Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Katherine F. Wallis"'
Publikováno v:
Journal of Clinical and Translational Science, Vol 5, Pp 10-11 (2021)
ABSTRACT IMPACT: Reducing methionine levels has repeatedly been shown to reduce cancer growth in vivo, while at the same time increasing lifespan in healthy animals. However, the mechanisms behind the beneficial effects of methionine restriction are
Externí odkaz:
https://doaj.org/article/edeb9baf56c842b591a40414bea15007
Autor:
Lauren C. Morehead, Sarita Garg, Katherine F. Wallis, Eric R. Siegel, Alan J. Tackett, Isabelle R. Miousse
Dietary methionine restriction, defined as reduction of methionine intake by around 80%, reproducibly decreases tumor growth and synergizes with cancer therapies. Here, we combined dietary methionine restriction with immune checkpoint inhibitors in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::817cf36761985639dd6afb276a7a9bb3
https://doi.org/10.2139/ssrn.4329452
https://doi.org/10.2139/ssrn.4329452
Autor:
Jordan T. Bird, Stephanie D. Byrum, Katherine F. Wallis, Lauren C. Morehead, Isabelle R. Miousse
Publikováno v:
Environ Mol Mutagen
Restriction of the sulfur amino acids methionine and cysteine has recently been proposed as potential adjuvant therapy in cancer. While cysteine depletion has been associated with ferroptotic cell death, methionine depletion has not. We hypothesized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbb66a59855927937c72f635e24104af
https://doi.org/10.1002/em.22428
https://doi.org/10.1002/em.22428
Autor:
Isabelle R. Miousse, Samuel G. Mackintosh, Alan J. Tackett, Stephanie D. Byrum, Allen Gies, Katherine F. Wallis, Jordan T. Bird
Dietary methionine restriction is associated with a reduction in tumor growth in preclinical studies and an increase in lifespan in animal models. The mechanism by which methionine restriction inhibits tumor growth while sparing normal cells is incom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6a01a24fd87ecd271f086e5d76cd563
https://doi.org/10.1101/2020.08.18.254490
https://doi.org/10.1101/2020.08.18.254490
Publikováno v:
Nutrients
Nutrients, Vol 12, Iss 3, p 781 (2020)
Volume 12
Issue 3
Nutrients, Vol 12, Iss 3, p 781 (2020)
Volume 12
Issue 3
Dietary methionine restriction is associated with improved health outcomes and an increase in lifespan in animal models. We have previously shown that an increase in dietary methionine induces alteration in the intestinal microbiome. The composition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c42b361235ad9404c0b12a5f9462eec
http://europepmc.org/articles/PMC7146121
http://europepmc.org/articles/PMC7146121
Publikováno v:
Journal of Clinical and Translational Science. 5:10-11
IMPACT: Reducing methionine levels has repeatedly been shown to reduce cancer growth in vivo, while at the same time increasing lifespan in healthy animals. However, the mechanisms behind the beneficial effects of methionine restriction are currently
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::efb081adb8a2fecc594eaf96843dda62
https://doi.org/10.1017/cts.2021.429
https://doi.org/10.1017/cts.2021.429
Publikováno v:
Cancer Research. 81:1577-1577
Immune checkpoint inhibitors (ICIs) have revolutionized melanoma therapy. Still, the 5-year survival for advanced melanoma is only 50%. This leads to two questions: what makes some tumors less responsive to ICIs, and what can be done to increase resp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::092dbc736a180be8fc0e21ff2432fdcf
https://doi.org/10.1158/1538-7445.am2021-1577
https://doi.org/10.1158/1538-7445.am2021-1577