Výsledky vyhledávání - "Katherine L. Pratt"

Growth Hormone (GH) Insensitivity and Insulin-Like Growth Factor-I Deficiency in Inuit Subjects and an Ecuadorian Cohort: Functional Studies of Two Codon 180 GH Receptor Gene Mutations

Autor: Peng Fang, Brian M. Little, Jaime Guevara-Aguirre, Vivian Hwa, Rose Girgis, Ron G. Rosenfeld, Katherine L. Pratt

Publikováno v: The Journal of Clinical Endocrinology & Metabolism. 93:1030-1037

Context: Among more than 250 cases of GH insensitivity syndrome (GHIS) reported to date, the largest cohort was identified in southern Ecuador. In the Ecuadorian GHIS cohort, a sense mutation (GAA > GAG) at codon E180 of GH receptor [GHR (E180sp)] re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bbcf5ad3a2bfd99189966fdb4b95bb5
https://doi.org/10.1210/jc.2007-2022

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Primary Growth Hormone (GH) Insensitivity and Insulin-Like Growth Factor Deficiency Caused by Novel Compound Heterozygous Mutations of the GH Receptor Gene: Genetic and Functional Studies of Simple and Compound Heterozygous States

Autor: Vivian Hwa, Peng Fang, Herwig Frisch, Brian M. Little, Serge Amselem, Ron G. Rosenfeld, Gabriele Haeusler, Stefan Riedl, Katherine L. Pratt

Publikováno v: The Journal of Clinical Endocrinology & Metabolism. 92:2223-2231

Primary GH insensitivity (GHI) or Laron syndrome, caused by mutations of the GH receptor (GHR) gene, has a clinical phenotype of postnatal growth failure associated with normal elevated serum concentrations of GH and low serum levels of IGF-I.We inve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d076a53587deaf94176143bbf0cbfb96
https://doi.org/10.1210/jc.2006-2624

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Insulin Resistance Is Associated With Increased Serum Concentration of IGF-Binding Protein–Related Protein 1 (IGFBP-rP1/MAC25)

Autor: Ron G. Rosenfeld, José Manuel Fernández-Real, Abel López-Bermejo, Wifredo Ricart, Maria García-Gil, Javad Khosravi, Roser Casamitjana, Katherine L. Pratt, Vivian Hwa

Publikováno v: Diabetes. 55:2333-2339

IGF-binding protein (IGFBP)-related protein 1 (IGFBP-rP1) has been shown to bind both IGFs and insulin, albeit with low affinity, and to inhibit insulin signaling. We hypothesized that IGFBP-rP1 is associated with insulin resistance and components of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e811d52be1d36b16a7096705dcd754b6
https://doi.org/10.2337/db05-1627

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Severe Growth Hormone Insensitivity Resulting from Total Absence of Signal Transducer and Activator of Transcription 5b

Autor: Pelin Adiyaman, Brian M. Little, Eric M. Kofoed, Merih Berberoğlu, Vivian Hwa, Gönül Öcal, Ron G. Rosenfeld, Katherine L. Pratt

Publikováno v: The Journal of Clinical Endocrinology & Metabolism. 90:4260-4266

Context: The central clinical feature of GH insensitivity (GHI) is severe growth failure associated with elevated serum concentrations of GH and abnormally low serum levels of IGF-I. GHI can be the result of an abnormality in the GH receptor or aberr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72e4d15f62dc24558937cfa5593dea3e
https://doi.org/10.1210/jc.2005-0515

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Circulating Ghrelin Levels Are Suppressed by Meals and Octreotide Therapy in Children with Prader-Willi Syndrome

Autor: Katherine L. Pratt, Stephen H. LaFranchi, Jonathan Q. Purnell, Andrea M. Haqq, Ron G. Rosenfeld, David E. Cummings, Diane D. Stadler, David S. Weigle, R. Scott Frayo

Publikováno v: The Journal of Clinical Endocrinology & Metabolism. 88:3573-3576

Prader-Willi syndrome (PWS) is characterized by severe obesity, hyperphagia, hypogonadism, and GH deficiency. Unlike individuals with common obesity, who have low fasting-plasma ghrelin concentrations, those with PWS have high fasting-ghrelin concent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f4ffa6ac1e9c1183998e13cd6f94925
https://doi.org/10.1210/jc.2003-030205

