E2F1 and DEPDC1B protein synthesis, whi
Externí odkaz:
https://doaj.org/article/6f4020351a1c40b79a768a93d42a3e69
Autor:
Richard B. Pearson, Ross D. Hannan, Grant A. McArthur, Ricky W. Johnstone, Sean O'Brien, Denis Drygin, Jian Kang, Elaine Sanij, Gretchen Poortinga, Megan J. Bywater, Jake Shortt, Amee J. George, Pui Yee Ng, Eric Kusnadi, Carleen Cullinane, Nadine Hein, Katherine M. Hannan, Jennifer R. Devlin
This figure shows supplementary data pertinent to Figure 1 including cell death, cell signalling and mRNA transcription analysis data.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f00c09f22ecead59d5a70462dd77357
https://doi.org/10.1158/2159-8290.22530959.v1
https://doi.org/10.1158/2159-8290.22530959.v1
Autor:
Grant A. McArthur, Ricky W. Johnstone, Richard B. Pearson, Ross D. Hannan, Scott W. Lowe, Mark J. Smyth, Jake Shortt, Katherine M. Hannan, Kelly Waldeck, Megan V. Astle, Kathryn M. Kinross, Megan J. Bywater, Christopher J. Chan, Michael Bots, Ralph K. Lindemann, Kym L. Stanley, Gretchen Poortinga, Meaghan Wall
PDF file - 209K, Everolimus is associated with changes to the immunophenotype. SF8: Continued daily dosing with everolimus results in cell cycle arrest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6de4de063207b160280602ee467eb4c9
https://doi.org/10.1158/2159-8290.22528520.v1
https://doi.org/10.1158/2159-8290.22528520.v1
Autor:
Grant A. McArthur, Ricky W. Johnstone, Richard B. Pearson, Ross D. Hannan, Scott W. Lowe, Mark J. Smyth, Jake Shortt, Katherine M. Hannan, Kelly Waldeck, Megan V. Astle, Kathryn M. Kinross, Megan J. Bywater, Christopher J. Chan, Michael Bots, Ralph K. Lindemann, Kym L. Stanley, Gretchen Poortinga, Meaghan Wall
PDF file - 1.1MB, Quantitation of SA-B-gal and immunostaining. SF10: Markers of senescence. SF11: Overall survival of mice transplanted with a p53 mutant lymphoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a480ed05c13d6c40e0ce2c86224a3976
https://doi.org/10.1158/2159-8290.22528517
https://doi.org/10.1158/2159-8290.22528517
Autor:
Grant A. McArthur, Ricky W. Johnstone, Richard B. Pearson, Ross D. Hannan, Scott W. Lowe, Mark J. Smyth, Jake Shortt, Katherine M. Hannan, Kelly Waldeck, Megan V. Astle, Kathryn M. Kinross, Megan J. Bywater, Christopher J. Chan, Michael Bots, Ralph K. Lindemann, Kym L. Stanley, Gretchen Poortinga, Meaghan Wall
PDF file - 28K, Primer sequences. ST2: Baseline characteristics of randomized mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49be6b6e8fabd814608a4db5e1fd3026
https://doi.org/10.1158/2159-8290.22528514.v1
https://doi.org/10.1158/2159-8290.22528514.v1
Autor:
Grant A. McArthur, Ricky W. Johnstone, Richard B. Pearson, Ross D. Hannan, Scott W. Lowe, Mark J. Smyth, Jake Shortt, Katherine M. Hannan, Kelly Waldeck, Megan V. Astle, Kathryn M. Kinross, Megan J. Bywater, Christopher J. Chan, Michael Bots, Ralph K. Lindemann, Kym L. Stanley, Gretchen Poortinga, Meaghan Wall
PDF file - 165K, Morphology of tumors. SF2: Everolimus restores B-cell development. SF3: B-cell precursors in the bone marrow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::097d0eeb07b98603628be7face8ca507
https://doi.org/10.1158/2159-8290.22528529
https://doi.org/10.1158/2159-8290.22528529