Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Katherine L Friedman"'
Publikováno v:
PLoS Genetics, Vol 16, Iss 2, p e1008608 (2020)
DNA double-strand breaks (DSBs) are toxic forms of DNA damage that must be repaired to maintain genome integrity. Telomerase can act upon a DSB to create a de novo telomere, a process that interferes with normal repair and creates terminal deletions.
Externí odkaz:
https://doaj.org/article/f7c7607b01844026a0659c2e56e471f4
Autor:
Michael D Schaller, Gary McDowell, André Porter, Dorothy Shippen, Katherine L Friedman, Matthew S Gentry, Tricia R Serio, Wesley I Sundquist
Publikováno v:
eLife, Vol 6 (2017)
Numerous concerns have been raised about the sustainability of the biomedical research enterprise in the United States. Improving the postdoctoral training experience is seen as a priority in addressing these concerns, but even identifying who the po
Externí odkaz:
https://doaj.org/article/4a22288ddf17473281626fa8a17bebaf
Autor:
Boting Ning, Michael D Feldkamp, David Cortez, Walter J Chazin, Katherine L Friedman, Ellen Fanning
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0116093 (2015)
Simian virus 40 (SV40) serves as an important model organism for studying eukaryotic DNA replication. Its helicase, Large T-antigen (Tag), is a multi-functional protein that interacts with multiple host proteins, including the ubiquitous ssDNA bindin
Externí odkaz:
https://doaj.org/article/6eff77af34da4f1a9baccc420dad22dc
Publikováno v:
PLoS Pathogens, Vol 10, Iss 12, p e1004536 (2014)
Simian virus 40 (SV40) and cellular DNA replication rely on host ATM and ATR DNA damage signaling kinases to facilitate DNA repair and elicit cell cycle arrest following DNA damage. During SV40 DNA replication, ATM kinase activity prevents concatemer
Externí odkaz:
https://doaj.org/article/51f96afc49484c9a942a57373d7abd6b
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e55055 (2013)
Telomerase is a multi-subunit enzyme that reverse transcribes telomere repeats onto the ends of linear eukaryotic chromosomes and is therefore critical for genome stability. S. cerevisiae telomerase activity is cell-cycle regulated; telomeres are not
Externí odkaz:
https://doaj.org/article/d9854d1a93e94a93ba73531316c916ec
Autor:
Remington E Hoerr, Alex Eng, Celia Payen, Sara C Di Rienzi, M K Raghuraman, Maitreya J Dunham, Bonita J Brewer, Katherine L Friedman
Publikováno v:
GENETICS. 224
Evolution is driven by the accumulation of competing mutations that influence survival. A broad form of genetic variation is the amplification or deletion of DNA (≥50 bp) referred to as copy number variation (CNV). In humans, CNV may be inconsequen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88f18188ce73e54d05eb860a33ba2ae1
https://doi.org/10.1093/genetics/iyad010
https://doi.org/10.1093/genetics/iyad010
Autor:
Remington E. Hoerr, Alex Eng, Celia Payen, Sara C. Di Rienzi, M. K. Raghuraman, Maitreya J. Dunham, Bonita J. Brewer, Katherine L. Friedman
Evolution is driven by the accumulation of competing mutations that influence survival. A broad form of genetic variation is the amplification or deletion of DNA (≥50 bp) referred to as copy number variation. In humans, copy number variation may be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f01d7894fa01806a081c5bc2420639c
https://doi.org/10.1101/2022.06.12.495855
https://doi.org/10.1101/2022.06.12.495855
Autor:
Thomas P. Clements, Katherine L. Friedman, Heather J. Johnson, Cole J. Meier, Jessica Watkins, Amanda J. Brockman, Cynthia J. Brame
Publikováno v:
CBE life sciences education. 21(2)
Large introductory science courses are a particularly important and challenging target for creating inclusive learning environments. In this study, we examined the impact of incorporating learning assistants (LAs) on the learning environment in an in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13e66b7263a4388d351a847f20a57714
https://pubmed.ncbi.nlm.nih.gov/35412327
https://pubmed.ncbi.nlm.nih.gov/35412327
Publikováno v:
Curr Genet
DNA double-strand break repair allows cells to survive both exogenous and endogenous insults to the genome. In yeast, the recombinases Rad51 and Rad52 are central to multiple forms of homology-dependent repair. Classically, Rad51 and Rad52 are though
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6074541a28492d623c7baedd1246a08c
https://doi.org/10.1007/s00294-020-01081-z
https://doi.org/10.1007/s00294-020-01081-z
Publikováno v:
Popul Res Policy Rev
Does childrearing affect the biological functioning of parents? To address this question, we analyze cross-sectional survey and biomarker data from Vanderbilt University’s Nashville Stress and Health Study, a probability sample of non-Hispanic whit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab34400b32fbf8182a6f2ac15f7e6141
https://pubmed.ncbi.nlm.nih.gov/33716366
https://pubmed.ncbi.nlm.nih.gov/33716366