Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Katherine L.B. Borden"'
eIF4E orchestrates mRNA processing, RNA export and translation to modify specific protein production
Publikováno v:
Nucleus, Vol 15, Iss 1 (2024)
The eukaryotic translation initiation factor eIF4E acts as a multifunctional factor that simultaneously influences mRNA processing, export, and translation in many organisms. Its multifactorial effects are derived from its capacity to bind to the met
Externí odkaz:
https://doaj.org/article/cc117cf3379445b7b80b015946b17d39
Autor:
Sarit Assouline, Jadwiga Gasiorek, Julie Bergeron, Caroline Lambert, Biljana Culjkovic-Kraljacic, Eftihia Cocolakis, Chadi Zakaria, David Szlachtycz, Karen Yee, Katherine L.B. Borden
Publikováno v:
Haematologica, Vol 108, Iss 11 (2023)
Drug resistance underpins poor outcomes in many malignancies including refractory and relapsed acute myeloid leukemia (R/R AML). Glucuronidation is a common mechanism of drug inactivation impacting many AML therapies, e.g., cytarabine, decitabine, az
Externí odkaz:
https://doaj.org/article/826412a4b7274b2ba463c6ba484f9565
Publikováno v:
Cell Reports, Vol 27, Iss 5, Pp 1397-1408.e4 (2019)
Summary: The eukaryotic translation initiation factor eIF4E is nuclear and cytoplasmic where it plays roles in export and translation of specific transcripts, respectively. When we were studying its mRNA export activity, we unexpectedly discovered th
Externí odkaz:
https://doaj.org/article/48357669f435479387bb7fc6d5bf602e
Autor:
Biljana Culjkovic-Kraljacic, Aurélie Baguet, Laurent Volpon, Abdellatif Amri, Katherine L.B. Borden
Publikováno v:
Cell Reports, Vol 2, Iss 2, Pp 207-215 (2012)
The eukaryotic translation initiation factor eIF4E is a potent oncogene that promotes the nuclear export and translation of specific transcripts. Here, we have discovered that eIF4E alters the cytoplasmic face of the nuclear pore complex (NPC), which
Externí odkaz:
https://doaj.org/article/ff886545fa334171ac500bbbed49f0e7
Autor:
Katherine L.B. Borden
The eukaryotic translation initiation factor eIF4E is elevated in many human cancers. Tissue-specific targeting of eIF4E activity in ovarian cancer cells is achieved in cell culture and in mice by fusing a peptide corresponding to the eIF4E inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02008b69d38de2bdd14b8bfd8909edb3
https://doi.org/10.1158/1078-0432.c.6517912
https://doi.org/10.1158/1078-0432.c.6517912
Autor:
Katherine L.B. Borden
Related Article from Tissue Targeting in Cancer: eIF4E's Tale
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ca768c13d952205e88b29c9c97bb661
https://doi.org/10.1158/1078-0432.22440610.v1
https://doi.org/10.1158/1078-0432.22440610.v1
Autor:
Frank J. Rauscher, Katherine L.B. Borden, Shoukat Dedhar, Qihong Huang, Emmanuel Skordalakes, David W. Speicher, Alexandra S. Carolin, Christopher S. Paterno, Bruce Malkowicz, William Fredericks, Andrew J. Caton, Meenhard Herlyn, Torben Orntoft, Electron Kebebew, Mei He, Zhaoyuan Hou, Jayashree Karar, Paul C. McDonald, Jeremy W. Prokop, Michael J. Osborne, Mehdi Talebzadeh-Farrooji, Hongzhuang Peng
Total mRNA was extracted from cancer cell lines using RNeasy Mini Kit (Qiagen).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ade46a990104f62bb8b08043921e726
https://doi.org/10.1158/0008-5472.22401225
https://doi.org/10.1158/0008-5472.22401225
Autor:
Frank J. Rauscher, Katherine L.B. Borden, Shoukat Dedhar, Qihong Huang, Emmanuel Skordalakes, David W. Speicher, Alexandra S. Carolin, Christopher S. Paterno, Bruce Malkowicz, William Fredericks, Andrew J. Caton, Meenhard Herlyn, Torben Orntoft, Electron Kebebew, Mei He, Zhaoyuan Hou, Jayashree Karar, Paul C. McDonald, Jeremy W. Prokop, Michael J. Osborne, Mehdi Talebzadeh-Farrooji, Hongzhuang Peng
Data collection and refinement statistics for the LIMD2 protein.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ec879013ecfb6420d949626ab145f75
https://doi.org/10.1158/0008-5472.22401207
https://doi.org/10.1158/0008-5472.22401207
Autor:
Frank J. Rauscher, Katherine L.B. Borden, Shoukat Dedhar, Qihong Huang, Emmanuel Skordalakes, David W. Speicher, Alexandra S. Carolin, Christopher S. Paterno, Bruce Malkowicz, William Fredericks, Andrew J. Caton, Meenhard Herlyn, Torben Orntoft, Electron Kebebew, Mei He, Zhaoyuan Hou, Jayashree Karar, Paul C. McDonald, Jeremy W. Prokop, Michael J. Osborne, Mehdi Talebzadeh-Farrooji, Hongzhuang Peng
Proteins that communicate signals from the cytoskeleton to the nucleus are prime targets for effectors of metastasis as they often transduce signals regulating adhesion, motility, and invasiveness. LIM domain proteins shuttle between the cytoplasm an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d208935d2e354ddd11a19006ba308789
https://doi.org/10.1158/0008-5472.c.6505785
https://doi.org/10.1158/0008-5472.c.6505785
Autor:
Frank J. Rauscher, Katherine L.B. Borden, Shoukat Dedhar, Qihong Huang, Emmanuel Skordalakes, David W. Speicher, Alexandra S. Carolin, Christopher S. Paterno, Bruce Malkowicz, William Fredericks, Andrew J. Caton, Meenhard Herlyn, Torben Orntoft, Electron Kebebew, Mei He, Zhaoyuan Hou, Jayashree Karar, Paul C. McDonald, Jeremy W. Prokop, Michael J. Osborne, Mehdi Talebzadeh-Farrooji, Hongzhuang Peng
Legend for Supplementary Figures S1-S6. Also includes Supplementary References.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::226fe022c5c5539b0c3bcf371a82907a
https://doi.org/10.1158/0008-5472.22401231.v1
https://doi.org/10.1158/0008-5472.22401231.v1