Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Katherine Harcourt"'
Autor:
Stephen Baker, Aishwarya Krishna, Sophie Higham, Plamena Naydenova, Siobhan O’Leary, Josefin Bartholdson Scott, Katherine Harcourt, Sally Forrest, David Goulding, To Nguyen Thi Nguyen, Nguyen Duc Toan, Elizaveta Alekseeva, Qingqing Zhou, Ilaria Andreozzi, Barbara Sobotic, Hannah Craig, Vivian Wong, Nichola Forrest-Owen, Dana Moreno Sanchez, Claire Pearce, Leah Roberts, Simon Watson, Simon Clare, Mili Estee Torok, Gordon Dougan, Paul Kellam, John S. Tregoning, Stephen T. Reece
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract The use of monoclonal antibodies for the control of drug resistant nosocomial bacteria may alleviate a reliance on broad spectrum antimicrobials for treatment of infection. We identify monoclonal antibodies that may prevent infection caused
Externí odkaz:
https://doaj.org/article/61a68b7e9f41452c92f657bdd46b3b43
Autor:
Adam J. Roberts, Han Boon Ong, Simon Clare, Cordelia Brandt, Katherine Harcourt, Yegnasew Takele, Prakash Ghosh, Angela Toepp, Max Waugh, Daniel Matano, Anna Färnert, Emily Adams, Javier Moreno, Margaret Mbuchi, Christine Petersen, Dinesh Mondal, Pascale Kropf, Gavin J. Wright
Publikováno v:
mBio, Vol 15, Iss 5 (2024)
ABSTRACTVisceral leishmaniasis is a deadly infectious disease and is one of the world’s major neglected health problems. Because the symptoms of infection are similar to other endemic diseases, accurate diagnosis is crucial for appropriate treatmen
Externí odkaz:
https://doaj.org/article/67ae2e30573840219d270dc46cf08f7c
Autor:
Ondrej Suchanek, John R. Ferdinand, Zewen K. Tuong, Sathi Wijeyesinghe, Anita Chandra, Ann-Katrin Clauder, Larissa N. Almeida, Simon Clare, Katherine Harcourt, Christopher J. Ward, Rachael Bashford-Rogers, Trevor Lawley, Rudolf A. Manz, Klaus Okkenhaug, David Masopust, Menna R. Clatworthy
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract B cells play a central role in humoral immunity but also have antibody-independent functions. Studies to date have focused on B cells in blood and secondary lymphoid organs but whether B cells reside in non-lymphoid organs (NLO) in homeostas
Externí odkaz:
https://doaj.org/article/c0d8e43c40604f7b822a7676214f0253
Autor:
Lyra O Randzavola, Paige M Mortimer, Emma Garside, Elizabeth R Dufficy, Andrea Schejtman, Georgia Roumelioti, Lu Yu, Mercedes Pardo, Kerstin Spirohn, Charlotte Tolley, Cordelia Brandt, Katherine Harcourt, Esme Nichols, Mike Nahorski, Geoff Woods, James C Williamson, Shreehari Suresh, John M Sowerby, Misaki Matsumoto, Celio XC Santos, Cher Shen Kiar, Subhankar Mukhopadhyay, William M Rae, Gordon J Dougan, John Grainger, Paul J Lehner, Michael A Calderwood, Jyoti Choudhary, Simon Clare, Anneliese Speak, Giorgia Santilli, Alex Bateman, Kenneth GC Smith, Francesca Magnani, David C Thomas
Publikováno v:
eLife, Vol 11 (2022)
EROS (essential for reactive oxygen species) protein is indispensable for expression of gp91phox, the catalytic core of the phagocyte NADPH oxidase. EROS deficiency in humans is a novel cause of the severe immunodeficiency, chronic granulomatous dise
Externí odkaz:
https://doaj.org/article/1b48b81ab31e44d4a2884318ac761009
Autor:
Kevin J. Roberts, Marion F. Cubitt, Timothy M. Carlton, Lurdes Rodrigues-Duarte, Luana Maggiore, Ray Chai, Simon Clare, Katherine Harcourt, Thomas T. MacDonald, Keith P. Ray, Anna Vossenkämper, Michael R. West, J. Scott Crowe
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Anti-TNFα and anti-IL-23 antibodies are highly effective therapies for Crohn’s disease or ulcerative colitis in a proportion of patients. V56B2 is a novel bispecific domain antibody in which a llama-derived IL-23p19-specific domain antibo
Externí odkaz:
https://doaj.org/article/1e2fe779b63b4101b684f9f331edf0fd
Autor:
Alba Cortés, John Martin, Bruce A Rosa, Klara A Stark, Simon Clare, Catherine McCarthy, Katherine Harcourt, Cordelia Brandt, Charlotte Tolley, Trevor D Lawley, Makedonka Mitreva, Matthew Berriman, Gabriel Rinaldi, Cinzia Cantacessi
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 16, Iss 10, p e0010878 (2022)
Increasing evidence shows that the host gut microbiota might be involved in the immunological cascade that culminates with the formation of tissue granulomas underlying the pathophysiology of hepato-intestinal schistosomiasis. In this study, we inves
Externí odkaz:
https://doaj.org/article/2f734bc1a5e143bc8d3116a37f7fc078
Vivaxin genes encode highly immunogenic, non-variant antigens on the Trypanosoma vivax cell-surface.
