Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Katherine H O'Toole"'
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114631- (2024)
Summary: Enzymatic modification of DNA nucleobases can coordinate gene expression, nuclease protection, or mutagenesis. We recently discovered a clade of phage-specific cytosine methyltransferase (MT) and 5-methylpyrimidine dioxygenase (5mYOX) enzyme
Externí odkaz:
https://doaj.org/article/c8f444b68e274589a3de00d1688c4e19
Autor:
Valérie de Crécy-lagard, Rocio Amorin de Hegedus, Cecilia Arighi, Jill Babor, Alex Bateman, Ian Blaby, Crysten Blaby-Haas, Alan J Bridge, Stephen K Burley, Stacey Cleveland, Lucy J Colwell, Ana Conesa, Christian Dallago, Antoine Danchin, Anita de Waard, Adam Deutschbauer, Raquel Dias, Yousong Ding, Gang Fang, Iddo Friedberg, John Gerlt, Joshua Goldford, Mark Gorelik, Benjamin M Gyori, Christopher Henry, Geoffrey Hutinet, Marshall Jaroch, Peter D Karp, Liudmyla Kondratova, Zhiyong Lu, Aron Marchler-Bauer, Maria-Jesus Martin, Claire McWhite, Gaurav D Moghe, Paul Monaghan, Anne Morgat, Christopher J Mungall, Darren A Natale, William C Nelson, Seán O’Donoghue, Christine Orengo, Katherine H O’Toole, Predrag Radivojac, Colbie Reed, Richard J Roberts, Dmitri Rodionov, Irina A Rodionova, Jeffrey D Rudolf, Lana Saleh, Gloria Sheynkman, Francoise Thibaud-Nissen, Paul D Thomas, Peter Uetz, David Vallenet, Erica Watson Carter, Peter R Weigele, Valerie Wood, Elisha M Wood-Charlson, Jin Xu
Valérie de Crécy-Lagard: et al.
Over the last 25 years, biology has entered the genomic era and is becoming a science of 'big data'. Most interpretations of genomic analyses rely on accurate functional annotations of the proteins encoded by mo
Over the last 25 years, biology has entered the genomic era and is becoming a science of 'big data'. Most interpretations of genomic analyses rely on accurate functional annotations of the proteins encoded by mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92bc0c0dc223190e4e256e36b3167003
Autor:
Christine M Harvey, Debra Dunaway-Mariano, Chunliang Liu, Karen N. Allen, Katherine H O'Toole, Patrick S. Mariano
Publikováno v:
Biochemistry. 59:3247-3257
Trehalose-6-phosphate phosphatase (T6PP) catalyzes the dephosphorylation of trehalose 6-phosphate (T6P) to the disaccharide trehalose. The enzyme is not present in mammals but is essential to the viability of multiple lower organisms as trehalose is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a994e55739cdb58a92df58bc4d049a63
https://doi.org/10.1021/acs.biochem.0c00317
https://doi.org/10.1021/acs.biochem.0c00317
Autor:
Lana Saleh, Yan-Jiun Lee, Zhiyi Sun, Katherine H. O’Toole, Samuel S. Rodda, Mackenzie J. Parker, Sean R. Lund, Nan Dai, Daria A. Shnider, Chudi Guan, Ivan R. Corrêa, Evan J. Burke, Malcolm R. Zeroka, Peter Weigele, David M. Hough, Dharit S. Doshi
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Chemical tailoring of canonical bases expands the functionality of DNA in the same manner that posttranscriptional and -translational modifications enhance functional diversity in RNA and proteins. We describe the activities of ten-eleve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99f4969d5a0be9c69033ec8b829e6953
https://doi.org/10.1073/pnas.2026742118
https://doi.org/10.1073/pnas.2026742118
Publikováno v:
Biochem Soc Trans
Phosphoglycosyl transferases (PGTs) play a pivotal role at the inception of complex glycoconjugate biosynthesis pathways across all domains of life. PGTs promote the first membrane-committed step in the en bloc biosynthetic strategy by catalyzing the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b0f66cac2664373f8460fcdda7ff04b
https://pubmed.ncbi.nlm.nih.gov/34100892
https://pubmed.ncbi.nlm.nih.gov/34100892
Publikováno v:
Proc Natl Acad Sci U S A
The monotopic phosphoglycosyl transferase (monoPGT) superfamily comprises over 38,000 nonredundant sequences represented in bacterial and archaeal domains of life. Members of the superfamily catalyze the first membrane-committed step in en bloc oligo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a75365cb2d3aed36cf44e50e29568c77
https://doi.org/10.1073/pnas.2018289118
https://doi.org/10.1073/pnas.2018289118
Autor:
Si Chen, Lindsey M. Easthon, Barbara Imperiali, Hanfei Yan, Martina Ralle, Tiffany W Victor, Karen N. Allen, Randy J. Smith, Lisa M. Miller, Doga Gursoy, Xiaojing Huang, Mingyuan Ge, Katherine H O'Toole, Yong S. Chu
Publikováno v:
Journal of the American Chemical Society. 142(5)
We report the application of lanthanide-binding tags (LBTs) for two- and three-dimensional X-ray imaging of individual proteins in cells with a sub-15 nm beam. The method combines encoded LBTs, which are tags of minimal size (ca. 15-20 amino acids) a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::946d73d9433630586fa8ba58a14368d5
https://pubmed.ncbi.nlm.nih.gov/31923358
https://pubmed.ncbi.nlm.nih.gov/31923358
Autor:
Yong S. Chu, Xiaojing Huang, Hanfei Yan, Randy J. Smith, Tiffany W Victor, Lisa M. Miller, Karen N. Allen, Lindsey M. Easthon, Mingyuan Ge, Katherine H O'Toole
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-8 (2018)
Scientific Reports
Scientific Reports
X-ray Fluorescence (XRF) microscopy is a growing approach for imaging the trace element concentration, distribution, and speciation in biological cells at the nanoscale. Moreover, three-dimensional nanotomography provides the added advantage of imagi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04fd558f4762690e8381710de10a02f3
http://link.springer.com/article/10.1038/s41598-018-31461-y
http://link.springer.com/article/10.1038/s41598-018-31461-y
Autor:
Leah Seebald, Barbara Imperiali, Katherine H O'Toole, Gregory Dodge, Karen N. Allen, Hannah Bernstein
Publikováno v:
The FASEB Journal. 34:1-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05ac372432c87ea83529bccee8faf623
https://doi.org/10.1096/fasebj.2020.34.s1.05269
https://doi.org/10.1096/fasebj.2020.34.s1.05269
Publikováno v:
Methods in enzymology. 607
Phosphotransferases catalyze reactions on chemically diverse molecules in organisms from all domains of life. The haloalkanoate dehalogenase superfamily (HADSF) is a model system for phosphoryl transfer enzymes as members catalyze phosphoester hydrol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6edd1681b592a1dad0b8efd1b2e0c888
https://pubmed.ncbi.nlm.nih.gov/30149857
https://pubmed.ncbi.nlm.nih.gov/30149857