Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Katherine L Jones"'
Autor:
Jonathan D. Worboys, Katherine N. Vowell, Roseanna K. Hare, Ashley R. Ambrose, Margherita Bertuzzi, Michael A. Conner, Florence P. Patel, William H. Zammit, Judit Gali-Moya, Khodor S. Hazime, Katherine L. Jones, Camille Rey, Stipan Jonjic, Tihana Lenac Rovis, Gillian M. Tannahill, Gabriela Dos Santos Cruz De Matos, Jeremy D. Waight, Daniel M. Davis
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract TIGIT is an inhibitory receptor expressed on lymphocytes and can inhibit T cells by preventing CD226 co-stimulation through interactions in cis or through competition of shared ligands. Whether TIGIT directly delivers cell-intrinsic inhibito
Externí odkaz:
https://doaj.org/article/748927d78b7a4a85add810c7f0791c02
Publikováno v:
npj Science of Learning, Vol 7, Iss 1, Pp 1-8 (2022)
Abstract Adult hippocampal neurogenesis in the developmental process of generating and integrating new neurons in the hippocampus during adulthood and is a unique form of structural plasticity with enormous potential to modulate neural circuit functi
Externí odkaz:
https://doaj.org/article/8b4889c68d41406eb2452d582c59a497
Autor:
Philip G. Humphreys, Niall A. Anderson, Paul Bamborough, Andrew Baxter, Chun-wa Chung, Rosa Cookson, Peter D. Craggs, Toryn Dalton, Julie C. L. Fournier, Laurie J. Gordon, Heather F. Gray, Matthew W. Gray, Richard Gregory, David J. Hirst, Craig Jamieson, Katherine L. Jones, Hripsimee Kessedjian, David Lugo, Grant McGonagle, Vipulkumar K. Patel, Christopher Patten, Darren L. Poole, Rab K. Prinjha, Cesar Ramirez-Molina, Inmaculada Rioja, Gail Seal, Kayleigh A. J. Stafford, Rishi R. Shah, Daniel Tape, Natalie H. Theodoulou, Laura Tomlinson, Sabri Ukuser, Ian D. Wall, Natalie Wellaway, Gemma White
Publikováno v:
Journal of Medicinal Chemistry. 65:15174-15207
The bromodomain and extra terminal (BET) family of proteins are an integral part of human epigenome regulation, the dysregulation of which is implicated in multiple oncology and inflammatory diseases. Disrupting the BET family bromodomain acetyl-lysi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::247c403b556d0cdc2a89bb75345904c1
https://doi.org/10.1021/acs.jmedchem.2c01102
https://doi.org/10.1021/acs.jmedchem.2c01102
Autor:
Patricia F Medeiros, Mythily Vimal, Vipulkumar Kantibhai Patel, John Evans, Neil R Carlson, Antonia J. Lewis, Paul Bamborough, Katherine L Jones, Jane E Smith, Michael O'Sullivan, Scott McCleary, Darren J. Mitchell, Heather Barnett, Chun-wa Chung, Gang Yao, Anthony W. J. Cooper, Rab K. Prinjha, Laurie Gordon, Mahnoor Mahmood, Peter D. Craggs, Isobel L Harada, Rino A Bit, Natalie Wellaway, Armelle Le Gall, Robert J. Watson, Tony W Dean, Dominique Amans, Ian D. Wall, Kayleigh A J Stafford, Dave Lugo, Matthew J Lindon, Rishi R Shah, David Jonathan Hirst, Chris Patten, Darren L Poole, Jack A Brown, Philip G Humphreys, Robert P Davis, Christopher Roland Wellaway, Pamela J Thomas
Publikováno v:
Journal of Medicinal Chemistry. 63:714-746
The bromodomain and extraterminal (BET) family of bromodomain-containing proteins are important regulators of the epigenome through their ability to recognize N-acetyl lysine (KAc) post-translational modifications on histone tails. These interactions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdb502737af78aed357d47636c87313d
