Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Katherine E Varley"'
Autor:
Tian-Yeh Lim, Blake R Wilde, Mallory L Thomas, Kristin E Murphy, Jeffery M Vahrenkamp, Megan E Conway, Katherine E Varley, Jason Gertz, Donald E Ayer
Publikováno v:
PLoS Biology, Vol 21, Iss 3, p e3001778 (2023)
The c-Myc protooncogene places a demand on glucose uptake to drive glucose-dependent biosynthetic pathways. To meet this demand, c-Myc protein (Myc henceforth) drives the expression of glucose transporters, glycolytic enzymes, and represses the expre
Externí odkaz:
https://doaj.org/article/7572474847da4aaf9911a7ea46d99e21
Autor:
Amelia D Wallace, Thomas A Sasani, Jordan Swanier, Brooke L Gates, Jeff Greenland, Brent S Pedersen, Katherine E Varley, Aaron R Quinlan
Publikováno v:
PLoS ONE, Vol 16, Iss 4, p e0241253 (2021)
A substantial fraction of the human genome is difficult to interrogate with short-read DNA sequencing technologies due to paralogy, complex haplotype structures, or tandem repeats. Long-read sequencing technologies, such as Oxford Nanopore's MinION,
Externí odkaz:
https://doaj.org/article/b40febd6e2ea4665b168e7184b3bf972
Autor:
Katelyn L. Mortenson, Courtney Dawes, Emily R. Wilson, Nathan E. Patchen, Hailey E. Johnson, Jason Gertz, Swneke D. Bailey, Yang Liu, Katherine E. Varley, Xiaoyang Zhang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Cancer genomes are composed of many complex structural alterations on chromosomes and extrachromosomal DNA (ecDNA), making it difficult to identify non-coding enhancer regions that are hijacked to activate oncogene expression. Here, we descr
Externí odkaz:
https://doaj.org/article/d6062aefe62a4d37bf53dab9508d3937
Autor:
Jason Gertz, Katherine E Varley, Timothy E Reddy, Kevin M Bowling, Florencia Pauli, Stephanie L Parker, Katerina S Kucera, Huntington F Willard, Richard M Myers
Publikováno v:
PLoS Genetics, Vol 7, Iss 8, p e1002228 (2011)
The methylation of cytosines in CpG dinucleotides is essential for cellular differentiation and the progression of many cancers, and it plays an important role in gametic imprinting. To assess variation and inheritance of genome-wide patterns of DNA
Externí odkaz:
https://doaj.org/article/2abfdcce32734e878176e8e269a24ef1
Autor:
Katherine E. Varley, Albert F. LoBuglio, Richard M. Myers, Donald J. Buchsbaum, Christos Vaklavas, Todd C. Burwell, Erinn Downs-Kelly, Natalie D. Merz, Katherine L. Updike, William E. Grizzle, Dongquan Chen, Yufeng Li, Andres Forero
This file contains: Supplementary Methods for Tissue Processing, RNA-seq, RNA-seq analysis, and Immunohistochemistry. Supplementary Figure 1: Overlap between clusters identified in our data and TNBC subtypes described in previous studies. Supplementa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fc0ebc556aafb5e0bffd7f3a5ecaae1
https://doi.org/10.1158/2326-6066.22537210.v1
https://doi.org/10.1158/2326-6066.22537210.v1
Autor:
Katherine E. Varley, Albert F. LoBuglio, Richard M. Myers, Donald J. Buchsbaum, Christos Vaklavas, Todd C. Burwell, Erinn Downs-Kelly, Natalie D. Merz, Katherine L. Updike, William E. Grizzle, Dongquan Chen, Yufeng Li, Andres Forero
Triple-negative breast cancer (TNBC) is a subtype with heterogeneous patient outcomes. Approximately 40% of patients experience rapid relapse, while the remaining patients have long-term disease-free survival. To determine if there are molecular diff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c3047575fc84af0f45c1779f997f467
https://doi.org/10.1158/2326-6066.c.6548350.v1
https://doi.org/10.1158/2326-6066.c.6548350.v1
Autor:
Antonio C. Wolff, Richard M. Myers, William Grizzle, Paul Haluska, Jennifer F. De Los Santos, Helen Krontiras, William J. Irvin, Julie R. Nangia, Catherine H. Van Poznak, Sujata Patil, Tiffany A. Traina, Anna M. Storniolo, Rita Nanda, Hope S. Rugo, Minetta C. Liu, Nancy U. Lin, Christos Vaklavas, Yufeng Li, Vandana G. Abramson, Katherine E. Varley, Andres Forero-Torres
Purpose: Tigatuzumab (TIG), an agonistic anti-DR5 antibody, triggers apoptosis in DR5+ human tumor cells without crosslinking. TIG has strong in vitro/in vivo activity against basal-like breast cancer cells enhanced by chemotherapy agents. This study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01aeb05ea0f9b666431db03db47907f2
https://doi.org/10.1158/1078-0432.c.6524804.v1
https://doi.org/10.1158/1078-0432.c.6524804.v1
Autor:
Katherine E. Varley, Philip S. Bernard, Kenneth M. Boucher, N. Lynn Henry, Rachel E. Factor, Katherine L. Updike, Rachel L. Stewart
Supplemental Figures 1-7 include a graphical outline of the study, graphs depicting probe performance, correlations between MHCII and TIL scores, ROC statistics, and additional Kaplan Meier curves.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36c8e00e3b8380faa5139aaf60688a25
https://doi.org/10.1158/0008-5472.22421493
https://doi.org/10.1158/0008-5472.22421493
Autor:
Antonio C. Wolff, Richard M. Myers, William Grizzle, Paul Haluska, Jennifer F. De Los Santos, Helen Krontiras, William J. Irvin, Julie R. Nangia, Catherine H. Van Poznak, Sujata Patil, Tiffany A. Traina, Anna M. Storniolo, Rita Nanda, Hope S. Rugo, Minetta C. Liu, Nancy U. Lin, Christos Vaklavas, Yufeng Li, Vandana G. Abramson, Katherine E. Varley, Andres Forero-Torres
1. Supplemental Data: Differential of Toxicity and Eligibility Critique.; 2. Supplemental Figure 1: Gene Expression in Patients With Response to Therapy.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c77e2fd7a84def7242af058231a6b81
https://doi.org/10.1158/1078-0432.22461524.v1
https://doi.org/10.1158/1078-0432.22461524.v1
Autor:
Katherine E. Varley, Philip S. Bernard, Kenneth M. Boucher, N. Lynn Henry, Rachel E. Factor, Katherine L. Updike, Rachel L. Stewart
Approximately 40% of patients with stage I–III triple-negative breast cancer (TNBC) recur after standard treatment, whereas the remaining 60% experience long-term disease-free survival (DFS). There are currently no clinical tests to assess the risk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a8c2cf7c38e219f174f566e798e48c0
https://doi.org/10.1158/0008-5472.c.6510948
https://doi.org/10.1158/0008-5472.c.6510948