Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Katherine Gowan"'
In vivo interferon-gamma induced changes in gene expression dramatically alter neutrophil phenotype.
Autor:
Daniel R Ambruso, Natalie J Briones, Angelina F Baroffio, John R Murphy, Alexander D Tran, Katherine Gowan, Bridget Sanford, Michael Ellison, Kenneth L Jones
Publikováno v:
PLoS ONE, Vol 17, Iss 2, p e0263370 (2022)
The cytokine Interferon-γ (IFN-γ) exerts powerful immunoregulatory effects on the adaptive immune system and also enhances functions of the neutrophil (PMN). The clinical use of IFN-γ has been driven by the finding that its administration to patie
Externí odkaz:
https://doaj.org/article/5560076a792640a2978e1586fa78271e
Autor:
Marisa W. Friederich, Sharita Timal, Christopher A. Powell, Cristina Dallabona, Alina Kurolap, Sara Palacios-Zambrano, Drago Bratkovic, Terry G. J. Derks, David Bick, Katelijne Bouman, Kathryn C. Chatfield, Nadine Damouny-Naoum, Megan K. Dishop, Tzipora C. Falik-Zaccai, Fuad Fares, Ayalla Fedida, Ileana Ferrero, Renata C. Gallagher, Rafael Garesse, Micol Gilberti, Cristina González, Katherine Gowan, Clair Habib, Rebecca K. Halligan, Limor Kalfon, Kaz Knight, Dirk Lefeber, Laura Mamblona, Hanna Mandel, Adi Mory, John Ottoson, Tamar Paperna, Ger J. M. Pruijn, Pedro F. Rebelo-Guiomar, Ann Saada, Bruno Sainz, Hayley Salvemini, Mirthe H. Schoots, Jan A. Smeitink, Maciej J. Szukszto, Hendrik J. ter Horst, Frans van den Brandt, Francjan J. van Spronsen, Joris A. Veltman, Eric Wartchow, Liesbeth T. Wintjes, Yaniv Zohar, Miguel A. Fernández-Moreno, Hagit N. Baris, Claudia Donnini, Michal Minczuk, Richard J. Rodenburg, Johan L. K. Van Hove
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Abstract Mitochondrial protein synthesis requires charging mt-tRNAs with their cognate amino acids by mitochondrial aminoacyl-tRNA synthetases, with the exception of glutaminyl mt-tRNA (mt-tRNAGln). mt-tRNAGln is indirectly charged by a transamidatio
Externí odkaz:
https://doaj.org/article/5e2c03b6081043e5add48aba3812d059
Autor:
Rene L. Begay, BS, Charles A. Tharp, MD, August Martin, Sharon L. Graw, PhD, Gianfranco Sinagra, MD, Daniela Miani, MD, Mary E. Sweet, BA, Dobromir B. Slavov, PhD, Neil Stafford, MD, Molly J. Zeller, Rasha Alnefaie, Teisha J. Rowland, PhD, Francesca Brun, MD, Kenneth L. Jones, PhD, Katherine Gowan, Luisa Mestroni, MD, Deborah M. Garrity, PhD, Matthew R.G. Taylor, MD, PhD
Publikováno v:
JACC: Basic to Translational Science, Vol 1, Iss 5, Pp 344-359 (2016)
A genetic etiology has been identified in 30% to 40% of dilated cardiomyopathy (DCM) patients, yet only 50% of these cases are associated with a known causative gene variant. Thus, in order to understand the pathophysiology of DCM, it is necessary to
Externí odkaz:
https://doaj.org/article/234247b2b5784c6fbf2ceca86cc593b3
Autor:
Zhangguo Chen, Mihret T. Elos, Sawanee S. Viboolsittiseri, Katherine Gowan, Sonia M. Leach, Michael Rice, Maxwell D. Eder, Kenneth Jones, Jing H. Wang
Publikováno v:
Journal of Hematology & Oncology, Vol 9, Iss 1, Pp 1-14 (2016)
Abstract Background Activated B lymphocytes harbor programmed DNA double-strand breaks (DSBs) initiated by activation-induced deaminase (AID) and repaired by non-homologous end-joining (NHEJ). While it has been proposed that these DSBs during seconda
Externí odkaz:
https://doaj.org/article/ab02e743287e4e0886e4627ff3082287
Whole exome sequencing identifies a troponin T mutation hot spot in familial dilated cardiomyopathy.
