Cell surface-tethered IL-12 repolarizes the tumor immune microenvironment to enhance the efficacy of adoptive T cell therapy

Autor: Douglas S. Jones, Jonathan D. Nardozzi, Katharine L. Sackton, Gulzar Ahmad, Esben Christensen, Lars Ringgaard, De-Kuan Chang, Ditte E. Jaehger, Jacob V. Konakondla, Martin Wiinberg, Katherine L. Stokes, Alvin Pratama, Karsten Sauer, Thomas L. Andresen

Publikováno v: Jones, D S, Nardozzi, J D, Sackton, K L, Ahmad, G, Christensen, E, Ringgaard, L, Chang, D-K, Jaehger, D E, Konakondla, J V, Wiinberg, M, Stokes, K L, Pratama, A, Sauer, K & Andresen, T L 2022, ' Cell surface-tethered IL-12 repolarizes the tumor immune microenvironment to enhance the efficacy of adoptive T cell therapy ', Science Advances, vol. 8, no. 17, eabi8075 . https://doi.org/10.1126/sciadv.abi8075

Immune-activating cytokines such as interleukin-12 (IL-12) hold strong potential for cancer immunotherapy but have been limited by high systemic toxicities. We describe here an approach to safely harness cytokine biology for adoptive cell therapy thr

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https://pubmed.ncbi.nlm.nih.gov/35476449