Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Katherine F. M. Jones"'
Autor:
Katherine F. M. Jones, Mohamed Shehata, Michael A. Carpenter, Rommie E. Amaro, Daniel A. Harki
Publikováno v:
ACS Medicinal Chemistry Letters. 14:338-343
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9227d70b7d5a316238389046c0dcceda
https://doi.org/10.1021/acsmedchemlett.2c00517
https://doi.org/10.1021/acsmedchemlett.2c00517
Autor:
Jian Tang, Ramkumar Moorthy, Özlem Demir, Zachary D. Baker, Jordan A. Naumann, Katherine F. M. Jones, Michael J. Grillo, Ella S. Haefner, Ke Shi, Michaella J Levy, Hideki Aihara, Reuben S. Harris, Rommie E. Amaro, Nicholas M. Levinson, Daniel A. Harki
Summary ParagraphMYCN amplification is the most frequent genetic driver in high-risk neuroblastoma (NB) and strongly associated with poor prognosis.1,2 The N-Myc transcription factor, which is encoded by MYCN, is a mechanistically validated, yet chal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c745273ce74fca7bc9488068f7950de4
https://doi.org/10.1101/2022.04.09.487756
https://doi.org/10.1101/2022.04.09.487756
Autor:
Matthew E. Cuellar, Daniel P Dempe, Kay M. Brummond, Paul A. Jackson, John C. Widen, Katherine F. M. Jones, Michael A. Walters, Henry A M Schares, Francois Grillet, Daniel A. Harki
Publikováno v:
J Med Chem
α-Methylene-γ-lactones are present in ∼3% of known natural products, and compounds comprising this motif display a range of biological activities. However, this reactive lactone limits informed structure-activity relationships for these bioactive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8068a1bbd168bb116fba4b4339fc5e39
https://doi.org/10.1021/acs.jmedchem.0c01464
https://doi.org/10.1021/acs.jmedchem.0c01464
Autor:
Daniel A. Harki, Fabien Emmetiere, Alexander J. Grenning, Emily Bevan–Smith, Hendrik Luesch, Henry A M Schares, Katherine F. M. Jones, Ranjala Ratnayake
Publikováno v:
Chemistry (Weinheim an der Bergstrasse, Germany). 27(17)
Described herein is a function-oriented synthesis route and biological evaluation of pseudoguaianolide analogues. The 10-step synthetic route developed retains the topological complexity of the natural product, installs functional handles for late-st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcae45dec7909a2c97eadb419e6c38b4
https://pubmed.ncbi.nlm.nih.gov/33502811
https://pubmed.ncbi.nlm.nih.gov/33502811