Zobrazeno 1 - 10
of 101
pro vyhledávání: '"Katherine M, Aird"'
Autor:
Allison C. Sharrow, Emily Megill, Amanda J. Chen, Afifa Farooqi, Naveen Kumar Tangudu, Apoorva Uboveja, Stacy McGonigal, Nadine Hempel, Nathaniel W. Snyder, Ronald J. Buckanovich, Katherine M. Aird
Publikováno v:
Molecular Metabolism, Vol 89, Iss , Pp 102031- (2024)
Quiescence is a reversible cell cycle exit traditionally thought to be associated with a metabolically inactive state. Recent work in muscle cells indicates that metabolic reprogramming is associated with quiescence. Whether metabolic changes occur i
Externí odkaz:
https://doaj.org/article/fbeda01d725342f2a18d6f4dcb007d47
Autor:
Sarah He, Muhammed Sillah, Aidan R. Cole, Apoorva Uboveja, Katherine M. Aird, Yu-Chih Chen, Yi-Nan Gong
Publikováno v:
Cells, Vol 13, Iss 12, p 1004 (2024)
Background: Identifying cells engaged in fundamental cellular processes, such as proliferation or living/death statuses, is pivotal across numerous research fields. However, prevailing methods relying on molecular biomarkers are constrained by high c
Externí odkaz:
https://doaj.org/article/361366edb0db42e89a5a3a855c51684d
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-3 (2022)
In this Comment, Naveen Tangudu and Katherine Aird discuss recent findings showing that 53BP1 regulates heterochromatin through liquid-liquid phase separation.
Externí odkaz:
https://doaj.org/article/cbdae9241866414ebcb28bf43e3e47be
Autor:
Bo Zhao, Pingyu Liu, Takeshi Fukumoto, Timothy Nacarelli, Nail Fatkhutdinov, Shuai Wu, Jianhuang Lin, Katherine M. Aird, Hsin-Yao Tang, Qin Liu, David W. Speicher, Rugang Zhang
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Here, the authors show that the topoisomerase 1-DNA covalent cleavage complex plays a critical role in mediating cytoplasmic chromatin fragments recognition by cyclic GMP-AMP synthase during senescence. The proposed axis is crucial to promote the inf
Externí odkaz:
https://doaj.org/article/f687034dd13c48c997ad226023ef1a47
Autor:
Steffi Oesterreich, Katherine M. Aird
Publikováno v:
Cancer Immunology Research. 11:401-404
Senescent cancer cells alter their microenvironment through secretion of pro-inflammatory cytokines and chemokines called the senescence-associated secretory phenotype (SASP) and upregulation of immunoinhibitory proteins such as CD80 and programmed d
Publikováno v:
PLoS ONE, Vol 16, Iss 5, p e0251188 (2021)
DNA polymerases play essential functions in replication fork progression and genome maintenance. DNA lesions and drug-induced replication stress result in up-regulation and re-localization of specialized DNA polymerases η and κ. Although oncogene a
Externí odkaz:
https://doaj.org/article/a9cdf275d3554c9b928c3764329a67ce
Publikováno v:
Heliyon, Vol 6, Iss 9, Pp e05097- (2020)
While therapies targeting deficiencies in the homologous recombination (HR) pathway are emerging as the standard treatment for high grade serous ovarian cancer (HGSOC) patients, this strategy is limited to the ~50% of patients with a deficiency in th
Externí odkaz:
https://doaj.org/article/7a7fa06a1dc4461aa0ed0a40af313203
Autor:
Raquel Buj, Katherine M. Aird
Publikováno v:
Molecular & Cellular Oncology, Vol 6, Iss 6 (2019)
p16INK4A (hereafter called p16) is a faithful cellular ally in the fight against tumorigenesis. Although its canonical pathway through retinoblastoma (RB) is well delineated, RB-independent functions for p16 are beginning to emerge. Here we summarize
Externí odkaz:
https://doaj.org/article/0ffed3b61ae74d3dbb26bcba0e6ae2db
Autor:
Raquel Buj, Chi-Wei Chen, Erika S. Dahl, Kelly E. Leon, Rostislav Kuskovsky, Natella Maglakelidze, Maithili Navaratnarajah, Gao Zhang, Mary T. Doan, Helen Jiang, Michael Zaleski, Lydia Kutzler, Holly Lacko, Yiling Lu, Gordon B. Mills, Raghavendra Gowda, Gavin P. Robertson, Joshua I. Warrick, Meenhard Herlyn, Yuka Imamura, Scot R. Kimball, David J. DeGraff, Nathaniel W. Snyder, Katherine M. Aird
Publikováno v:
Cell Reports, Vol 28, Iss 8, Pp 1971-1980.e8 (2019)
Summary: Reprogrammed metabolism and cell cycle dysregulation are two cancer hallmarks. p16 is a cell cycle inhibitor and tumor suppressor that is upregulated during oncogene-induced senescence (OIS). Loss of p16 allows for uninhibited cell cycle pro
Externí odkaz:
https://doaj.org/article/43188544f0f744368b8635d3e2d2aa3b
Autor:
Beth L. Worley, Yeon Soo Kim, Jennifer Mardini, Rameez Zaman, Kelly E. Leon, Piyushi Gupta Vallur, Asvelt Nduwumwami, Joshua I. Warrick, Patrick F. Timmins, Joshua P. Kesterson, Rébécca Phaëton, Nam Y. Lee, Vonn Walter, Lauren Endres, Karthikeyan Mythreye, Katherine M. Aird, Nadine Hempel
Publikováno v:
Redox Biology, Vol 25, Iss , Pp - (2019)
Ovarian cancer remains the most lethal gynecologic malignancy, and is primarily diagnosed at late stage when considerable metastasis has occurred in the peritoneal cavity. At late stage abdominal cavity ascites accumulation provides a tumor-supportin
Externí odkaz:
https://doaj.org/article/0ee39ed6b42940489efa251bb7ae9eb6