Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Katherine E. Brighty"'
Autor:
Steve Finegan, Jennifer L. Liras, John Schafer, Gregory G. Stone, Sarah K. Wade, Ann G. Connolly, Rhonda Monahan, Katherine E. Brighty, Joan Duignan, Steven J. Brickner, Phuong Le, Ivan J. Samardjiev, Richard P. Zaniewski, Dennis Girard, Jon Bordner, Meghan Maloney
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:276-279
SAR studies and optimization of various modified Hygromycin A fluoroalkyl ethers, which led to the discovery of the highly potent 4'-(2-cyclopropyl-2-fluoroethyl ether) antibacterial CE-156811 (1) derived from truncation of the ribose ring and difluo
Autor:
Kevin Daniel Freeman-Cook, Katherine E. Brighty, Phuong Le, Michael Scott Visser, Gary J. Martinelli, Sarah K. Wade, Steven J. Brickner, Dianna E. Moore, Rhonda Monahan, Kyle T. Blair
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:6730-6734
Novel hygromycin A derivatives bearing a variety of functionalized aminocyclitol moieties have been synthesized in an effort to increase the antibacterial activity and drug-like properties of this class of agents. A systematic study of the effect of
Publikováno v:
Antimicrobial Agents and Chemotherapy. 43:1783-1787
Eleven novel fluoroquinolones closely related to trovafloxacin were evaluated for their in vitro activity against Toxoplasma gondii , and their structure-activity relationships were examined. The 50% inhibitory concentration (IC 50 ) of trovafloxacin
Autor:
Thomas D. Gootz, Katherine E. Brighty
Publikováno v:
Medicinal Research Reviews. 16:433-486
Publikováno v:
Synthetic Communications. 26:1423-1429
A convenient method for the synthesis of mono N-substituted guanylthioureas in reasonable yields from readily available starting materials has been developed. In contrast to the previously published method, the use of highly noxious hydrogen sulfide
Autor:
Hardwin O'dowd, Katherine E. Brighty, Michael W. Fichtner, Donn G. Wishka, Goss S. Kauffman, Mark C. Noe, Marion Bédard, Jason G. Lewis, Richard A. Buzon, Brian Samas, Jaap Kooistra, Ivan J. Samardjiev, Kathleen A. Farley, Geeta Yalamanchi
Publikováno v:
The Journal of organic chemistry. 76(6)
To facilitate a drug discovery project, we needed to develop a robust asymmetric synthesis of (2S,5S)-5-substituted-azepane-2-carboxylate derivatives. Two key requirements for the synthesis were flexibility for elaboration at C5 and suitability for l
Publikováno v:
ChemInform. 27
A convenient method for the synthesis of mono N-substituted guanylthioureas in reasonable yields from readily available starting materials has been developed. In contrast to the previously published method, the use of highly noxious hydrogen sulfide
Autor:
Katherine E. Brighty, Thomas D. Gootz
Publikováno v:
ChemInform. 27
Publikováno v:
ChemInform. 28
Autor:
Katherine E. Brighty, Thomas D. Gootz
Publisher Summary Quinolone agents exhibit a bicyclic aromatic core, containing a carbon at the 8th position, yielding a true quinolone, or a nitrogen, and provide a ring system technically termed as naphthyridone. In common usage, both quinolone and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35106f9e44b6110126b41c50d2aa7ac2
https://doi.org/10.1016/b978-012059517-4/50003-9
https://doi.org/10.1016/b978-012059517-4/50003-9