Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Katherine E. Chaney"'
Autor:
Robert A. Coover, Tabitha E. Healy, Li Guo, Katherine E. Chaney, Robert F. Hennigan, Craig S. Thomson, Lindsey E. Aschbacher-Smith, Michael P. Jankowski, Nancy Ratner
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-15 (2018)
Abstract Normal Schwann cells (SCs) are quiescent in adult nerves, when ATP is released from the nerve in an activity dependent manner. We find that suppressing nerve activity in adult nerves causes SC to enter the cell cycle. In vitro, ATP activates
Externí odkaz:
https://doaj.org/article/1bfa1d5d9ede4c02abd2406952f3a5c2
Autor:
Ami V. Patel, Katherine E. Chaney, Kwangmin Choi, David A. Largaespada, Ashish R. Kumar, Nancy Ratner
Publikováno v:
EBioMedicine, Vol 9, Iss C, Pp 110-119 (2016)
Malignant peripheral nerve sheath tumors (MPNST) are rare soft tissue sarcomas that are a major source of mortality in neurofibromatosis type 1 (NF1) patients. To identify MPNST driver genes, we performed a lentiviral short hairpin (sh) RNA screen, t
Externí odkaz:
https://doaj.org/article/d1d7aa60a45c42f880b7959e412461c3
Autor:
Nancy Ratner, David A. Largaespada, Sara Szabo, Eva Dombi, Tilat A. Rizvi, Kwangmin Choi, Jianqiang Wu, Ami V. Patel, Leah J. Kershner, Melissa R. Perrino, Katherine E. Chaney
Plexiform neurofibromas are benign nerve sheath Schwann cell tumors characterized by biallelic mutations in the neurofibromatosis type 1 (NF1) tumor suppressor gene. Atypical neurofibromas show additional frequent loss of CDKN2A/Ink4a/Arf and may be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::895cbfd788d6916740ef100c5a94f88c
https://doi.org/10.1158/0008-5472.c.6511891
https://doi.org/10.1158/0008-5472.c.6511891
Autor:
Nancy Ratner, David A. Largaespada, Sara Szabo, Eva Dombi, Tilat A. Rizvi, Kwangmin Choi, Jianqiang Wu, Ami V. Patel, Leah J. Kershner, Melissa R. Perrino, Katherine E. Chaney
Figure S1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ffe6d9e1d3b5decc78fb82ec32978e2
https://doi.org/10.1158/0008-5472.22424896
https://doi.org/10.1158/0008-5472.22424896
Autor:
Kwangmin Choi, Robert A. Coover, Nancy Ratner, Tilat A. Rizvi, Melissa R. Perrino, Katherine E. Chaney, Jay Pundavela, David A. Largaespada, Craig S. Thomson
Publikováno v:
Oncogene
Malignant peripheral nerve sheath tumors (MPNST) are aggressive soft-tissue sarcomas that cause significant mortality in adults with Neurofibromatosis Type 1 (NF1). We compared gene expression of growth factors in normal human nerves to MPNST and nor
Autor:
Steven P. Angus, Kwangmin Choi, Noah Sciaky, Katherine E. Chaney, Alexander Pemov, Florent Elefteriou, Andrea M. Gross, Jonathan J. Rios, Nancy Ratner, Steven D. Rhodes, Eva Dombi, Brigitte C. Widemann, D. Wade Clapp, Yun Ma
Publikováno v:
Genetics in medicine : official journal of the American College of Medical Genetics
Purpose Plexiform neurofibromas (NF) develop in children with Neurofibromatosis Type 1 (NF1) and can be associated with several skeletal co-morbidities. Preclinical mouse studies revealed Nf1 deficiency in osteoprogenitor cells disrupts, in a MEK-dep
Autor:
Jennifer Patritti Cram, Jianqiang Wu, Robert A Coover, Tilat A Rizvi, Katherine E Chaney, Ramya Ravindran, Jose A Cancelas, Robert J Spinner, Nancy Ratner
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1086bbc5c6891bffc248e8f3aec5f0ca
https://doi.org/10.7554/elife.73511.sa2
https://doi.org/10.7554/elife.73511.sa2
Autor:
Robert J. Spinner, Jennifer Patritti-Cram, Katherine E. Chaney, Shinji Kuninaka, Jose A. Cancelas, Jianqiang Wu, Robert F. Hennigan, Tilat A. Rizvi, Robert A. Coover, Ramya Ravindran, Nancy Ratner
Neurofibromatosis type 1 (NF1) is a genetic disorder characterized by nerve tumors called neurofibromas, in which Schwann cells (SCs) lack NF1 and show deregulated RAS signaling. NF1 is also implicated in regulation of cAMP. Gene expression profiling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ece2c5eedcfa53c2a480999cdb4b267
https://doi.org/10.1101/2021.09.24.461701
https://doi.org/10.1101/2021.09.24.461701
Autor:
Jennifer Patritti Cram, Jianqiang Wu, Robert A Coover, Tilat A Rizvi, Katherine E Chaney, Ramya Ravindran, Jose A Cancelas, Robert J Spinner, Nancy Ratner
Publikováno v:
eLife. 11
Neurofibromatosis type 1 (NF1) is characterized by nerve tumors called neurofibromas, in which Schwann cells (SCs) show deregulated RAS signaling. NF1 is also implicated in regulation of cAMP. We identified the G-protein-coupled receptor (GPCR) P2ry1
Autor:
Craig S. Thomson, Lindsey Aschbacher-Smith, Katherine E. Chaney, Michael P. Jankowski, Nancy Ratner, Li Guo, Robert A. Coover, Tabitha E. Healy, Robert F. Hennigan
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-15 (2018)
Acta Neuropathologica Communications
Acta Neuropathologica Communications
Normal Schwann cells (SCs) are quiescent in adult nerves, when ATP is released from the nerve in an activity dependent manner. We find that suppressing nerve activity in adult nerves causes SC to enter the cell cycle. In vitro, ATP activates the SC G