Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Katherine J. Rowland"'
Autor:
Kenneth Aldape, Valerie A. Wallace, Nicole I. Park, Ahmed El-Sehemy, Katherine J. Rowland, Peter B. Dirks, Lilian Lee, Neno T Pokrajac, Yasin Mamatjan, Hayden J. Selvadurai, Arturo Ortín-Martínez, Nobuhiko Tachibana
Publikováno v:
Journal of Clinical Investigation. 130:3069-3086
Glioblastoma multiforme (GBM) contains a subpopulation of cells, GBM stem cells (GSCs), that maintain the bulk tumor and represent a key therapeutic target. Norrin is a Wnt ligand that binds Frizzled class receptor 4 (FZD4) to activate canonical Wnt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b2662391750bad794a6cb43f049ad04
https://doi.org/10.1172/jci128994
https://doi.org/10.1172/jci128994
Autor:
Michael D. Cusimano, Nishani Rajakulendran, Nicole I. Park, Nizar N. Batada, Clarissa C. Pasiliao, Moloud Ahmadi, Caroline Brandon, Graham MacLeod, Ryan J Ward, Sergey Naumenko, Mark Bernstein, Ian D. Clarke, Lilian Lee, Hayden J. Selvadurai, Milly So, Peter B. Dirks, Katherine J. Rowland, Sonam Dolma, Stephane Angers
Developmental signal transduction pathways act diversely, with context-dependent roles across systems and disease types. Glioblastomas (GBMs), which are the poorest prognosis primary brain cancers, strongly resemble developmental systems, but these g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76763b64c4d7805ddb448fa9d3355138
https://europepmc.org/articles/PMC6499328/
https://europepmc.org/articles/PMC6499328/
Autor:
Hayden J. Selvadurai, Xiaoyang Lan, Michelle Kushida, Sonam Dolma, Lea Harrington, Tzvi Aviv, Xueming Zhu, Peter B. Dirks, Lilian Lee, Heather Whetstone, Katherine J. Rowland, Renee Head, Ian D. Clarke, Mike Tyers, Milly So, Changjiang Xu, Gary D. Bader, Mark Bernstein, John H. Brumell, Veronique Voisin, Nicole I. Park
Publikováno v:
Cancer Cell. 29:859-873
Glioblastomas (GBM) grow in a rich neurochemical milieu, but the impact of neurochemicals on GBM growth is largely unexplored. We interrogated 680 neurochemical compounds in patient-derived GBM neural stem cells (GNS) to determine the effects on prol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a51bb2079e08fbfebcb103c60edd1f3e
https://doi.org/10.1016/j.ccell.2016.05.002
https://doi.org/10.1016/j.ccell.2016.05.002
Autor:
Scott P. Heximer, Steven Gu, Angelo Izzo, P. Kay Lund, Daniel R. Storm, Philip E. Dubé, Chandani Upadhyay, Katherine J. Rowland, Christopher J. Rhodes, Jason Leen, Patricia L. Brubaker
Publikováno v:
Endocrinology. 152:436-446
IGF-I, a known secretory product of intestinal subepithelial myofibroblasts (ISEMFs), is essential for the intestinotropic effects of glucagon-like peptide-2 (GLP-2). Furthermore, GLP-2 increases IGF-I mRNA transcript levels in vitro in heterogeneous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8acdcacaace2ed5716f7650b073a6c2
https://doi.org/10.1210/en.2010-0822
https://doi.org/10.1210/en.2010-0822
Publikováno v:
Cancer Research. 78:1117-1117
Norrin signaling is protumorigenic in GBM progression A-Introduction: Norrin, a secreted factor encoded by the Norrie Disease Protein gene (NDP), is an atypical WNT ligand that specifically binds the FZD4 receptor and activates the canonical WNT sign
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9fbbf1647228b9f36e57a4fd04db9df9
https://doi.org/10.1158/1538-7445.am2018-1117
https://doi.org/10.1158/1538-7445.am2018-1117
Publikováno v:
Endocrinology. 149:291-301
Chronic administration of glucagon-like peptide-2 (GLP-2) induces intestinal growth and crypt cell proliferation through an indirect mechanism requiring IGF-I. However, the intracellular pathways through which IGF-I mediates GLP-2-induced epithelial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da0cc934c072b1bd71ef9c0c52832568
https://doi.org/10.1210/en.2007-0561
https://doi.org/10.1210/en.2007-0561
Autor:
Katherine J. Rowland, Alejandra C. Vivas, Robert S. Kirsner, Jennifer C. Tang, Julia Escandon
Publikováno v:
Wound Repair and Regeneration. 19:526-528
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::20ea7c3655197113fb1ec2154a224385
https://doi.org/10.1111/j.1524-475x.2011.00699.x
https://doi.org/10.1111/j.1524-475x.2011.00699.x
Autor:
Wen Zhao, Charlotte X. Dong, Katherine J. Rowland, Sylvie Robine, Tanja Gonska, Chloe J. Solomon, Patricia L. Brubaker, Martin Holzenberger, Cameron A. Ackerley
Publikováno v:
Endocrinology. 155(2)
Glucagon-like peptide-2 (GLP-2) is an intestinal growth-promoting hormone used to treat short bowel syndrome. GLP-2 promotes intestinal growth through a mechanism that involves both IGF-1 and the intestinal-epithelial IGF-1 receptor (IE-IGF-1R). GLP-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc68aba2c37d52e578157684694935b9
https://pubmed.ncbi.nlm.nih.gov/24265452
https://pubmed.ncbi.nlm.nih.gov/24265452
Autor:
Nicole I. Park, Nizar N. Batada, Stephane Angers, Katherine J. Rowland, Peter B. Dirks, Hayden J. Selvadurai, Nishani Rajakulendran
Publikováno v:
Molecular Cancer Research. 14:B14-B14
Glioblastoma multiforme (GBM) is the most common malignant tumour in the central nervous system with a prevalence of 2-3 cases per 100 000 people. Although the standard treatment of surgery, chemotherapy and radiotherapy improve survival, the median
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8dd048e6ca4c16a4c9864836e593481c
https://doi.org/10.1158/1557-3125.devbiolca15-b14
https://doi.org/10.1158/1557-3125.devbiolca15-b14
Publikováno v:
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. 19(4)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::76dd538d7836f22f5d72f6fcbc065cd7
https://pubmed.ncbi.nlm.nih.gov/21649781
https://pubmed.ncbi.nlm.nih.gov/21649781