Výsledky vyhledávání - "Katherine K. Sanford"

Radiation-induced chromatid breaks and deficient DNA repair in cancer predisposition

Autor: Katherine K. Sanford, Ram Parshad

Publikováno v: Critical Reviews in Oncology/Hematology. 37:87-96

Deficient repair of DNA double-strand breaks, resulting in an abnormally high frequency of chromatid breaks after G(2) exposure of cells to radiation, appears to be associated with cancer predisposition. Unrepaired DNA strand breaks contribute to gen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d51f631a51f306fdf165b7d0b1a32214
https://doi.org/10.1016/s1040-8428(00)00111-6

Zobrazit plný text záznamu

Suppression of X-Ray-Induced Chromatid Breaks in Human Tumor Cells by Introduction of Normal Chromosome 4

Autor: Yi Ning, Ram Parshad, Katherine K. Sanford

Publikováno v: Cancer Genetics and Cytogenetics. 118:72-75

Human tumor cells in culture frequently show an infinite lifespan and are characterized by an abnormally high frequency of chromatid breaks after x-irradiation during G 2 phase of the cell cycle. This abnormally high frequency of persistent chromatid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fc0f8efd67c92bbc5cc5b39559691c7
https://doi.org/10.1016/s0165-4608(99)00177-6

Zobrazit plný text záznamu

Cytogenetic responses to G2 phase X-irradiation of cells from retinoblastoma patients

Autor: Ram Parshad, Robert E. Tarone, Floyd M. Price, William F. Benedict, Katherine K. Sanford

Publikováno v: Cancer Genetics and Cytogenetics. 88:43-48

Fibroblast cell lines from 20 retinoblastoma (RB) patients with the hereditary bilateral form of disease compared with 16 lines from normal donors had a significantly higher chromatid aberration frequency (CAF), and more displaced and nondisplaced br

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8ef114711919872ef35be07abac1739
https://doi.org/10.1016/0165-4608(95)00279-0

Zobrazit plný text záznamu

G2 phase repair of X-ray-induced chromosomal DNA damage in trichothiodystrophy cells

Autor: Ram Parshad, Alan R. Lehmann, Robert E. Tarone, Floyd M. Price, Katherine K. Sanford

Publikováno v: Mutation Research Letters. 346:107-114

The repair of X-ray-induced DNA damage during G2 cell-cycle phase has been examined in lines of skin fibroblasts from three patients with trichothiodystrophy (TTD), one with apparently normal and two with defective nucleotide excision repair (NER). T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd40660ca179c17bde7febfefc70e960
https://doi.org/10.1016/0165-7992(95)90058-6

Zobrazit plný text záznamu

Association of deficient DNA repair during G2 phase with progression from benign to malignant state in a line of human skin keratinocytes transfected with ras oncogene

Autor: Ram Parshad, Robert E. Tarone, Petra Boukamp, Floyd M. Price, Katherine K. Sanford, Johng S. Rhim, Norbert E. Fusenig

Publikováno v: Carcinogenesis. 15:33-37

Human skin keratinocytes after malignant neoplastic transformation by infection with Kirsten murine sarcoma virus (KiMSV) or transfection with pSV2 ras (containing an activated c-Ha-ras oncogene) showed a DNA repair deficiency(ies). The repair defici

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a7964022fd870e88d785eed33ac3e36
https://doi.org/10.1093/carcin/15.1.33

Zobrazit plný text záznamu

X-ray-induced chromatid damage in relation to dna repair and cancer incidence in family members

Autor: Katherine K. Sanford, Robert E. Tarone, Robert D. Knight, Floyd M. Price, Ram Parshad

Publikováno v: International Journal of Cancer. 54:589-593

The cytogenetic response to G2-phase X-irradiation was examined in phytohemagglutinin-stimulated peripheral-blood lymphocytes from 69 individuals, a few of whom were cancer patients. The cancer patients had not received radiation or chemotherapy. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::045b06066f6077e2dbd07d6250657816
https://doi.org/10.1002/ijc.2910540412

Zobrazit plný text záznamu

Complementation of a DNA repair deficiency in six human tumor cell lines by chromosome 11

Autor: Katherine K. Sanford, Mitsuo Oshimura, F. M. Price, Bernard E. Weissman, Eric J. Stanbridge, Ram Parshad, J C Barrett, Hitoshi Satoh

Publikováno v: Human Genetics. 88:524-528

Human tumor cells, after x-irradiation during the G2 phase of the cell cycle, show an abnormally high frequency of persistent chromatid breaks and gaps resulting from deficient DNA repair. Addition of a single human chromosome 11 from normal fibrobla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67dbb11d831a62d43c06d99f98a01667
https://doi.org/10.1007/bf00219338

Zobrazit plný text záznamu

EFFECT OF DNA REPAIR INHIBITORS ON THE IN VITRO TEST FOR ALZHEIMER'S DISEASE

Autor: Ram Parshad, Floyd M. Price, Mark B. Schapiro, Katherine K. Sanford

Publikováno v: Journal of the American Geriatrics Society. 46:1331-1333

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d17aef079f96b4b49c713a5176cdee7f
https://doi.org/10.1111/j.1532-5415.1998.tb04566.x

Zobrazit plný text záznamu

XPD polymorphisms: effects on DNA repair proficiency

Autor: Kathy J. Helzlsouer, Ruth M. Lunn, Douglas A. Bell, David M. Umbach, Katherine K. Sanford, Ram Parshad, Emily L. Harris

Publikováno v: Carcinogenesis. 21(4)

XPD codes for a DNA helicase involved in transcription and nucleotide excision repair. Rare XPD mutations diminish nucleotide excision repair resulting in hypersensitivity to UV light and increased risk of skin cancer. Several polymorphisms in this g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abfee8554b512b452dc6aea55f9248c6
https://pubmed.ncbi.nlm.nih.gov/10753184

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání