Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Katherine E. Brighty"'
Autor:
Steve Finegan, Jennifer L. Liras, John Schafer, Gregory G. Stone, Sarah K. Wade, Ann G. Connolly, Rhonda Monahan, Katherine E. Brighty, Joan Duignan, Steven J. Brickner, Phuong Le, Ivan J. Samardjiev, Richard P. Zaniewski, Dennis Girard, Jon Bordner, Meghan Maloney
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:276-279
SAR studies and optimization of various modified Hygromycin A fluoroalkyl ethers, which led to the discovery of the highly potent 4'-(2-cyclopropyl-2-fluoroethyl ether) antibacterial CE-156811 (1) derived from truncation of the ribose ring and difluo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d31058e211b4e5cd78b92b592ecef72f
https://doi.org/10.1016/j.bmcl.2010.11.022
https://doi.org/10.1016/j.bmcl.2010.11.022
Autor:
Kevin Daniel Freeman-Cook, Katherine E. Brighty, Phuong Le, Michael Scott Visser, Gary J. Martinelli, Sarah K. Wade, Steven J. Brickner, Dianna E. Moore, Rhonda Monahan, Kyle T. Blair
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:6730-6734
Novel hygromycin A derivatives bearing a variety of functionalized aminocyclitol moieties have been synthesized in an effort to increase the antibacterial activity and drug-like properties of this class of agents. A systematic study of the effect of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fd3fd9b256be349e2e6da8955d6667d
https://doi.org/10.1016/j.bmcl.2010.08.139
https://doi.org/10.1016/j.bmcl.2010.08.139
Publikováno v:
Antimicrobial Agents and Chemotherapy. 43:1783-1787
Eleven novel fluoroquinolones closely related to trovafloxacin were evaluated for their in vitro activity against Toxoplasma gondii , and their structure-activity relationships were examined. The 50% inhibitory concentration (IC 50 ) of trovafloxacin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::576cb15d63c18c3b2c13b8fa3af662c4
https://doi.org/10.1128/aac.43.7.1783
https://doi.org/10.1128/aac.43.7.1783
Autor:
Thomas D. Gootz, Katherine E. Brighty
Publikováno v:
Medicinal Research Reviews. 16:433-486
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3af835db11027df35f8fbc788bcd7deb
https://doi.org/10.1002/(sici)1098-1128(199609)16:5<433::aid-med3>3.0.co
https://doi.org/10.1002/(sici)1098-1128(199609)16:5<433::aid-med3>3.0.co
Publikováno v:
Synthetic Communications. 26:1423-1429
A convenient method for the synthesis of mono N-substituted guanylthioureas in reasonable yields from readily available starting materials has been developed. In contrast to the previously published method, the use of highly noxious hydrogen sulfide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb5207b5bd60d4b74be568cc17c878da
https://doi.org/10.1080/00397919608003504
https://doi.org/10.1080/00397919608003504
Autor:
Hardwin O'dowd, Katherine E. Brighty, Michael W. Fichtner, Donn G. Wishka, Goss S. Kauffman, Mark C. Noe, Marion Bédard, Jason G. Lewis, Richard A. Buzon, Brian Samas, Jaap Kooistra, Ivan J. Samardjiev, Kathleen A. Farley, Geeta Yalamanchi
Publikováno v:
The Journal of organic chemistry. 76(6)
To facilitate a drug discovery project, we needed to develop a robust asymmetric synthesis of (2S,5S)-5-substituted-azepane-2-carboxylate derivatives. Two key requirements for the synthesis were flexibility for elaboration at C5 and suitability for l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0679bee29b243873ab7356ff8fde330
https://pubmed.ncbi.nlm.nih.gov/21275376
https://pubmed.ncbi.nlm.nih.gov/21275376
Publikováno v:
ChemInform. 27
A convenient method for the synthesis of mono N-substituted guanylthioureas in reasonable yields from readily available starting materials has been developed. In contrast to the previously published method, the use of highly noxious hydrogen sulfide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::348839236b99fe2e56f7e30cb2cb9442
https://doi.org/10.1002/chin.199632049
https://doi.org/10.1002/chin.199632049
Autor:
Katherine E. Brighty, Thomas D. Gootz
Publikováno v:
ChemInform. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::14133007fd7c877ee2595a9e275cda8a
https://doi.org/10.1002/chin.199649316
https://doi.org/10.1002/chin.199649316
Publikováno v:
ChemInform. 28
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b03574ba3cf2c393539d348fc61ed914
https://doi.org/10.1002/chin.199715125
https://doi.org/10.1002/chin.199715125
Autor:
Katherine E. Brighty, Thomas D. Gootz
Publisher Summary Quinolone agents exhibit a bicyclic aromatic core, containing a carbon at the 8th position, yielding a true quinolone, or a nitrogen, and provide a ring system technically termed as naphthyridone. In common usage, both quinolone and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35106f9e44b6110126b41c50d2aa7ac2
https://doi.org/10.1016/b978-012059517-4/50003-9
https://doi.org/10.1016/b978-012059517-4/50003-9
