Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Katherine J. Kopeikina"'
Autor:
Katherine J Kopeikina, Susanne Wegmann, Rose Pitstick, George A Carlson, Brian J Bacskai, Rebecca A Betensky, Bradley T Hyman, Tara L Spires-Jones
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e80834 (2013)
Neurofibrillary tangles (NFTs) of tau are one of the defining hallmarks of Alzheimer's disease (AD), and are closely associated with neuronal degeneration. Although it has been suggested that calcium dysregulation is important to AD pathogenesis, few
Externí odkaz:
https://doaj.org/article/020431432a1f4c968396a817fd88776f
Autor:
Jonathan G. Hanley, Peter Penzes, Katharine R. Smith, Bryan A. Copits, Katherine J. Kopeikina, Sehyoun Yoon, Jessica M. Fawcett-Patel, Marc P. Forrest, Kelly A. Jones, Alain C. Burette, Richard J. Weinberg, Geoffrey T. Swanson
Publikováno v:
Smith, K R, Jones, K A, Kopeikina, K J, Burette, A C, Copits, B A, Yoon, S, Forrest, M P, Fawcett-Patel, J M, Hanley, J G, Weinberg, R J, Swanson, G T & Penzes, P 2017, ' Cadherin-10 maintains excitatory/inhibitory ratio through interactions with synaptic proteins ', Journal of Neuroscience, vol. 37, no. 46, pp. 11127-11139 . https://doi.org/10.1523/JNEUROSCI.1153-17.2017
Appropriate excitatory/inhibitory (E/I) balance is essential for normal cortical function and is altered in some psychiatric disorders, including autism spectrum disorders (ASDs). Cell-autonomous molecular mechanisms that control the balance of excit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94e8155fe6dd711f2bf6590a49766026
https://doi.org/10.1523/jneurosci.1153-17.2017
https://doi.org/10.1523/jneurosci.1153-17.2017
Autor:
Britta Schürmann, Maria Dolores Martin-de-Saavedra, Anthony Bach, Alain C. Burette, Katherine E. Horan, Sehyoun Yoon, Katherine J. Kopeikina, Jessica M. Fawcett-Patel, Ruoqi Gao, Marc P. Forrest, Marco Martina, Joshua Z. Rappoport, Peter Penzes, Kristoffer Myczek, Crystle J. Kelly, Daniel P. Bermingham, Katharine R. Smith, Richard J. Weinberg
Publikováno v:
Molecular Psychiatry. 25:1905-1905
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2bb9bf7434ddd4a25c456c89d1b140da
https://doi.org/10.1038/s41380-020-00872-7
https://doi.org/10.1038/s41380-020-00872-7
Autor:
Katharine R. Smith, Alain C. Burette, Marco Martina, Daniel P. Bermingham, Marc P. Forrest, Katherine E. Horan, Kristoffer Myczek, Jessica M. Fawcett-Patel, Sehyoun Yoon, Maria Dolores Martin-de-Saavedra, Anthony Bach, Joshua Z. Rappoport, Peter Penzes, Britta Schürmann, Ruoqi Gao, Richard J. Weinberg, Katherine J. Kopeikina, Crystle J. Kelly
Publikováno v:
Molecular psychiatry
Postsynaptic trafficking plays a key role in regulating synapse structure and function. While spiny excitatory synapses can be stable throughout adult life, their morphology and function is impaired in Alzheimer’s disease (AD). However, little is k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6faf28b5720d57ac62a104d522f57fb
https://pubmed.ncbi.nlm.nih.gov/30967682
https://pubmed.ncbi.nlm.nih.gov/30967682
Autor:
Peter Penzes, Katharine R. Smith, Katherine J. Kopeikina, Seok Kyu Kang, Theron A. Russell, Ruoqi Gao, Marc P. Forrest, Robert A. Sweet, Christine L. Remmers, Melanie J. Grubisha
Publikováno v:
Biological psychiatry. 83(6)
Background Large-scale genetic studies have revealed that rare sequence variants, including single nucleotide variants (SNVs), in glutamatergic synaptic genes are enriched in schizophrenia patients. However, the majority are too rare to show any asso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb988cbe64669414832f8847e381f8da