https://doi.org/10.1021/acs.jmedchem.9b01670
https://doi.org/10.1021/acs.jmedchem.9b01670
Publikováno v:
NPJ science of learning. 7(1)
Adult hippocampal neurogenesis in the developmental process of generating and integrating new neurons in the hippocampus during adulthood and is a unique form of structural plasticity with enormous potential to modulate neural circuit function and be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4afb7228827f8526704f8d22c0910ce1
https://pubmed.ncbi.nlm.nih.gov/35842419
https://pubmed.ncbi.nlm.nih.gov/35842419
Publikováno v:
Geological Society of America Abstracts with Programs.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec61a40cb3b763678530392da1768b43
https://doi.org/10.1130/abs/2020am-353796
https://doi.org/10.1130/abs/2020am-353796
Autor:
Lydia, Barnes, Hollie, Blaber, David T K, Brooks, Lewis, Byers, Daniel, Buckley, Zoe C, Byron, Richard G, Chilvers, Liam, Cochrane, Edward, Cooney, Heather A, Damian, Luke, Francis, Daniel, Fu He, Jack M J, Grace, Harley J, Green, Edmund J P, Hogarth, Leyla, Jusu, C Elizabeth, Killalea, Oliver, King, Joseph, Lambert, Zoe J, Lee, Nuria S, Lima, Christina L, Long, May-Li, Mackinnon, Shusha, Mahdy, Jolyon, Matthews-Wright, Makenzie J, Millward, Matthew F, Meehan, Christopher, Merrett, Lisa, Morrison, Hal R I, Parke, Charlotte, Payne, Lawrence, Payne, Craig, Pike, Alexander, Seal, Aaron J, Senior, Keenan M, Smith, Kamile, Stanelyte, Joe, Stillibrand, Rachel, Szpara, Freya F H, Taday, Antony M, Threadgould, Rohan J, Trainor, Jordan, Waters, Oliver, Williams, Carrie K W, Wong, Katherine, Wood, Nick, Barton, Anna, Gruszka, Zoe, Henley, James E, Rowedder, Rosa, Cookson, Katherine L, Jones, Alan, Nadin, Ian E, Smith, Simon J F, Macdonald, Andrew, Nortcliffe
Publikováno v:
Journal of medicinal chemistry. 62(22)
Phosphoinositide-3-kinase δ (PI3Kδ) is a critical regulator of cell growth and transformation and has been explored as a therapeutic target for a range of diseases. Through the exploration of the thienopyrimidine scaffold, we have identified a liga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7fdc25e5b8f8a8c4bddd4753118b0c5e
https://pubmed.ncbi.nlm.nih.gov/31647659
https://pubmed.ncbi.nlm.nih.gov/31647659
Publikováno v:
Marine pollution bulletin. 152
Seagrasses have global distribution and are highly productive and economically valuable habitats. They are sensitive and vulnerable to a range of human-induced pressures, including ongoing exposure to marine litter, such as microplastic particles (5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f33a071f91a0fc568a726597269fa1d
https://pubmed.ncbi.nlm.nih.gov/31957685
https://pubmed.ncbi.nlm.nih.gov/31957685
Publikováno v:
Geological Society of America Abstracts with Programs.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b3fd87545f1c2634c215d903e9412290
https://doi.org/10.1130/abs/2019am-340758
https://doi.org/10.1130/abs/2019am-340758
Publikováno v:
Cancer. 123:861-868
BACKGROUND American Indian and Alaska Native (AI/AN) breast cancer survivors experience disparities in breast cancer incidence and age-adjusted mortality compared with non-Hispanic white (NHW) breast cancer survivors. In addition, mortality-to-incide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e0ee61e667dc8a1a521d97965d49af3d
https://doi.org/10.1002/cncr.30406
https://doi.org/10.1002/cncr.30406