Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Katherine L. Schutt"'
Autor:
Katherine L. Schutt, Katelyn A. Queen, Kira Fisher, Olivia Budington, Weifeng Mao, Wei Liu, Xiaohui Gu, Yisong Xiao, Fred Aswad, James Joseph, Jason Stumpff
Publikováno v:
Frontiers in Molecular Biosciences, Vol 11 (2024)
Background: The mitotic kinesin, KIF18A, is required for proliferation of cancer cells that exhibit chromosome instability (CIN), implicating it as a promising target for treatment of a subset of aggressive tumor types. Determining regions of the KIF
Externí odkaz:
https://doaj.org/article/cc433fd5932f40ad91df8b3c7b187486
Autor:
Jason Stumpff, Lauren Jepsen, Katherine L. Schutt, April L. Solon, Sarah E. Haynes, David Sept, Michael A. Cianfrocco, Alexey I. Nesvizhskii, Ryoma Ohi, Zhenyu Tan
Publikováno v:
Science Advances
Description
Kinesin-binding protein inhibits kinesin activity through structural alterations of the kinesin motor domain.
Kinesins are regulated in space and time to ensure activation only in the presence of cargo. Kinesin-binding protein (
Kinesin-binding protein inhibits kinesin activity through structural alterations of the kinesin motor domain.
Kinesins are regulated in space and time to ensure activation only in the presence of cargo. Kinesin-binding protein (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77be392396066c958044d0adeb1b7385
http://europepmc.org/articles/PMC8604404
http://europepmc.org/articles/PMC8604404
Autor:
Ryoma Ohi, David Sept, Jason Stumpff, Zhenyu Tan, Michael A. Cianfrocco, April L. Solon, Katherine L. Schutt, Alexey I. Nesvizhskii, Lauren Jepsen, Sarah E. Haynes
Kinesins are tightly regulated in space and time to control their activation in the absence of cargo-binding. Kinesin-binding protein (KIFBP) was recently discovered to bind the catalytic motor heads of 8 of the 45 known kinesin superfamily members a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b44d0d56d7346bd89a4bba595aec0b3c
https://doi.org/10.1101/2021.06.02.446814
https://doi.org/10.1101/2021.06.02.446814
Autor:
James B. Moseley, Katherine L. Schutt
Publikováno v:
Cytoskeleton (Hoboken)
A hallmark of cell division in eukaryotic cells is the formation and elongation of a microtubule-based mitotic spindle. Proper positioning of the spindle is critical to ensure equal segregation of the genetic material to the resulting daughter cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d54fa2a15b47cf8bbbc8504c6d2f4bb
https://europepmc.org/articles/PMC8195570/
https://europepmc.org/articles/PMC8195570/
Autor:
James B. Moseley, Katherine L. Schutt
Publikováno v:
Molecular Biology of the Cell
Transient activation of the cellular energy sensor AMPK during osmotic stress requires its energy-sensing subunit. Cellular ATP levels decrease during osmotic stress, which triggers energy stress, which in turn requires dynamic activation of AMPK.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7eb51ec27b4f1fb3319b70bd66252188
https://doi.org/10.1091/mbc.e17-04-0235
https://doi.org/10.1091/mbc.e17-04-0235
Autor:
James B. Moseley, Katherine L. Schutt
Publikováno v:
Molecular Biology of the Cell
Animal and fungal cells divide through the assembly, anchoring, and constriction of a contractile actomyosin ring (CAR) during cytokinesis. The timing and position of the CAR must be tightly controlled to prevent defects in cell division, but many of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd08f29415be206aae6ce9851092c517
https://pubmed.ncbi.nlm.nih.gov/31553675
https://pubmed.ncbi.nlm.nih.gov/31553675
Publikováno v:
Molecular and cellular biology. 37(10)
AMPK-related protein kinases (ARKs) coordinate cell growth, proliferation, and migration with environmental status. It is unclear how specific ARKs are activated at specific times. In the fission yeast Schizosaccharomyces pombe, the CaMKK-like protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31722d511a0e307e6a0a5b49afa17a31
https://pubmed.ncbi.nlm.nih.gov/28223368
https://pubmed.ncbi.nlm.nih.gov/28223368
Publikováno v:
Bioanalysis. 4:2525-2541
The identification and quantification of important biomarkers is a critical first step in the elucidation of biological systems. Biomarkers take many forms as cellular responses to stimuli and can be manifested during transcription, translation, and/
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe5893cf32e095118e9ee49c2dc1450b
https://doi.org/10.4155/bio.12.208
https://doi.org/10.4155/bio.12.208