Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Katherine H. Schreiber"'
Autor:
Katherine H. Schreiber, Sebastian I. Arriola Apelo, Deyang Yu, Jacqueline A. Brinkman, Michael C. Velarde, Faizan A. Syed, Chen-Yu Liao, Emma L. Baar, Kathryn A. Carbajal, Dawn S. Sherman, Denise Ortiz, Regina Brunauer, Shany E. Yang, Stelios T. Tzannis, Brian K. Kennedy, Dudley W. Lamming
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Rapamycin extends lifespan in model organisms by targeting mTORC1, but exerts off-target side effects via inhibition of mTORC2. Here, the authors report the identification of a selective mTORC1 inhibitor, and show that it inhibits mTORC1 activity bot
Externí odkaz:
https://doaj.org/article/62fe1b728b0148059e306c8857df6c69
Autor:
Michelle E. Ehrlich, Lisa M. Ellerby, Jesse Simons, Alejandro Lopez-Ramirez, Katherine H. Schreiber, Maria A. Sanchez, Swati Naphade, Stephen M. Scheeler, Ningzhe Zhang, Kuruwitage Lakshika Madushani, Jordi Creus-Muncunill, Felix Hausch, Stanislav Moroz, Barbara J. Bailus, Brian K. Kennedy, Ashley Loureiro, Kizito-Tshitoko Tshilenge
Publikováno v:
Autophagy
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Current disease-modifying therapies for Huntington disease (HD) focus on lowering mutant HTT (huntingtin; mHTT) levels, and the immunosuppressant drug rapamycin is an intriguing therapeutic for aging and neurological disorders. Rapamycin interacts wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fb7bad532826490e340f5202a46af51
https://pubmed.ncbi.nlm.nih.gov/34024231
https://pubmed.ncbi.nlm.nih.gov/34024231
Autor:
Lucia C. Strader, Joseph M. Jez, Ildoo Hwang, Katherine H. Schreiber, Natalie M. Clark, Soeun Han, Hongwei Jing, David A. Korasick, Ryan J. Emenecker, Rosangela Sozzani, Alex S. Holehouse, Samantha K. Powers, Rohit V. Pappu, Eric Tycksen
Publikováno v:
Mol Cell
The phytohormone auxin plays crucial roles in nearly every aspect of plant growth and development. The AUXIN RESPONSE FACTOR (ARF) transcription factor family regulates auxin-responsive gene expression and exhibit nuclear localization in regions of h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe893d55638cd51f9b2bf91f06e6018b
https://doi.org/10.1016/j.molcel.2019.06.044
https://doi.org/10.1016/j.molcel.2019.06.044
Autor:
Vivian L. MacKay, Katherine H. Schreiber, Michael G Garelick, Warren C. Ladiges, Brian K. Kennedy, Aya Yanagida, Emmeline C. Academia
Publikováno v:
Cell Cycle. 12:2493-2504
Reducing activity of the mTORC1/S6K1 pathway has been shown to extend lifespan in both vertebrate and invertebrate models. For instance, both pharmacological inhibition of mTORC1 with the drug rapamycin or S6K1 knockout extends lifespan in mice. Sinc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03c01d958fe40b7f7219c4a83475d096
https://doi.org/10.4161/cc.25512
https://doi.org/10.4161/cc.25512
Publikováno v:
Cell. 152:1365-1375
When mutations in nuclear lamins were first identified in skeletal and cardiac muscle diseases, the molecular events underlying pathogenesis were mere points of speculation. As more and more unrelated diseases were linked to lamins and other nuclear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf32721a26c8353c54612afd10e50677
https://doi.org/10.1016/j.cell.2013.02.015
https://doi.org/10.1016/j.cell.2013.02.015
The target of rapamycin (TOR) signaling pathway acts as a molecular switch to regulate cellular growth and proliferation in response to nutrients. This pathway is implicated in a number of pathological conditions, including cancer, metabolic disease,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af4a56072885b44208e215aa7b85d888
https://doi.org/10.1016/b978-0-12-411596-5.00002-2
https://doi.org/10.1016/b978-0-12-411596-5.00002-2
Autor:
Rolf Bodmer, Rochelle Buffenstein, Hao Cheng, Ying-Ann Chiao, Miook Cho, Eileen M. Crimmins, Dao-Fu Dai, João Pedro de Magalhães, James F. Fries, William Giblin, Vera Gorbunova, Jing-Dong J Han, David E. Harrison, Ingrid A. Harten, Lei Hou, F. Brad Johnson, Matt R. Kaeberlein, Brian K. Kennedy, Ron Korstanje, Edward G. Lakatta, Scott F. Leiser, Morgan E. Levine, Kaitlyn N. Lewis, David B. Lombard, Hillary A. Miller, Richard A. Miller, Robert E. Monticone, Shannon J. Moore, Ludmila Müller, Geoffrey G. Murphy, Nancy L. Nadon, Monique N. O’Leary, Michelle Olive, Graham Pawelec, Scott D. Pletcher, Peter S. Rabinovitch, Katherine H. Schreiber, Andrei Seluanov, Shufei Song, Randy Strong, Yousin Suh, George L. Sutphin, Hazel H. Szeto, Robi Tacutu, Michael Van Meter, Dan Wang, Mingyi Wang, Michael J. Waterson, Robert J. Wessells, Thomas N. Wight, Bo Xian, Ting-Lin B. Yang
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::098dc2eb0fb4119b70ce5e826d9ef5cd
https://doi.org/10.1016/b978-0-12-411596-5.00028-9
https://doi.org/10.1016/b978-0-12-411596-5.00028-9
Autor:
Rebeccah Riley, Julie K. Andersen, Heinrich Jasper, Monique N. O’Leary, Jason R. Rock, Samantha Haller, Joseph T. Rodgers, Simon Melov, Subir Kapuria, Thomas A. Rando, Katherine H. Schreiber, Brian K. Kennedy, Jianwen Que
Publikováno v:
Cell Stem Cell. 21:806-818.e5
The balance between self-renewal and differentiation ensures long-term maintenance of stem cell (SC) pools in regenerating epithelial tissues. This balance is challenged during periods of high regenerative pressure and is often compromised in aged an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afd94d2453fbea9911f96842165f5fa7
https://doi.org/10.1016/j.stem.2017.11.008
https://doi.org/10.1016/j.stem.2017.11.008
Autor:
Katherine H. Schreiber, Chen-Yu Liao, Emmeline C. Academia, Denise Ortiz, Brian K. Kennedy, Arieanna C. Anies
Publikováno v:
Aging Cell
The mechanism by which the drug rapamycin inhibits the mechanistic target of rapamycin (mTOR) is of intense interest because of its likely relevance in cancer biology, aging, and other age-related diseases. While rapamycin acutely and directly inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a9ec5f57f8c661d2114d965b74105ec
https://pubmed.ncbi.nlm.nih.gov/25652038
https://pubmed.ncbi.nlm.nih.gov/25652038
Autor:
Katarzyna A. Broniowska, Bryndon J. Oleson, Katherine H. Schreiber, Vera L. Tarakanova, John A. Corbett
Publikováno v:
The Journal of biological chemistry. 289(16)
In this study, the effects of cytokines on the activation of the DNA double strand break repair factors histone H2AX (H2AX) and ataxia telangiectasia mutated (ATM) were examined in pancreatic β cells. We show that cytokines stimulate H2AX phosphoryl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0cea215921a4cab44c5816a2a201866
https://pubmed.ncbi.nlm.nih.gov/24610783
https://pubmed.ncbi.nlm.nih.gov/24610783