Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Katherine I. Swenson-Fields"'
Autor:
Katherine I. Swenson-Fields, Christopher J. Ward, Micaila E. Lopez, Shaneann Fross, Anna L. Heimes Dillon, James D. Meisenheimer, Adib J. Rabbani, Emily Wedlock, Malay K. Basu, Kyle P. Jansson, Peter S. Rowe, Jason R. Stubbs, Darren P. Wallace, Michael P. Vitek, Timothy A. Fields
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
We and others have previously shown that the presence of renal innate immune cells can promote polycystic kidney disease (PKD) progression. In this study, we examined the influence of the inflammasome, a key part of the innate immune system, on PKD.
Externí odkaz:
https://doaj.org/article/9c08d54c8b8b492abf160be7de40df31
Autor:
Jacqueline D. Peda, Sally M. Salah, Darren P. Wallace, Patrick E. Fields, Connor J. Grantham, Timothy A. Fields, Katherine I. Swenson-Fields
Publikováno v:
Disease Models & Mechanisms, Vol 9, Iss 9, Pp 1051-1061 (2016)
Polycystic kidney disease (PKD) is characterized by slow expansion of fluid-filled cysts derived from tubules within the kidney. Cystic expansion results in injury to surrounding parenchyma and leads to inflammation, scarring and ultimately loss of r
Externí odkaz:
https://doaj.org/article/7bc7da33bfd54611a3d4efc7f0d7c3c6
Autor:
Wei Wang, Luciane M. Silva, Henry H. Wang, Matthew A. Kavanaugh, Tana S. Pottorf, Bailey A. Allard, Damon T. Jacobs, Ruochen Dong, Joseph T. Cornelius, Aakriti Chaturvedi, Katherine I. Swenson-Fields, Timothy A. Fields, Michele T. Pritchard, Madhulika Sharma, Chad Slawson, Darren P. Wallace, James P. Calvet, Pamela V. Tran
Publikováno v:
Kidney International. 102:577-591
Primary cilia are sensory organelles built and maintained by intraflagellar transport (IFT) multiprotein complexes. Deletion of several IFT-B genes attenuates polycystic kidney disease (PKD) severity in juvenile and adult autosomal dominant polycysti
Autor:
Wei Wang, Luciane M. Silva, Henry H. Wang, Matthew A. Kavanaugh, Tana S. Pottorf, Bailey A. Allard, Damon T. Jacobs, Ruochen Dong, Joseph T. Cornelius, Aakriti Chaturvedi, Katherine I. Swenson-Fields, Timothy A. Fields, Michele T. Pritchard, Madhulika Sharma, Chad Slawson, Darren P. Wallace, James P. Calvet, Pamela V. Tran
Publikováno v:
Kidney International. 103:429
Autor:
Timothy A. Fields, Xiaogang Li, Dawson Foster, Xia Zhou, Xiaoyan Li, Katherine I. Swenson-Fields, Julian Vallejo, Jacqueline D. Peda, Reena Rao, Darren P. Wallace, Sally M. Salah, Michael J. Wacker, James D. Meisenheimer
Publikováno v:
Am J Physiol Renal Physiol
Polycystic kidney disease (PKD) is characterized by slowly expanding renal cysts that damage the kidney, typically resulting in renal failure by the fifth decade. The most common cause of death in these patients, however, is cardiovascular disease. E
Autor:
Cristian Coarfa, Ruonan Zhao, Fariba Behbod, Aria Sabbagh, Ossama Tawfik, Katherine I. Swenson-Fields, Rashna Madan, Diane L. Persons, Shixia Huang, Darlene Limback, Haleigh E. Harper, Timothy A. Fields, Yan Hong, Hanan S. Elsarraj, Susan G. Hilsenbeck, Joseph D. Fontes, Andrew K. Godwin, Dean P. Edwards, Linzi Oppenheimer, Stephanie C Bishop, Ashley L. Ellis, Ben Fangman, Jenna Berger, Anna Tsimelzon, Jeffrey Thompson, Fang Fan, Christy R. Hagan
Publikováno v:
NPJ Breast Cancer
npj Breast Cancer, Vol 6, Iss 1, Pp 1-14 (2020)
npj Breast Cancer, Vol 6, Iss 1, Pp 1-14 (2020)
The molecular processes by which some human ductal carcinoma in situ (DCIS) lesions advance to the more aggressive form, while others remain indolent, are largely unknown. Experiments utilizing a patient-derived (PDX) DCIS Mouse INtraDuctal (MIND) an
Autor:
Timothy A. Fields, Katherine I. Swenson-Fields, Jacqueline D. Peda, Patrick E. Fields, Sally M. Salah, Darren P. Wallace, Connor J. Grantham
Publikováno v:
Disease Models & Mechanisms, Vol 9, Iss 9, Pp 1051-1061 (2016)
Disease Models & Mechanisms
Disease Models & Mechanisms
Polycystic kidney disease (PKD) is characterized by slow expansion of fluid-filled cysts derived from tubules within the kidney. Cystic expansion results in injury to surrounding parenchyma and leads to inflammation, scarring and ultimately loss of r
Autor:
Timothy A. Fields, Katherine I. Swenson-Fields, Patrick J. Casey, Patrick J. Kelly, Laura N. Stemmle, Jessica Rossol-Allison, Shannon J. McCall, Patrick E. Fields
Publikováno v:
Cellular Signalling. 21:1559-1568
Wnt proteins constitute a family of secreted signaling molecules that regulate highly conserved pathways essential for development and, when aberrantly activated, drive oncogenesis in a number of human cancers. A key feature of the most widely studie
Autor:
Ying Yao, Lucy X. Fan, Katherine I. Swenson-Fields, Li Chen, Alan S.L. Yu, Mihaela Gadjeva, Darren P. Wallace, Xia Zhou, Xiaogang Li, Jared J. Grantham, Dorien J.M. Peters
Publikováno v:
Journal of Clinical Investigation, 125(6), 2399-2412
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by renal cyst formation, inflammation, and fibrosis. Macrophages infiltrate cystic kidneys, but the role of these and other inflammatory factors in disease progression are poorly u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96beab473af407001af4ddf29112b47e
https://hdl.handle.net/1887/105545
https://hdl.handle.net/1887/105545
Publikováno v:
Nature reviews. Nephrology. 7(10)
The weight of evidence gathered from studies in humans with hereditary polycystic kidney disease (PKD)1 and PKD2 disorders, as well as from experimental animal models, indicates that cysts are primarily responsible for the decline in glomerular filtr