Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Katherine L. Mitchell"'
Autor:
Amit K Patel, Xin Duan, Mai T. Vu, Cynthia Berlinicke, Cassidy D. Lee, Karl J. Wahlin, Vance Lemmon, Santiago Vilar, Vinod Jaskula-Ranga, Hassan Al-Ali, Yang Hu, Tianlun Lu, Anna La Torre, Risa M. Broyer, Derek S. Welsbie, Katherine L. Mitchell, Donald J. Zack, Mikaela Louie, John L. Bixby, Robert N. Weinreb
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Axonal injury plays a major role in many neurodegenerative diseases. The dual leucine zipper kinase (DLK) signaling pathway is a key regulator of axonal injury-induced neuronal cell death; however, DLK also has an important role in promo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0acc40136a725b6091a16b6c1e9ee826
https://doi.org/10.1073/pnas.2004683117
https://doi.org/10.1073/pnas.2004683117
Autor:
Harry A Quigley, Ian F Pitha, Derek S Welsbie, Cathy Nguyen, Matthew R Steinhart, Thao D Nguyen, Mary Ellen Pease, Ericka N Oglesby, Cynthia A Berlinicke, Katherine L Mitchell, Jessica Kim, Joan J Jefferys, Elizabeth C Kimball
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0141137 (2015)
PURPOSE:To determine if oral losartan treatment decreases the retinal ganglion cell (RGC) death caused by experimental intraocular pressure (IOP) elevation in mice. METHODS:We produced IOP increase in CD1 mice and performed unilateral optic nerve cru
Externí odkaz:
https://doaj.org/article/0d0747c61877472a92a3e9b845b4eee6
Autor:
Donald J. Zack, Jie Cheng, Xitiz Chamling, Derek S. Welsbie, Katherine L. Mitchell, Melissa M. Liu, Cynthia A. Berlinicke, Valentin M. Sluch
Publikováno v:
Stem Cells Translational Medicine
Human pluripotent stem cells have the potential to promote biological studies and accelerate drug discovery efforts by making possible direct experimentation on a variety of human cell types of interest. However, stem cell cultures are generally hete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d31acc14205a3b9709eef3a83187025e
https://doi.org/10.1002/sctm.17-0059
https://doi.org/10.1002/sctm.17-0059
Autor:
Katherine L, Mitchell
Publikováno v:
Federal practitioner : for the health care professionals of the VA, DoD, and PHS. 34(7)
Health care providers are in the unique position to promote a healthy postdeployment transition by assisting veterans to recognize nonpathologic transition symptoms, select appropriate coping strategies, and seek further assistance for more complex p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9e878da6c97975a289434cbe17d0d936
https://pubmed.ncbi.nlm.nih.gov/30766286
https://pubmed.ncbi.nlm.nih.gov/30766286
Role of SARM1 and DR6 in retinal ganglion cell axonal and somal degeneration following axonal injury
Autor:
Olivia J. Marola, Peter Shrager, Amit Patel, Donald J. Zack, Derek S. Welsbie, Katherine L. Mitchell, Richard T. Libby, Kimberly A. Fernandes
Optic neuropathies such as glaucoma are characterized by the degeneration of retinal ganglion cells (RGCs) and the irreversible loss of vision. In these diseases, focal axon injury triggers a propagating axon degeneration and, eventually, cell death.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a5946b63525d02ff12d235e00d03322
https://escholarship.org/uc/item/1054d8tr
https://escholarship.org/uc/item/1054d8tr
Autor:
Eugen Buehler, John A. Fuller, Iain D. C. Fraser, Yan Ge, Yukan Duan, Scott E. Martin, Derek S. Welsbie, Katherine L. Mitchell, Byung Jin Kim, Zhiyong Yang, Ze'ev Ronai, Cynthia A. Berlinicke, Valentin M. Sluch, Jessica Kim, Amit K Patel, Eman Hamed, Lei Lei, Xitiz Chamling, Donald J. Zack, Ping Wu Zhang, Vinod Jaskula-Ranga
