Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Katherine L Dominic"'
Autor:
Katherine L. Dominic, Alexandra V. Schmidt, Henk Granzier, Kenneth S. Campbell, Julian E. Stelzer
Publikováno v:
Frontiers in Physiology, Vol 15 (2024)
Heart failure with preserved ejection fraction (HFpEF) is a major public health challenge, affecting millions worldwide and placing a significant burden on healthcare systems due to high hospitalization rates and limited treatment options. HFpEF is c
Externí odkaz:
https://doaj.org/article/bc48eeacf92a488ba39f62c1b920bc0f
Autor:
Chang Yoon Doh, Katherine L. Dominic, Caitlin E. Swanberg, Nikhil Bharambe, Belinda B. Willard, Ling Li, Rajesh Ramachandran, Julian E. Stelzer
Publikováno v:
ACS Omega. 7:14189-14202
Cardiac myosin binding protein C (cMyBPC) is a critical multidomain protein that modulates myosin cross bridge behavior and cardiac contractility. cMyBPC is principally regulated by phosphorylation of the residues within the M-domain of its N-terminu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::302b46446482d1c5cef854974eb36c10
https://doi.org/10.1021/acsomega.2c00799
https://doi.org/10.1021/acsomega.2c00799
Autor:
Katherine L. Dominic, Joohee Choi, Joshua B. Holmes, Mandeep Singh, Michael J. Majcher, Julian E. Stelzer
Publikováno v:
Journal of General Physiology. 155
Cardiac myosin binding protein C (cMyBPC) is an 11-domain sarcomeric protein (C0–C10) integral to cardiac muscle regulation. In vitro studies have demonstrated potential functional roles for regions beyond the N-terminus. However, the in vivo contr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cde3eee01aec0655597c0faa0eaee5e7
https://doi.org/10.1085/jgp.202213318
https://doi.org/10.1085/jgp.202213318
Publikováno v:
Biophysical Journal. 122:170a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::355009a8c826681f0b4bf012331d5551
https://doi.org/10.1016/j.bpj.2022.11.1066
https://doi.org/10.1016/j.bpj.2022.11.1066
Autor:
Joshua B Holmes, Nikhil Madugula, Ranganath Mamidi, Katherine L Dominic, Chang Yoon Doh, Julian E. Stelzer
Publikováno v:
The Journal of General Physiology
Mamidi et al. investigate the effect of cardiac myosin-binding protein C (cMyBPC) phosphorylation on the response to omecamtiv mecarbil (OM), a candidate heart failure therapy. They show that OM uncouples myocardial force dynamics from cMyBPC phospho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbdc387da64d03df24567301094ba09c
https://doi.org/10.1085/jgp.202012816
https://doi.org/10.1085/jgp.202012816
Autor:
Chang Yoon Doh, Nikhil Bharambe, Joshua B. Holmes, Katherine L. Dominic, Caitlin E. Swanberg, Ranganath Mamidi, Yinghua Chen, Smarajit Bandyopadhyay, Rajesh Ramachandran, Julian E. Stelzer
Publikováno v:
J Struct Biol
INTRODUCTION: The central C4 and C5 domains (C4C5) of cardiac myosin binding protein C (cMyBPC) contain a flexible interdomain linker and a cardiac-isoform specific loop. However, their importance in the functional regulation of cMyBPC has not been e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8573f30c4e8b6bf32b9a3c209b2a8c6
https://doi.org/10.1016/j.jsb.2022.107856
https://doi.org/10.1016/j.jsb.2022.107856
Autor:
Chang Yoon Doh, Katherine L. Dominic, Caitlin E. Swanberg, Nikhil Bharambe, Ling Li, Belinda Willard, Rajesh Ramachandran, Julian E. Stelzer
Publikováno v:
Biophysical Journal. 121:254a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f133570e3e7f7beb3af39599e7e29db8
https://doi.org/10.1016/j.bpj.2021.11.1455
https://doi.org/10.1016/j.bpj.2021.11.1455
Autor:
Dominic, Katherine L., Schmidt, Alexandra V., Granzier, Henk, Campbell, Kenneth S., Stelzer, Julian E.
Publikováno v:
Frontiers in Physiology; 2024, p1-10, 10p
Publikováno v:
American Journal of Physiology: Heart & Circulatory Physiology; Sep2023, Vol. 325 Issue 3, pH449-H467, 19p
Publikováno v:
Cardiovascular Week; 12/30/2024, p696-696, 1p