Autor:
Alessandra Romero-Ramirez, Aitor Casas-Sánchez, Delphine Autheman, Craig W Duffy, Cordelia Brandt, Simon Clare, Katherine Harcourt, Marcos Rogério André, Kayo José Garcia de Almeida Castilho Neto, Marta M G Teixeira, Rosangela Zacharias Machado, Janine Coombes, Robin J Flynn, Gavin J Wright, Andrew P Jackson
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 16, Iss 9, p e0010791 (2022)
Trypanosoma vivax is a unicellular hemoparasite, and a principal cause of animal African trypanosomiasis (AAT), a vector-borne and potentially fatal livestock disease across sub-Saharan Africa. Previously, we identified diverse T. vivax-specific gene
Externí odkaz:
https://doaj.org/article/89483fc1415d498f90bc0e90ff0c6551
Autor:
Adam Roberts, Rupa Nagar, Cordelia Brandt, Katherine Harcourt, Simon Clare, Michael A. J. Ferguson, Gavin J. Wright
Publikováno v:
mBio, Vol 13, Iss 3 (2022)
ABSTRACT Visceral leishmaniasis is a deadly infectious disease caused by Leishmania donovani, a kinetoplastid parasite for which no licensed vaccine is available. To identify potential vaccine candidates, we systematically identified genes encoding p
Externí odkaz:
https://doaj.org/article/6ee10168e049486aa4ff08e04fd53677
Autor:
Adam J Roberts, Han B Ong, Simon Clare, Cordelia Brandt, Katherine Harcourt, Susanne U Franssen, James A Cotton, Nicole Müller-Sienerth, Gavin J Wright
Publikováno v:
PLoS Pathogens, Vol 18, Iss 2, p e1010364 (2022)
Leishmaniasis is an infectious disease caused by protozoan parasites belonging to the genus Leishmania for which there are no approved human vaccines. Infections localise to different tissues in a species-specific manner with the visceral form of the
Externí odkaz:
https://doaj.org/article/96d36f9863694b608b562da01b02fe21
Autor:
Sandra Van Puyvelde, Derek Pickard, Koen Vandelannoote, Eva Heinz, Barbara Barbé, Tessa de Block, Simon Clare, Eve L. Coomber, Katherine Harcourt, Sushmita Sridhar, Emily A. Lees, Nicole E. Wheeler, Elizabeth J. Klemm, Laura Kuijpers, Lisette Mbuyi Kalonji, Marie-France Phoba, Dadi Falay, Dauly Ngbonda, Octavie Lunguya, Jan Jacobs, Gordon Dougan, Stijn Deborggraeve
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Invasive non-typhoidal Salmonella (iNTS) infections are dominated by antibiotic resistant isolates of the sequence type (ST) 313. Here, the authors identify the ST313 sublineage II.1 in the Democratic Republic of the Congo exhibiting extensive drug r
Externí odkaz:
https://doaj.org/article/d03041f0c2d4477dbba22683cea763a0