Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Katherine I. O'Rourke"'
Autor:
Gordon B Mitchell, Christina J Sigurdson, Katherine I O'Rourke, James Algire, Noel P Harrington, Ines Walther, Terry R Spraker, Aru Balachandran
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e39055 (2012)
Chronic wasting disease (CWD), a transmissible spongiform encephalopathy of cervids, remains prevalent in North American elk, white-tailed deer and mule deer. A natural case of CWD in reindeer (Rangifer tarandus tarandus) has not been reported despit
Externí odkaz:
https://doaj.org/article/d724dbf07ef348f3893bf94d3d42abdc
Autor:
Katherine I. O'Rourke, Mehmet Ulas Cinar, Stephen N. White, David A. Schneider, D. F. Waldron
Publikováno v:
The Veterinary Journal. 233:19-24
Scrapie is a transmissible spongiform encephalopathy of sheep and goats, and scrapie eradication programs in many parts of the world rely on strong genetic resistance to classical scrapie in sheep. However, the utility of putative resistance alleles
Autor:
Katherine I. O'Rourke, William H Edwards, Ryan J. Monello, Mary E Wood, Nathan L. Galloway, Jenny G. Powers, Sally A. Madsen-Bouterse, Margaret A. Wild
Publikováno v:
Proceedings of the National Academy of Sciences. 114:12208-12212
Pathogens can exert a large influence on the evolution of hosts via selection for alleles or genotypes that moderate pathogen virulence. Inconsistent interactions between parasites and the host genome, such as those resulting from genetic linkages an
Autor:
D. F. Waldron, Stephen N. White, Katherine I. O'Rourke, Mehmet Ulas Cinar, David A. Schneider
Scrapie is the transmissible spongiform encephalopathy (TSE) of sheep and goats, and it can be transmitted in both directions between these species. Scrapie eradication programs worldwide have utilized strong genetic resistance to classical scrapie i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0941506a725d0e3f633bef058eea479b
https://europepmc.org/articles/PMC6285477/
https://europepmc.org/articles/PMC6285477/
Autor:
Rohana P. Dassanayake, Katherine I. O'Rourke, Sally A. Madsen-Bouterse, Dongyue Zhuang, Aru Balachandran, Gordon Mitchell, David A. Schneider
Publikováno v:
The Journal of General Virology
Development of mice expressing either ovine (Tg338) or cervid (TgElk) prion protein (PrP) have aided in characterization of scrapie and chronic wasting disease (CWD), respectively. Experimental inoculation of sheep with CWD prions has demonstrated th
Autor:
Thomas C. Truscott, David A. Schneider, Katherine I. O'Rourke, Rohana P. Dassanayake, Sally A. Madsen-Bouterse, Dongyue Zhuang
Publikováno v:
Prion. 10:153-164
To assess scrapie infectivity associated with caprine-origin tissues, bioassay can be performed using kids, lambs or transgenic mice expressing caprine or ovine prion (PRNP) alleles, but the incubation periods are fairly long. Although several classi
Autor:
Nicholas J. Haley, Kristen A. Davenport, Jürgen A. Richt, Rachel Rielinger, Katherine I. O'Rourke, Gordon Mitchell
Publikováno v:
The Journal of general virology. 98(11)
In mammals, susceptibility to prion infection is primarily modulated by the host’s cellular prion protein (PrPC) sequence. In the sheep scrapie model, a graded scale of susceptibility has been established both in vivo and in vitro based on PrPC ami
Autor:
David A. Schneider, Dongyue Zhuang, Katherine I. O'Rourke, Thomas C. Truscott, Sally A. Madsen-Bouterse, Rohana P. Dassanayake
Publikováno v:
The Journal of General Virology
The placenta of domestic sheep plays a key role in horizontal transmission of classical scrapie. Domestic goats are frequently raised with sheep and are susceptible to classical scrapie, yet potential routes of transmission from goats to sheep are no
Autor:
Jenny G. Powers, Aru Balachandran, Terry R. Spraker, Bruce A. Cummings, Tracy A. Nichols, Thomas Gidlewski, Margaret A. Wild, Katherine I. O'Rourke, Kurt C. VerCauteren
Publikováno v:
Journal of Veterinary Diagnostic Investigation. 27:431-441
The purpose of our study was to describe the progressive accumulation of the abnormal conformer of the prion protein (PrPCWD) and spongiform degeneration in a single section of brain stem in Rocky Mountain elk ( Cervus elaphus nelsoni) with chronic w
Autor:
Thomas Gidlewski, Robert W. Allen, Gordon Mitchell, David A. Schneider, James McLane, Terry R. Spraker, Aru Balachandran, Bruce V. Thomsen, Katherine I. O'Rourke, Delwyn P. Keane, Alex A. McIsaac
Publikováno v:
Journal of Veterinary Diagnostic Investigation. 24:878-887
An effective live animal diagnostic test is needed to assist in the control of chronic wasting disease (CWD), which has spread through captive and wild herds of white-tailed deer ( Odocoileus virginianus) in Canada and the United States. In the prese