Výsledky vyhledávání - "Katherine L. Olin"

Proteoglycans Synthesized by Arterial Smooth Muscle Cells in the Presence of Transforming Growth Factor-β1 Exhibit Increased Binding to LDLs

Autor: Alan Chait, Lisa R. Tannock, Peter J. Little, Katherine L. Olin, Thomas N. Wight

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 22:55-60

The “response-to-retention” hypothesis of atherogenesis states that atherogenic lipoproteins, such as low density lipoprotein (LDL), are retained in vessels by proteoglycans and undergo proatherosclerotic modifications. Transforming growth factor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::276bd522f86fad2d27fbfd11eb6c1ec2
https://doi.org/10.1161/hq0102.101100

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Triglyceride-Rich Lipoproteins from Subjects with Type 2 Diabetes Do Not Demonstrate Increased Binding to Biglycan, a Vascular Proteoglycan

Autor: Thomas N. Wight, Lisa R. Tannock, Alan Chait, Katherine L. Olin, P. Hugh R. Barrett

Publikováno v: The Journal of Clinical Endocrinology & Metabolism. 87:35-40

Retention of atherogenic apolipoprotein (apo) B- and E- containing lipoproteins by their interaction with arterial wall proteoglycans is important in atherogenesis. Levels of triglyceride (TG)-rich lipoproteins, which contain both apo B and apo E, ar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af9a450c567c927e4f4c8af5a883ce6b
https://doi.org/10.1210/jcem.87.1.8190

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Plasma Extracellular Superoxide Dismutase Activity in Healthy Pregnant Women Is Not Influenced by Zinc Supplementation

Autor: Kelley E. Johnston, Tsunenobu Tamura, Mary B. DuBard, Carl L. Keen, Katherine L. Olin, Robert L. Goldenberg

Publikováno v: Biological Trace Element Research. 80:107-113

We hypothesized that plasma extracellular superoxide dismutase (EC-SOD) activity reflects the zinc nutriture of healthy pregnant women. Sixty-three women were selected from 580 African-American women who participated in a clinical trial to evaluate t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a611dc3f9c259110d511a920f2e65f0f
https://doi.org/10.1385/bter:80:2:107

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Lipoprotein Lipase Enhances the Binding of Native and Oxidized Low Density Lipoproteins to Versican and Biglycan Synthesized by Cultured Arterial Smooth Muscle Cells

Autor: Thomas N. Wight, Susan Potter-Perigo, Katherine L. Olin, P. Hugh R. Barrett, Alan Chait

Publikováno v: Journal of Biological Chemistry. 274:34629-34636

Retention of low density lipoproteins (LDL) by vascular proteoglycans and their subsequent oxidation are important in atherogenesis. Lipoprotein lipase (LPL) can bind LDL and proteoglycans, although the effect of different proteoglycans to influence

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f78d6cde2e0f9238c3d9424a9962b56
https://doi.org/10.1074/jbc.274.49.34629

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Comparison of Apolipoprotein and Proteoglycan Deposits in Human Coronary Atherosclerotic Plaques

Autor: Alan Chait, Marina S. Ferguson, Kevin D. O'Brien, Winnie S. Chiu, Kelly L. Hudkins, Katherine L. Olin, Thomas N. Wight, Charles E. Alpers

Publikováno v: Circulation. 98:519-527

Background —Because the content of specific proteoglycans and apolipoproteins is increased in atherosclerotic plaques and in vitro studies have suggested a role for proteoglycans in mediating plaque apolipoprotein (apo) retention, immunohistochemis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ce3a5e2b8f92dae8c891924bf2087db
https://doi.org/10.1161/01.cir.98.6.519

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Identification of the principal proteoglycan-binding site in LDL. A single-point mutation in apo-B100 severely affects proteoglycan interaction without affecting LDL receptor binding

Autor: T L Innerarity, Alan Chait, I Lee, Katherine L. Olin, J Borén, Thomas N. Wight

Publikováno v: Journal of Clinical Investigation. 101:2658-2664

The subendothelial retention of LDLs through their interaction with proteoglycans has been proposed to be a key process in the pathogenesis of atherosclerosis. In vitro studies have identified eight clusters of basic amino acids in delipidated apo-B1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4a2efa89255b280bf80e87cbe449cf0
https://doi.org/10.1172/jci2265

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Human Monocyte-derived Macrophages Secrete Two Forms of Proteoglycan-Macrophage Colony-stimulating Factor That Differ in Their Ability to Bind Low Density Lipoproteins

Autor: Christina Tsoi, Katherine L. Olin, Mary Y. Chang, Thomas N. Wight, Alan Chait

Publikováno v: Journal of Biological Chemistry. 273:15985-15992

This study evaluated whether human monocyte-derived macrophages synthesize specific types of proteoglycans with lipoprotein-binding capability that could contribute to lipid retention in the arterial wall. After labeling with either [35S]SO4 or [35S]

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b90e5d6494601025da137df763e7db1
https://doi.org/10.1074/jbc.273.26.15985

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Oxidant Defense Systems in Testes from Zinc-Deficient Rats

Autor: Katherine L. Olin, Patricia L. Oteiza, Carl L. Keen, Cesar G. Fraga

Publikováno v: Experimental Biology and Medicine. 213:85-91

Previous studies have demonstrated that zinc deficiency can be associated with high rates of oxidative damage to testes lipids, proteins, and DNA in male rats. In the present work, different aspects of the oxidant defense system (enzymes and lipid-so

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04521564764a30ced46ad298404e91b4
https://doi.org/10.3181/00379727-213-44040

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Extracellular superoxide dismutase activity is affected by dietary zinc intake in nonhuman primate and rodent models

Autor: M E Gershwin, Katherine L. Olin, Carl L. Keen, Mari S. Golub, Bo Lönnerdal, Andrew G Hendrickx

Publikováno v: The American Journal of Clinical Nutrition. 61:1263-1267

Assessment of zinc nutriture is often compromised by the lack of reliable biomarkers. In the present study the effect of dietary zinc deprivation on plasma extracellular superoxide dismutase (EC SOD) activity was investigated in rat and rhesus macaqu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbe889190dc961bb04bd1b83fa9d2b16
https://doi.org/10.1093/ajcn/61.6.1263

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