Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Katherine Jancsics"'
Autor:
Tatiana Gladysheva, Yibin Xiang, A.C Good, Bradford H. Hirth, T Fremgen, Gary Asmussen, Renato Skerlj, A Jain, Kimberly Bishop, J.D Stepp, Ronnie Wei, Katherine Jancsics, Maria Fitzgerald, Jinyu Liu, H.P Biemann, Markus Metz, Andrew T Papoulis
Publikováno v:
Journal of medicinal chemistry. 55(6)
We have studied the subtleties of fragment docking and binding using data generated in a Pim-1 kinase inhibitor program. Crystallographic and docking data analyses have been undertaken using inhibitor complexes derived from an in-house surface plasmo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c35c78468ba65305e73f208d0e42ebe7
https://pubmed.ncbi.nlm.nih.gov/22339127
https://pubmed.ncbi.nlm.nih.gov/22339127
Autor:
Yibin Xiang, Hans-Peter Biemann, Tatiana Gladysheva, Markus Metz, J. David Stepp, Renato Skerlj, Andrew T Papoulis, Andrew C. Good, Kimberly Bishop, Annuradha Jain, Gary Asmussen, Bradford H. Hirth, Katherine Jancsics, Maria Fitzgerald, Ronnie Wei, Jinyu Liu
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(10)
Novel benzofuran-2-carboxylic acids, exemplified by 29, 38 and 39, have been discovered as potent Pim-1 inhibitors using fragment based screening followed by X-ray structure guided medicinal chemistry optimization. The compounds demonstrate potent in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0f2a70806999950d2d3da86a2785090
https://pubmed.ncbi.nlm.nih.gov/21507633
https://pubmed.ncbi.nlm.nih.gov/21507633
Autor:
David J. Stepp, Trish Fremgen, Ronnie Wei, Hans-Peter N. Bieman, Markus Metz, Maria Fitzgerald, Renato Skerlj, Bradforth H. Hirth, Yibin Xiang, Michael Kothe, Gary Asmussen, Andrew T Papoulis, Jinyu Liu, Katherine Jancsics
Publikováno v:
Cancer Research. 71:2790-2790
Pim-1 is a proto-oncogene which encodes for the serine/threonine kinase of the same name. Recently, Pim-1 has been implicated in multiple human cancers, including prostate cancer, acute myeloid leukemia and other hematopoietic malignancies. Primarily
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1cba0c0a53264004830e8398c7e4309e
https://doi.org/10.1158/1538-7445.am2011-2790
https://doi.org/10.1158/1538-7445.am2011-2790