Výsledky vyhledávání - "Katherine J, Ladner"

Akademický článek

NFκB signaling in alveolar rhabdomyosarcoma

Autor: Megan M. Cleary, Atiya Mansoor, Teagan Settelmeyer, Yuichi Ijiri, Katherine J. Ladner, Matthew N. Svalina, Brian P. Rubin, Denis C. Guttridge, Charles Keller

Publikováno v: Disease Models & Mechanisms, Vol 10, Iss 9, Pp 1109-1115 (2017)

Alveolar rhabdomyosarcoma (aRMS) is a pediatric soft tissue cancer commonly associated with a chromosomal translocation that leads to the expression of a Pax3:Foxo1 or Pax7:Foxo1 fusion protein, the developmental underpinnings of which may give clues

Externí odkaz: https://doaj.org/article/482fff5d3d17486dbea30258167b2d1d

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Akademický článek

MyoD Regulates Skeletal Muscle Oxidative Metabolism Cooperatively with Alternative NF-κB

Autor: Jonathan Shintaku, Jennifer M. Peterson, Erin E. Talbert, Jin-Mo Gu, Katherine J. Ladner, Dustin R. Williams, Kambiz Mousavi, Ruoning Wang, Vittorio Sartorelli, Denis C. Guttridge

Publikováno v: Cell Reports, Vol 17, Iss 2, Pp 514-526 (2016)

MyoD is a key regulator of skeletal myogenesis that directs contractile protein synthesis, but whether this transcription factor also regulates skeletal muscle metabolism has not been explored. In a genome-wide ChIP-seq analysis of skeletal muscle ce

Externí odkaz: https://doaj.org/article/4a436be3d23f49989082e1f87fce1083

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Data from IFN-α and Bortezomib Overcome Bcl-2 and Mcl-1 Overexpression in Melanoma Cells by Stimulating the Extrinsic Pathway of Apoptosis

Autor: William E. Carson, Page Bouchard, Denis C. Guttridge, Katherine J. Ladner, Abhik Ray Chaudhury, Gregory Young, Erinn Hade, Megan Quimper, Adrian Lewis, Nisha N. Shah, Michael R. Go, Lloyd Brown, Kristan Guenterberg, Ene T. Raig, Gregory B. Lesinski

We hypothesized that IFN-α would enhance the apoptotic activity of bortezomib on melanoma cells. Combined treatment with bortezomib and IFN-α induced synergistic apoptosis in melanoma and other solid tumor cell lines. Apoptosis was associated with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a6a756c0598a3c660fc4b241486e6889
https://doi.org/10.1158/0008-5472.c.6497240

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Supplementary Figure Legends from IFN-α and Bortezomib Overcome Bcl-2 and Mcl-1 Overexpression in Melanoma Cells by Stimulating the Extrinsic Pathway of Apoptosis

Supplementary Figure Legends from IFN-α and Bortezomib Overcome Bcl-2 and Mcl-1 Overexpression in Melanoma Cells by Stimulating the Extrinsic Pathway of Apoptosis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63ea079f24bfa81c615584434de3b88c
https://doi.org/10.1158/0008-5472.22373879.v1

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Supplementary Figures 1-8 from IFN-α and Bortezomib Overcome Bcl-2 and Mcl-1 Overexpression in Melanoma Cells by Stimulating the Extrinsic Pathway of Apoptosis

Supplementary Figures 1-8 from IFN-α and Bortezomib Overcome Bcl-2 and Mcl-1 Overexpression in Melanoma Cells by Stimulating the Extrinsic Pathway of Apoptosis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01e3af1ab1b5390fafb5dc54b8455f76
https://doi.org/10.1158/0008-5472.22373876.v1

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Akademický článek

Classical NF-κB Metabolically Reprograms Sarcoma Cells Through Regulation of Hexokinase 2

Autor: Priya Londhe, Peter Y. Yu, Yuichi Ijiri, Katherine J. Ladner, Joelle M. Fenger, Cheryl London, Peter J. Houghton, Denis C. Guttridge

Publikováno v: Frontiers in Oncology, Vol 8 (2018)

BackgroundMetabolic reprogramming has emerged as a cancer hallmark, and one of the well-known cancer-associated metabolic alterations is the increase in the rate of glycolysis. Recent reports have shown that both the classical and alternative signali

Externí odkaz: https://doaj.org/article/454ae91c45e04e6990122e03d8a55e95

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Akademický článek

TNF inhibits Notch-1 in skeletal muscle cells by Ezh2 and DNA methylation mediated repression: implications in duchenne muscular dystrophy.

Autor: Swarnali Acharyya, Sudarshana M Sharma, Alfred S Cheng, Katherine J Ladner, Wei He, William Kline, Huating Wang, Michael C Ostrowski, Tim H Huang, Denis C Guttridge

Publikováno v: PLoS ONE, Vol 5, Iss 8, p e12479 (2010)

Classical NF-kappaB signaling functions as a negative regulator of skeletal myogenesis through potentially multiple mechanisms. The inhibitory actions of TNFalpha on skeletal muscle differentiation are mediated in part through sustained NF-kappaB act

Externí odkaz: https://doaj.org/article/0e92ee6575f14848a29d382035dfab12

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NF-κB regulates GDF-15 to suppress macrophage surveillance during early tumor development

Autor: Gustavo Leone, Benjamin Swanson, Priyani Rajasekera, Ericka Haverick, Terence M. Williams, Raleigh D. Kladney, Carl Schmidt, David J. Wang, Erin E. Talbert, Jennifer M. Peterson, Nivedita M. Ratnam, Denis C. Guttridge, Mary Dillhoff, Katherine J. Ladner

Publikováno v: Journal of Clinical Investigation. 127:3796-3809

Macrophages are attracted to developing tumors and can participate in immune surveillance to eliminate neoplastic cells. In response, neoplastic cells utilize NF-κB to suppress this killing activity, but the mechanisms underlying their self-protecti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::513a5e890829e263b8abf36c5ab30756
https://doi.org/10.1172/jci91561

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NFκB signaling in alveolar rhabdomyosarcoma

Autor: Yuichi Ijiri, Denis C. Guttridge, Katherine J. Ladner, Brian P. Rubin, Matthew N. Svalina, Megan M. Cleary, Teagan P. Settelmeyer, Charles Keller, Atiya Mansoor

Publikováno v: Disease Models & Mechanisms
Disease Models & Mechanisms, Vol 10, Iss 9, Pp 1109-1115 (2017)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a892c518c67fbb0c8807f910d1189158
http://europepmc.org/articles/PMC5611971

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