Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Katherine Henzler‐Wildman"'
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Plant defensins including Medicago Sativa defensin 1 (MsDef1) are cysteine-rich antifungal peptides which are known for potent broad-spectrum antifungal activity against bacterial or fungal pathogens of plants. The antimicrobial activities of these c
Externí odkaz:
https://doaj.org/article/0dd17659bffa41ac9a5190e4724289b7
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
NaK is a bacterial non-selective cation channel. Here, the authors use solution NMR to show that selectivity filter (SF) in NaK is dynamic, with structural differences between the Na+ and K + -bound states. The conformation of the SF is communicated
Externí odkaz:
https://doaj.org/article/7c90fde76ebb41de9314e36553e0e237
Autor:
Nathan H. Murray, Adam Lewis, Juan P. Rincon Pabon, Michael L. Gross, Katherine Henzler-Wildman, David J. Pagliarini
Publikováno v:
ACS chemical biology. 17(8)
COQ8A is an atypical kinase-like protein that aids the biosynthesis of coenzyme Q, an essential cellular cofactor and antioxidant. COQ8A's mode of action remains unclear, in part due to the lack of small molecule tools to probe its function. Here, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13f23b4f7d078ec6708423056cce1cff
https://pubmed.ncbi.nlm.nih.gov/35904798
https://pubmed.ncbi.nlm.nih.gov/35904798
Publikováno v:
Physiology. 38
Multidrug efflux pumps export drugs by primary or secondary active transport and pose great challenges in antibiotic resistance and cancer biology. Understanding molecular transport is necessary to inhibit or even reverse the action of these proteins
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6560ce243d590318e724aa1c0729468b
https://doi.org/10.1152/physiol.2023.38.s1.5787819
https://doi.org/10.1152/physiol.2023.38.s1.5787819
Publikováno v:
The Journal of general physiology. 154(12)
A critical part of ion channel function is the ability to open and close in response to stimuli and thus conduct ions in a regulated fashion. While x-ray diffraction studies of ion channels suggested a general steric gating mechanism located at the h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::508fc64f9b2124b4481e940389c8f65c
https://pubmed.ncbi.nlm.nih.gov/36326620
https://pubmed.ncbi.nlm.nih.gov/36326620
Autor:
Nathan Murray, Adam Lewis, Christopher Asquith, Juan Rincon Pabon, Zixiang Fang, Naomi Ptak, Robert Smith, Craig Bingman, Michael Gross, Katherine Henzler‐Wildman, David Pagliarini
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e61e6b7a93d38072a500a35bd522ceda
https://doi.org/10.1096/fasebj.2022.36.s1.r3719
https://doi.org/10.1096/fasebj.2022.36.s1.r3719
A critical part of ion channel function is the ability to open and close in response to stimuli, and thus conduct ions in a regulated fashion. While X-ray diffraction studies of ion channels suggested a general steric gating mechanism located at the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30d0d70bd09cecedab96005a54b6495d
https://doi.org/10.1101/2022.04.18.488652
https://doi.org/10.1101/2022.04.18.488652
Autor:
Nathan H. Murray, Adam Lewis, Christopher R. M. Asquith, Juan P. Rincon Pabon, Zixiang Fang, Naomi Ptak, Robert W. Smith, James D. Vasta, Chad A. Zimprich, Cesear R. Corona, Matthew B. Robers, Craig A. Bingman, Michael L. Gross, Katherine Henzler-Wildman, David J. Pagliarini
Small molecule tools have enabled mechanistic investigations and therapeutic targeting of the protein kinase-like (PKL) superfamily. However, such tools are still lacking for many PKL members, including the highly conserved and disease-related UbiB f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::890a547dcd8a5a8bec39b5c8713faef6
https://doi.org/10.1101/2022.03.22.485346
https://doi.org/10.1101/2022.03.22.485346
Publikováno v:
Science. 2/10/2023, Vol. 379 Issue 6632, p592-609. 18p. 5 Color Photographs.
Autor:
Hannes Berg, Maria A. Wirtz Martin, Nadide Altincekic, Islam Alshamleh, Jasleen Kaur Bains, Julius Blechar, Betül Ceylan, Vanessa de Jesus, Karthikeyan Dhamotharan, Christin Fuks, Santosh L. Gande, Bruno Hargittay, Katharina F. Hohmann, Marie T. Hutchison, Sophie Marianne Korn, Robin Krishnathas, Felicitas Kutz, Verena Linhard, Tobias Matzel, Nathalie Meiser, Anna Niesteruk, Dennis J. Pyper, Linda Schulte, Sven Trucks, Kamal Azzaoui, Marcel J. J. Blommers, Yojana Gadiya, Reagon Karki, Andrea Zaliani, Philip Gribbon, Marcius da Silva Almeida, Cristiane Dinis Anobom, Anna L. Bula, Matthias Bütikofer, Ícaro Putinhon Caruso, Isabella Caterina Felli, Andrea T. Da Poian, Gisele Cardoso de Amorim, Nikolaos K. Fourkiotis, Angelo Gallo, Dhiman Ghosh, Francisco Gomes‐Neto, Oksana Gorbatyuk, Bing Hao, Vilius Kurauskas, Lauriane Lecoq, Yunfeng Li, Nathane Cunha Mebus‐Antunes, Miguel Mompeán, Thais Cristtina Neves‐Martins, Martí Ninot‐Pedrosa, Anderson S. Pinheiro, Letizia Pontoriero, Yulia Pustovalova, Roland Riek, Angus J. Robertson, Marie Jose Abi Saad, Miguel Á. Treviño, Aikaterini C. Tsika, Fabio C. L. Almeida, Ad Bax, Katherine Henzler‐Wildman, Jeffrey C. Hoch, Kristaps Jaudzems, Douglas V. Laurents, Julien Orts, Roberta Pierattelli, Georgios A. Spyroulias, Elke Duchardt‐Ferner, Jan Ferner, Boris Fürtig, Martin Hengesbach, Frank Löhr, Nusrat Qureshi, Christian Richter, Krishna Saxena, Andreas Schlundt, Sridhar Sreeramulu, Anna Wacker, Julia E. Weigand, Julia Wirmer‐Bartoschek, Jens Wöhnert, Harald Schwalbe
Publikováno v:
Angew Chem Int Ed Engl.
12 pags., 4 figs., 3 tabs.
SARS-CoV-2 (SCoV2) and its variants of concern pose serious challenges to the public health. The variants increased challenges to vaccines, thus necessitating for development of new intervention strategies including an
SARS-CoV-2 (SCoV2) and its variants of concern pose serious challenges to the public health. The variants increased challenges to vaccines, thus necessitating for development of new intervention strategies including an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::937814c70ed4af83744a83d3215cb85b