Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Katherine L. Seley-Radtke"'
Comparison of the Old and New - Novel Mechanisms of Action for Anti-coronavirus Nucleoside Analogues
Publikováno v:
CHIMIA, Vol 76, Iss 5 (2022)
Over the past two and a half years the world has seen a desperate scramble to find a treatment for SARS-CoV-2 and COVID. In that regard, nucleosides have long served as the cornerstone to antiviral treatments due to their resemblance to the naturally
Externí odkaz:
https://doaj.org/article/148b7b3fe0024d9e83a4ea1e0e08b56d
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 14, Iss 1, Pp 772-785 (2018)
C-nucleosides have intrigued biologists and medicinal chemists since their discovery in 1950's. In that regard, C-nucleosides and their synthetic analogues have resulted in promising leads in drug design. Concurrently, advances in chemical syntheses
Externí odkaz:
https://doaj.org/article/90876dcca3ad4d8b9c4621e8d69161a4
Autor:
Sarah C. Zimmermann, Elizaveta O'Neill, Godwin U. Ebiloma, Lynsey J. M. Wallace, Harry P. De Koning, Katherine L. Seley-Radtke
Publikováno v:
Molecules, Vol 19, Iss 12, Pp 21200-21214 (2014)
In an effort to study the effects of flexibility on enzyme recognition and activity, we have developed several different series of flexible nucleoside analogues in which the purine base is split into its respective imidazole and pyrimidine components
Externí odkaz:
https://doaj.org/article/708210525b044d67885064643ab4c7a3
Autor:
Anastasia L. Khandazhinskaya, Elena S. Matyugina, Pavel N. Solyev, Maggie Wilkinson, Karen W. Buckheit, Robert W. Buckheit, Larisa N. Chernousova, Tatiana G. Smirnova, Sofya N. Andreevskaya, Khalid J. Alzahrani, Manal J. Natto, Sergey N. Kochetkov, Harry P. de Koning, Katherine L. Seley-Radtke
Publikováno v:
Molecules, Vol 24, Iss 19, p 3433 (2019)
Carbocyclic nucleosides have long played a role in antiviral, antiparasitic, and antibacterial therapies. Recent results from our laboratories from two structurally related scaffolds have shown promising activity against both Mycobacterium tuberculos
Externí odkaz:
https://doaj.org/article/a637c58484344774bb35089123f966d7
Autor:
Mary K. Yates, Payel Chatterjee, Mike Flint, Yafet Arefeayne, Damjan Makuc, Janez Plavec, Christina F. Spiropoulou, Katherine L. Seley-Radtke
Publikováno v:
Molecules, Vol 24, Iss 17, p 3184 (2019)
Due to their ability to inhibit viral DNA or RNA replication, nucleoside analogues have been used for decades as potent antiviral therapeutics. However, one of the major limitations of nucleoside analogues is the development of antiviral resistance.
Externí odkaz:
https://doaj.org/article/78c75a465cd04518938d23aaa32706c9
Autor:
Brian M. Cawrse, Nia’mani M. Robinson, Nina C. Lee, Gerald M. Wilson, Katherine L. Seley-Radtke
Publikováno v:
Molecules, Vol 24, Iss 14, p 2656 (2019)
Pyrrolo[3,2-d]pyrimidines have been studied for many years as potential lead compounds for the development of antiproliferative agents. Much of the focus has been on modifications to the pyrimidine ring, with enzymatic recognition often modulated by
Externí odkaz:
https://doaj.org/article/82bede22062a461bb729320e8107a876
Autor:
Anastasia L. Khandazhinskaya, Liudmila A. Alexandrova, Elena S. Matyugina, Pavel N. Solyev, Olga V. Efremenkova, Karen W. Buckheit, Maggie Wilkinson, Robert W. Buckheit, Larisa N. Chernousova, Tatiana G. Smirnova, Sofya N. Andreevskaya, Olga G. Leonova, Vladimir I. Popenko, Sergey N. Kochetkov, Katherine L. Seley-Radtke
Publikováno v:
Molecules, Vol 23, Iss 12, p 3069 (2018)
A series of novel 5′-norcarbocyclic derivatives of 5-alkoxymethyl or 5-alkyltriazolyl-methyl uracil were synthesized and the activity of the compounds evaluated against both Gram-positive and Gram-negative bacteria. The growth of Mycobacterium smeg
Externí odkaz:
https://doaj.org/article/df8f90d82864430ebc867f93b84c24a6
Autor:
Jessica R. Spengler, Stephen R. Welch, Jerome Deval, Brian G. Gentry, Andrea Brancale, Kara Carter, Jennifer Moffat, Chris Meier, Katherine L. Seley-Radtke, Luis M. Schang
Publikováno v:
Antiviral Research. 211:105521
The 35th International Conference on Antiviral Research (ICAR), sponsored by the International Society for Antiviral Research (ISAR), was held in Seattle, Washington, USA, on March 21-25, 2022 and concurrently through an interactive remote meeting pl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5d89a954db9f8709dd5b03ffc549f50
https://doi.org/10.1016/j.antiviral.2022.105521
https://doi.org/10.1016/j.antiviral.2022.105521
Publikováno v:
Handbook of Chemical Biology of Nucleic Acids ISBN: 9789811613135
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57bf4f35d45b0c47807cd4ceb5bc56ee
https://doi.org/10.1007/978-981-16-1313-5_67-1
https://doi.org/10.1007/978-981-16-1313-5_67-1
Autor:
Andrea Brancale, Kara Carter, Leen Delang, Jerome Deval, David Durantel, Brian G Gentry, Robert Jordan, Justin G. Julander, Michael K. Lo, Maria-Jesús Pérez-Pérez, Luis M. Schang, Katherine L. Seley-Radtke, Pei-Yong Shi, Subhash G. Vasudevan, Richard J. Whitley, Jessica R. Spengler
Publikováno v:
Antiviral Chemistry and Chemotherapy
Antiviral Chemistry and Chemotherapy, 2022, 30, pp.204020662211308. ⟨10.1177/20402066221130853⟩
Antiviral Chemistry and Chemotherapy, 2022, 30, pp.204020662211308. ⟨10.1177/20402066221130853⟩
As a result of the multiple gathering and travels restrictions during the SARS-CoV-2 pandemic, the annual meeting of the International Society for Antiviral Research (ISAR), the International Conference on Antiviral Research (ICAR), could not be held
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::492d63212b950514e1484b537aeaa950
https://lirias.kuleuven.be/handle/20.500.12942/705930
https://lirias.kuleuven.be/handle/20.500.12942/705930