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Serum Ghrelin Levels Are Inversely Correlated with Body Mass Index, Age, and Insulin Concentrations in Normal Children and Are Markedly Increased in Prader-Willi Syndrome

Autor: Stephen H. LaFranchi, Andrea M. Haqq, Ron G. Rosenfeld, Diane D. Stadler, Jonathan Q. Purnell, I. Sadaf Farooqi, Katherine L. Pratt, Stephen O'Rahilly

Publikováno v: The Journal of Clinical Endocrinology & Metabolism. 88:174-178

Ghrelin, an endogenous ligand of the GH secretagogue receptor, stimulates appetite and causes obesity in animal models and in humans when given in pharmacologic doses. Prader-Willi Syndrome (PWS) is a genetic obesity syndrome characterized by GH defi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8959f7984d9acde94af620ce6f15a309
https://doi.org/10.1210/jc.2002-021052

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Usefulness of Different Biochemical Markers of the Insulin-Like Growth Factor (IGF) Family in Diagnosing Growth Hormone Excess and Deficiency in Adults1

Autor: Ron G. Rosenfeld, Annamaria Colao, Carolina Di Somma, Gaetano Lombardi, Anastasia Diamandis, Katherine L. Pratt, Javad Khosravi, Paolo Marzullo

Publikováno v: The Journal of Clinical Endocrinology & Metabolism. 86:3001-3008

The diagnostic approach to acromegaly and GH deficiency frequently includes measurement of several components of the insulinlike growth factor (IGF) system. IGF-I levels are reported to be good predictors of active and cured acromegaly, but are commo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::11e99227062182b7c60f54c64da67f53
https://doi.org/10.1210/jcem.86.7.7628

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Regulation of somatic growth by the p160 coactivator p/CIP

Autor: Wei Wu, David W. Rose, Anatoli S. Gleiberman, Forrest Liu, Christopher K. Glass, Anna Krones, Ron G. Rosenfeld, Daniel P. Szeto, Michael G. Rosenfeld, Ola Hermanson, Katherine L. Pratt, Zhiyong Wang, Thomas Herman

Publikováno v: Proceedings of the National Academy of Sciences. 97:13549-13554

A family of p160 coactivators was initially identified based on ligand-dependent interactions with nuclear receptors and thought to function, in part, by recruiting CREB-binding protein/p300 to several classes of transcription factors. One of the p16

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2db12ed73486f04401b1b918cf8f2ec7
https://doi.org/10.1073/pnas.260463097

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Extreme elevation of serum growth hormone-binding protein concentrations resulting from a novel heterozygous splice site mutation of the growth hormone receptor gene

Autor: Brian M. Little, Katherine L. Pratt, Ron G. Rosenfeld, Daisy Chin, Vivian Hwa, Anna M. Aalbers, Stuart J. Frank

Publikováno v: Hormone research. 71(5)

Background/Aims: Circulating growth hormone-binding protein (GHBP), in humans, is the proteolytic product of the growth hormone receptor (GHR). We investigated a prepubertal male subject who was of short stature, but who had a markedly elevated serum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cf15939ff6c70376c2fd5c4e4debfe8
https://pubmed.ncbi.nlm.nih.gov/19339792

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Insulin-like growth factor binding protein-related protein 1 (IGFBP-rP1/MAC25) is linked to endothelial-dependent vasodilation in high-ferritin type 2 diabetes

Autor: Vivian Hwa, Abel López-Bermejo, Katherine L. Pratt, Ron G. Rosenfeld, Antoni Castro, José Manuel Fernández-Real, Wifredo Ricart, Roser Casamitjana, Javad Khosravi

Publikováno v: Diabetes care. 30(6)

Type 2 diabetes is characterized by variable degrees of vascular dysfunction (1,2). We have recently reported improved vasomotor responses in high-ferritin type 2 diabetic patients following bloodletting (3), an intervention that is believed to reduc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29f1c45ededa3b1412d6f3514b11cd2f
https://pubmed.ncbi.nlm.nih.gov/17351286

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