Autor:
Nzali Campbell, Gianfranco Sinagra, Kenneth L Jones, Dobromir Slavov, Katherine Gowan, Marco Merlo, Elisa Carniel, Pamela R Fain, Pierluigi Aragona, Andrea Di Lenarda, Luisa Mestroni, Matthew R G Taylor
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e78104 (2013)
Dilated cardiomyopathy (DCM) commonly causes heart failure and shows extensive genetic heterogeneity that may be amenable to newly developed next-generation DNA sequencing of the exome. In this study we report the successful use of exome sequencing t
Externí odkaz:
https://doaj.org/article/9be9e629334e4b6a9be60d6c28116889
Autor:
Robert C. Doebele, D. Ross Camidge, Dara L. Aisner, Marileila Varella-Garcia, Rafal Dziadziuszko, W. Tom Purcell, Paul A. Bunn, Daniel T. Merrick, Kurtis D. Davies, Adriana Estrada-Bernal, Andrea Doak, Laura Schubert, Kenneth Jones, Katherine Gowan, Anh T. Le, Caroline E. McCoach
ALK and ROS1 patient specific data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18af9a222f0b897a3621b3ca2dc04150
https://doi.org/10.1158/1078-0432.22464731
https://doi.org/10.1158/1078-0432.22464731
Autor:
Robert C. Doebele, D. Ross Camidge, Dara L. Aisner, Marileila Varella-Garcia, Rafal Dziadziuszko, W. Tom Purcell, Paul A. Bunn, Daniel T. Merrick, Kurtis D. Davies, Adriana Estrada-Bernal, Andrea Doak, Laura Schubert, Kenneth Jones, Katherine Gowan, Anh T. Le, Caroline E. McCoach
Supplementary Figures 1-5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3734dbeebf1122983d4ff4c2db8d96e9
https://doi.org/10.1158/1078-0432.22464740.v1
https://doi.org/10.1158/1078-0432.22464740.v1
Autor:
Robert C. Doebele, D. Ross Camidge, Dara L. Aisner, Marileila Varella-Garcia, Rafal Dziadziuszko, W. Tom Purcell, Paul A. Bunn, Daniel T. Merrick, Kurtis D. Davies, Adriana Estrada-Bernal, Andrea Doak, Laura Schubert, Kenneth Jones, Katherine Gowan, Anh T. Le, Caroline E. McCoach
Custom capture-based NGS panel of 48 genes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e5b054e1b5e92804267b281695848d2
https://doi.org/10.1158/1078-0432.22464737
https://doi.org/10.1158/1078-0432.22464737
Autor:
Robert C. Doebele, D. Ross Camidge, Dara L. Aisner, Marileila Varella-Garcia, Rafal Dziadziuszko, W. Tom Purcell, Paul A. Bunn, Daniel T. Merrick, Kurtis D. Davies, Adriana Estrada-Bernal, Andrea Doak, Laura Schubert, Kenneth Jones, Katherine Gowan, Anh T. Le, Caroline E. McCoach
Purpose: Despite initial benefit from tyrosine kinase inhibitors (TKIs), patients with advanced non–small cell lung cancer (NSCLC) harboring ALK (ALK+) and ROS1 (ROS1+) gene fusions ultimately progress. Here, we report on the potential resistance m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d732f8e4c1e50a7e0e8fdf9e84a563b
https://doi.org/10.1158/1078-0432.c.6525788
https://doi.org/10.1158/1078-0432.c.6525788
Autor:
Robert C. Doebele, D. Ross Camidge, Dara L. Aisner, Marileila Varella-Garcia, Rafal Dziadziuszko, W. Tom Purcell, Paul A. Bunn, Daniel T. Merrick, Kurtis D. Davies, Adriana Estrada-Bernal, Andrea Doak, Laura Schubert, Kenneth Jones, Katherine Gowan, Anh T. Le, Caroline E. McCoach
Read depths for ALK and ROS1 used in NGS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7882679e9d8c8dd5a517b3e3eaa87b63
https://doi.org/10.1158/1078-0432.22464734.v1
https://doi.org/10.1158/1078-0432.22464734.v1