Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Katherine M Bell-McGuinn"'
Autor:
Junichiro Yuda, Christine Will, Darren C. Phillips, Linu Abraham, Cory Alvey, Abraham Avigdor, Wayne Buck, Lauren Besenhofer, Erwin Boghaert, Dong Cheng, Dan Cojocari, Kelly Doyle, T. Matthew Hansen, Kevin Huang, Eric F. Johnson, Andrew S. Judd, Russell A. Judge, John C. Kalvass, Aaron Kunzer, Lloyd T. Lam, Rachel Li, Ruth L. Martin, Anthony Mastracchio, Mike Mitten, Adam Petrich, Jin Wang, James E. Ward, Haichao Zhang, Xilu Wang, Johannes E. Wolff, Katherine M. Bell-McGuinn, Andrew J. Souers
Publikováno v:
Communications Medicine, Vol 3, Iss 1, Pp 1-14 (2023)
Abstract Background MCL-1 is a prosurvival B-cell lymphoma 2 family protein that plays a critical role in tumor maintenance and survival and can act as a resistance factor to multiple anticancer therapies. Herein, we describe the generation and chara
Externí odkaz:
https://doaj.org/article/a09a2953c50e4da8ad9915dfa149ffac
Autor:
Michiel S. van der Heijden, Thomas Powles, Daniel Petrylak, Ronald de Wit, Andrea Necchi, Cora N. Sternberg, Nobuaki Matsubara, Hiroyuki Nishiyama, Daniel Castellano, Syed A. Hussain, Aristotelis Bamias, Georgios Gakis, Jae-Lyun Lee, Scott T. Tagawa, Ulka Vaishampayan, Jeanny B. Aragon-Ching, Bernie J. Eigl, Rebecca R. Hozak, Erik R. Rasmussen, Meng Summer Xia, Ryan Rhodes, Sameera Wijayawardana, Katherine M. Bell-McGuinn, Amit Aggarwal, Alexandra Drakaki
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Identification of biomarkers to stratify patients who might benefit from treatment is needed to optimize targeted therapies. Here, based on an analysis of the RANGE trial (NCT02426125), the authors report potentially predictive biomarkers for surviva
Externí odkaz:
https://doaj.org/article/48cfab2e04994935a36166abe99febbf
Autor:
Josep Tabernero, Irene Braña, Maria Alsina, Jorge D. Gallo, Brett E. Houk, Lixin Han, Kristen J. Pierce, Gary Borzillo, Robert Millham, Susan S. Pandya, Eunice L. Kwak, James Spicer, Johanna Bendell, Julian R. Molina, Katherine M. Bell-McGuinn, Geoffrey I. Shapiro
Supplemental Table 7. Results of the pharmacodynamic analysis of tumor-associated biomarkers following treatment with PF-05212384
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b46c240c8b64ebf0330fc492627ae09
https://doi.org/10.1158/1078-0432.22456157
https://doi.org/10.1158/1078-0432.22456157
Autor:
George Coukos, Robert M. Hershberg, Alexander Malykhin, Carolyn K. McCourt, Katherine M. Bell-McGuinn, Gwenn-äel H. Danet-Desnoyers, Kristi L. Manjarrez, Heather A. Lankes, Joan L. Walker, Paula M. Fracasso, Carol A. Aghajanian, William E. Brady, Andrea Facciabene, Bradley J. Monk
Supplemental Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::691f9c0b5367f8a873e4f16442675c13
https://doi.org/10.1158/1078-0432.22465809
https://doi.org/10.1158/1078-0432.22465809
Autor:
George Coukos, Robert M. Hershberg, Alexander Malykhin, Carolyn K. McCourt, Katherine M. Bell-McGuinn, Gwenn-äel H. Danet-Desnoyers, Kristi L. Manjarrez, Heather A. Lankes, Joan L. Walker, Paula M. Fracasso, Carol A. Aghajanian, William E. Brady, Andrea Facciabene, Bradley J. Monk