https://pubmed.ncbi.nlm.nih.gov/29429502
https://pubmed.ncbi.nlm.nih.gov/29429502
Autor:
Kristoffer Myczek, Katharine R. Smith, Britta Schürmann, Jelena Radulovic, Ruoqi Gao, Katherine J. Kopeikina, Jessica M. Fawcett-Patel, Peter Penzes, Geoffrey T. Swanson, Katherine Leaderbrand
Publikováno v:
Neuron. 84:399-415
SummaryRecent evidence implicates glutamatergic synapses as key pathogenic sites in psychiatric disorders. Common and rare variants in the ANK3 gene, encoding ankyrin-G, have been associated with bipolar disorder, schizophrenia, and autism. Here we d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0760fb53341b14acc03c744abac9980
https://doi.org/10.1016/j.neuron.2014.10.010
https://doi.org/10.1016/j.neuron.2014.10.010
Autor:
Katherine J. Kopeikina, Brian J. Bacskai, Bradley T. Hyman, Susanne Wegmann, Kishore V. Kuchibhotla, Mark L. Andermann, Nikita Rudinskiy, Tara L. Spires-Jones, Jonathan M. Hawkes
Publikováno v:
Kuchibhotla, K V, Wegmann, S, Kopeikina, K J, Hawkes, J, Rudinskiy, N, Andermann, M L, Spires-Jones, T L, Bacskai, B J & Hyman, B T 2014, ' Neurofibrillary tangle-bearing neurons are functionally integrated in cortical circuits in vivo ', Proceedings of the National Academy of Sciences, vol. 111, no. 1, pp. 510-4 . https://doi.org/10.1073/pnas.1318807111
Alzheimer's disease (AD) is pathologically characterized by the deposition of extracellular amyloid-β plaques and intracellular aggregation of tau protein in neurofibrillary tangles (NFTs) (1, 2). Progression of NFT pathology is closely correlated w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2445ba96f048b1eedb64fe569891b7e6
https://doi.org/10.1073/pnas.1318807111
https://doi.org/10.1073/pnas.1318807111
Autor:
Bradley T. Hyman, Alix de Calignon, Robert M. Koffie, Tara L. Spires-Jones, Katherine J. Kopeikina
Publikováno v:
Spires-Jones, T L, Kopeikina, K J, Koffie, R M, de Calignon, A & Hyman, B T 2011, ' Are tangles as toxic as they look? ', Journal of Molecular Neuroscience, vol. 45, no. 3, pp. 438-44 . https://doi.org/10.1007/s12031-011-9566-7
Neurofibrillary tangles are intracellular accumulations of hyperphosphorylated and misfolded tau protein characteristic of Alzheimer's disease and other tauopathies. Classic cross-sectional studies of Alzheimer patient brains showed associations of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2aed52fb64db492ba7803632c7d0751
https://doi.org/10.1007/s12031-011-9566-7
https://doi.org/10.1007/s12031-011-9566-7
Autor:
Hunter J. Fleming, Katherine J. Kopeikina, Maria Dolores Martin-de-Saavedra, Britta Schürmann, Anthony Bach, Eunjoon Kim, Elior Peles, Seil Jang, Olga Varea, Jessica M. Fawcett-Patel, Peter Penzes
Central glutamatergic synapses and the molecular pathways that control them are emerging as common substrates in the pathogenesis of mental disorders. Genetic variation in the contactin associated protein-like 2 (CNTNAP2) gene, including copy number
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bf25d5487010c05a26ef73db7fb4324
https://europepmc.org/articles/PMC4434727/
https://europepmc.org/articles/PMC4434727/
Publikováno v:
Hormones and Behavior. 48:64-74
Many neural systems are undergoing marked development over adolescence, which may heighten an animal's vulnerability to stressors. One consequence may be altered sensitivity to drugs of abuse. We previously reported that social stressors in adolescen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc8dd411f63d6f90a1308d0c507e4d5e
https://doi.org/10.1016/j.yhbeh.2005.01.008
https://doi.org/10.1016/j.yhbeh.2005.01.008