Publikováno v:
Neuron, vol 94, iss 6
Dual leucine zipper kinase (DLK) has been implicated in cell death signaling secondary to axonal damage in retinal ganglion cells (RGCs) and other neurons. To better understand the pathway through which DLK acts, we developed enhanced functional geno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dea3afd6d3181a7ea420eb91995d49a4
https://escholarship.org/uc/item/08p4026c
https://escholarship.org/uc/item/08p4026c
Autor:
Zhenhua Xu, Junsong Gong, Yanhong Wei, Rajesh K. Thimmulappa, Shyam Biswal, Derek S. Welsbie, Katherine L. Mitchell, Elia J. Duh
Delayed revascularization of ischemic neural tissue is a major impediment to preservation of function in central nervous system (CNS) diseases including stroke and ischemic retinopathies. Therapeutic strategies allowing rapid revascularization are gr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e7a85b495cc9df28f55115f0c814443
https://europepmc.org/articles/PMC4687549/
https://europepmc.org/articles/PMC4687549/
Autor:
Ericka N. Oglesby, Joan J. Jefferys, Mary Ellen Pease, Elizabeth C. Kimball, Thao D. Nguyen, Harry A. Quigley, Jessica Kim, Ian Pitha, Cathy Nguyen, Matthew R. Steinhart, Derek S. Welsbie, Katherine L. Mitchell, Cynthia Berlinicke
Publikováno v:
PLoS ONE
PLoS ONE, Vol 10, Iss 10, p e0141137 (2015)
PLoS ONE, Vol 10, Iss 10, p e0141137 (2015)
Purpose To determine if oral losartan treatment decreases the retinal ganglion cell (RGC) death caused by experimental intraocular pressure (IOP) elevation in mice. Methods We produced IOP increase in CD1 mice and performed unilateral optic nerve cru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8631df14f13345a6904e7ca05b7e0e2a
https://pubmed.ncbi.nlm.nih.gov/26505191
https://pubmed.ncbi.nlm.nih.gov/26505191
Autor:
Elia J. Duh, Hongkwan Cho, Lijuan Wu, Michael B. Sporn, Shuang Wang, Matthew J. Hartsock, Derek S. Welsbie, Katherine L. Mitchell, Junsong Gong, Yanhong Wei, Zhenhua Xu, Rajesh K. Thimmulappa, Shyam Biswal
Publikováno v:
Journal of neurochemistry. 133(2)
Retinal ischemia plays a critical role in multiple vision-threatening diseases and leads to death of retinal neurons, particularly ganglion cells. Oxidative stress plays an important role in this ganglion cell loss. Nrf2 (NF-E2-related factor 2) is a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4c8442e28c54af8f35c327ebafcd0c9
https://pubmed.ncbi.nlm.nih.gov/25683606
https://pubmed.ncbi.nlm.nih.gov/25683606
Autor:
Derek S. Welsbie, Zhiyong Yang, Yan Ge, Katherine L. Mitchell, Xinrong Zhou, Scott E. Martin, Cynthia A. Berlinicke, Laszlo Hackler, John Fuller, Jie Fu, Li-hui Cao, Bing Han, Douglas Auld, Tian Xue, Syu-ichi Hirai, Lucie Germain, Caroline Simard-Bisson, Richard Blouin, Judy V. Nguyen, Chung-ha O. Davis, Raymond A. Enke, Sanford L. Boye, Shannath L. Merbs, Nicholas Marsh-Armstrong, William W. Hauswirth, Aaron DiAntonio, Robert W. Nickells, James Inglese, Justin Hanes, King-Wai Yau, Harry A. Quigley, Donald J. Zack
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 110(10)
Glaucoma, a major cause of blindness worldwide, is a neurodegenerative optic neuropathy in which vision loss is caused by loss of retinal ganglion cells (RGCs). To better define the pathways mediating RGC death and identify targets for the developmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11c386d3648f9ff405c5518158b256e3
https://pubmed.ncbi.nlm.nih.gov/23431148
https://pubmed.ncbi.nlm.nih.gov/23431148