Supplemental Figure 1 Species-specific activation of TLR8 by motolimod. Supplemental Figure 2 Full human immune cell reconstitution in NSG-HIS mice. Supplemental Figure 3 Response to PLD + motolimod is not schedule-sensitive in the NSG-HIS mouse. Sup
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a145752886ca2bebdedee7d35df25989
https://doi.org/10.1158/1078-0432.22465806
https://doi.org/10.1158/1078-0432.22465806
Autor:
George Coukos, Robert M. Hershberg, Alexander Malykhin, Carolyn K. McCourt, Katherine M. Bell-McGuinn, Gwenn-äel H. Danet-Desnoyers, Kristi L. Manjarrez, Heather A. Lankes, Joan L. Walker, Paula M. Fracasso, Carol A. Aghajanian, William E. Brady, Andrea Facciabene, Bradley J. Monk
Table S1. Subject demographics and baseline characteristics Table S2. Tumor response as assessed by RECIST 1.1 and biochemical response
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08c163c1dcb09220763276dc1eaa908c
https://doi.org/10.1158/1078-0432.22465800
https://doi.org/10.1158/1078-0432.22465800
Autor:
Josep Tabernero, Irene Braña, Maria Alsina, Jorge D. Gallo, Brett E. Houk, Lixin Han, Kristen J. Pierce, Gary Borzillo, Robert Millham, Susan S. Pandya, Eunice L. Kwak, James Spicer, Johanna Bendell, Julian R. Molina, Katherine M. Bell-McGuinn, Geoffrey I. Shapiro
Supplemental Table 6. Changes observed in metabolic biomarker levels following treatment with PF-05212384
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::517bb1bc2edce5bc332ca3b1b3d79d69
https://doi.org/10.1158/1078-0432.22456160.v1
https://doi.org/10.1158/1078-0432.22456160.v1
Autor:
Josep Tabernero, Irene Braña, Maria Alsina, Jorge D. Gallo, Brett E. Houk, Lixin Han, Kristen J. Pierce, Gary Borzillo, Robert Millham, Susan S. Pandya, Eunice L. Kwak, James Spicer, Johanna Bendell, Julian R. Molina, Katherine M. Bell-McGuinn, Geoffrey I. Shapiro
Supplemental Table 1. Additional study results on treatment-related adverse events at dose levels below the maximum tolerated dose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::126227ee45601a14d10657779d0ada10
https://doi.org/10.1158/1078-0432.22456175.v1
https://doi.org/10.1158/1078-0432.22456175.v1
Autor:
Josep Tabernero, Irene Braña, Maria Alsina, Jorge D. Gallo, Brett E. Houk, Lixin Han, Kristen J. Pierce, Gary Borzillo, Robert Millham, Susan S. Pandya, Eunice L. Kwak, James Spicer, Johanna Bendell, Julian R. Molina, Katherine M. Bell-McGuinn, Geoffrey I. Shapiro
Supplemental Table 3. Cycle 1 results of the pharmacokinetic analysis of PF-05212384 administered at the maximum tolerated dose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72f79cf89011c4a0210cc955c3f4cde0
https://doi.org/10.1158/1078-0432.22456169.v1
https://doi.org/10.1158/1078-0432.22456169.v1
Autor:
Josep Tabernero, Irene Braña, Maria Alsina, Jorge D. Gallo, Brett E. Houk, Lixin Han, Kristen J. Pierce, Gary Borzillo, Robert Millham, Susan S. Pandya, Eunice L. Kwak, James Spicer, Johanna Bendell, Julian R. Molina, Katherine M. Bell-McGuinn, Geoffrey I. Shapiro
Supplemental Table 2. Additional study results on treatment-related adverse events at dose levels above the maximum tolerated dose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77c79d3f495a242cc7fefed02ad412ef
https://doi.org/10.1158/1078-0432.22456172.v1
https://doi.org/10.1158/1078-0432.22456172.v1