Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Katherine J. Hamilton"'
Autor:
Tanner B. Jefferson, Tianyuan Wang, Wendy N. Jefferson, Yin Li, Katherine J. Hamilton, Paul A. Wade, Carmen J. Williams, Kenneth S. Korach
Publikováno v:
Epigenetics, Vol 18, Iss 1 (2023)
Clinically, developmental exposure to the endocrine disrupting chemical, diethylstilboestrol (DES), results in long-term male and female infertility. Experimentally, developmental exposure to DES results in abnormal reproductive tract phenotypes in m
Externí odkaz:
https://doaj.org/article/5dcfad8a24244727a47b62f679c43874
Publikováno v:
Molecular Metabolism, Vol 18, Iss , Pp 68-78 (2018)
Objective: Studies using the estrogen receptor alpha (ERα) knock-out (αERKO) mice have demonstrated that ERα plays a crucial role in various estrogen-mediated metabolic regulations. ERα is a ligand dependent transcription regulator and its activi
Externí odkaz:
https://doaj.org/article/d97d3dd597684f168235a56d07574911
Autor:
Genevieve V. Dall, Jessica L. Vieusseux, Kenneth S. Korach, Yukitomo Arao, Sylvia C. Hewitt, Katherine J. Hamilton, Elaine Dzierzak, Wah Chin Boon, Evan R. Simpson, Robert G. Ramsay, Torsten Stein, Joanne S. Morris, Robin L. Anderson, Gail P. Risbridger, Kara L. Britt
Publikováno v:
Stem Cell Reports, Vol 8, Iss 2, Pp 417-431 (2017)
Estrogen stimulates breast development during puberty and mammary tumors in adulthood through estrogen receptor-α (ERα). These effects are proposed to occur via ERα+ luminal cells and not the mammary stem cells (MaSCs) that are ERαneg. Since ERα
Externí odkaz:
https://doaj.org/article/451b048dd31a4d51af09091027b98444
Autor:
Tanner B, Jefferson, Tianyuan, Wang, Wendy N, Jefferson, Yin, Li, Katherine J, Hamilton, Paul A, Wade, Carmen J, Williams, Kenneth S, Korach
Publikováno v:
Epigenetics. 18
Clinically, developmental exposure to the endocrine disrupting chemical, diethylstilboestrol (DES), results in long-term male and female infertility. Experimentally, developmental exposure to DES results in abnormal reproductive tract phenotypes in m
Autor:
Yukitomo Arao, Artiom Gruzdev, Gregory J Scott, Manas K Ray, Lauren J Donoghue, Thomas I Neufeld, Sydney L Lierz, Megan L Stefkovich, Emilie Mathura, Tanner Jefferson, Julie F Foley, Beth W Mahler, Arvand Asghari, Courtney Le, Bradley K McConnell, Robert Stephen, Brian R Berridge, Katherine J Hamilton, Sylvia C Hewitt, Michihisa Umetani, Kenneth S Korach
Publikováno v:
J Endocr Soc
Nongenomic effects of estrogen receptor α (ERα) signaling have been described for decades. Several distinct animal models have been generated previously to analyze the nongenomic ERα signaling (eg, membrane-only ER, and ERαC451A). However, the me
Publikováno v:
FASEB J
Estrogen receptor alpha (ERα) is a ligand-dependent transcription regulator, containing two transactivation functional domains, AF-1 and AF-2. The selective estrogen receptor modulators (SERMs), including 4-hydroxytamoxifen (4OHT), activate AF-1 pre
Autor:
Artiom Gruzdev, Marleny Garcia, Sara A. Grimm, Kenneth S. Korach, Katherine J. Hamilton, Francesco J. DeMayo, Sydney L. Lierz, Sylvia C. Hewitt, John P. Lydon
Publikováno v:
Journal of Biological Chemistry. 294:9746-9759
Insulin-like growth factor 1 (IGF1) is primarily synthesized in and secreted from the liver; however, estrogen (E2), through E2 receptor α (ERα), increases uterine Igf1 mRNA levels. Previous ChIP-seq analyses of the murine uterus have revealed a po
Autor:
Katherine J. Hamilton, Yukitomo Arao, Kenneth S. Korach, Francesco J. DeMayo, Ming-Jer Tsai, San-Pin Wu
Publikováno v:
The FASEB Journal. 33:7375-7386
Polycystic ovary syndrome (PCOS) is a hypothalamic-pituitary-gonadal (HPG) axis disorder. PCOS symptoms most likely result from a disturbance in the complex feedback regulation system of the HPG axis, which involves gonadotrophic hormones and ovarian
Publikováno v:
Molecular Metabolism, Vol 18, Iss, Pp 68-78 (2018)
Molecular Metabolism
Molecular Metabolism
Objective Studies using the estrogen receptor alpha (ERα) knock-out (αERKO) mice have demonstrated that ERα plays a crucial role in various estrogen-mediated metabolic regulations. ERα is a ligand dependent transcription regulator and its activit
Autor:
Lalith Perera, Kevin Gerrish, Austin X Zhang, Jian-Liang Li, Emilie Mathura, Katherine J. Hamilton, Tanner B. Jefferson, Kenneth S. Korach, Tianyuan Wang, Yin Li, Negin P. Martin, Laura Wharey, Artiom Gruzdev
Publikováno v:
Endocrinology
Estrogen insensitivity syndrome (EIS) arises from rare mutations in estrogen receptor-α (ERα, encoded by ESR1 gene) resulting in the inability of estrogen to exert its biological effects. Due to its rarity, mutations in ESR1 gene and the underlying