Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Katherine E Varley"'
Autor:
Katelyn L. Mortenson, Courtney Dawes, Emily R. Wilson, Nathan E. Patchen, Hailey E. Johnson, Jason Gertz, Swneke D. Bailey, Yang Liu, Katherine E. Varley, Xiaoyang Zhang
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Cancer genomes are composed of many complex structural alterations on chromosomes and extrachromosomal DNA (ecDNA), making it difficult to identify non-coding enhancer regions that are hijacked to activate oncogene expression. Here, we descr
Externí odkaz:
https://doaj.org/article/d6062aefe62a4d37bf53dab9508d3937
Autor:
Tian-Yeh Lim, Blake R Wilde, Mallory L Thomas, Kristin E Murphy, Jeffery M Vahrenkamp, Megan E Conway, Katherine E Varley, Jason Gertz, Donald E Ayer
Publikováno v:
PLoS Biology, Vol 21, Iss 3, p e3001778 (2023)
The c-Myc protooncogene places a demand on glucose uptake to drive glucose-dependent biosynthetic pathways. To meet this demand, c-Myc protein (Myc henceforth) drives the expression of glucose transporters, glycolytic enzymes, and represses the expre
Externí odkaz:
https://doaj.org/article/7572474847da4aaf9911a7ea46d99e21
Autor:
Yanli Liu, Zhong Wu, Jin Zhou, Dinesh K. A. Ramadurai, Katelyn L. Mortenson, Estrella Aguilera-Jimenez, Yifei Yan, Xiaojun Yang, Alison M. Taylor, Katherine E. Varley, Jason Gertz, Peter S. Choi, Andrew D. Cherniack, Xingdong Chen, Adam J. Bass, Swneke D. Bailey, Xiaoyang Zhang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
SOX2 amplification and overexpression represents a hallmark of squamous cancers with distinct distribution of chromatin accessible regions depending on cancer type. Here, the authors identify a single enhancer e1 that predominantly drives SOX2 expres
Externí odkaz:
https://doaj.org/article/e4b25bd5f49a4f25aa65202beead9236
Autor:
Mayra A. Gonzalez, Idaly M. Olivas, Alfonso E. Bencomo‐Alvarez, Andres J. Rubio, Christian Barreto‐Vargas, Jose L. Lopez, Sara K. Dang, Jonathan P. Solecki, Emily McCall, Gonzalo Astudillo, Vanessa V. Velazquez, Katherine Schenkel, Kelaiah Reffell, Mariah Perkins, Nhu Nguyen, Jehu N. Apaflo, Efren Alvidrez, James E. Young, Joshua J. Lara, Dongqing Yan, Anna Senina, Jonathan Ahmann, Katherine E. Varley, Clinton C. Mason, Christopher A. Eide, Brian J. Druker, Md Nurunnabi, Osvaldo Padilla, Sudip Bajpeyi, Anna M. Eiring
Publikováno v:
Clinical and Translational Medicine, Vol 12, Iss 12, Pp n/a-n/a (2022)
Abstract Tyrosine kinase inhibitors (TKIs) targeting BCR::ABL1 have turned chronic myeloid leukaemia (CML) from a fatal disease into a manageable condition for most patients. Despite improved survival, targeting drug‐resistant leukaemia stem cells
Externí odkaz:
https://doaj.org/article/0d778c96fbce4f62a37c6a5e642b07ee
Autor:
Christos Vaklavas, Brian S. Roberts, Katherine E. Varley, Nancy U. Lin, Minetta C. Liu, Hope S. Rugo, Shannon Puhalla, Rita Nanda, Anna Maria Storniolo, Lisa A. Carey, Mansoor N. Saleh, Yufeng Li, Jennifer F. Delossantos, William E. Grizzle, Albert F. LoBuglio, Richard M. Myers, Andres Forero-Torres, on behalf of the Translational Breast Cancer Research Consortium (TBCRC)
Publikováno v:
Breast Cancer Research, Vol 22, Iss 1, Pp 1-15 (2020)
Abstract Background In preclinical studies, the expression of vascular endothelial growth factor (VEGF) in hormone receptor-positive breast cancer is associated with estrogen-independent tumor growth and resistance to endocrine therapies. This study
Externí odkaz:
https://doaj.org/article/5584ed790988432a9d02c709cacd449f
Autor:
Amelia D Wallace, Thomas A Sasani, Jordan Swanier, Brooke L Gates, Jeff Greenland, Brent S Pedersen, Katherine E Varley, Aaron R Quinlan
Publikováno v:
PLoS ONE, Vol 16, Iss 4, p e0241253 (2021)
A substantial fraction of the human genome is difficult to interrogate with short-read DNA sequencing technologies due to paralogy, complex haplotype structures, or tandem repeats. Long-read sequencing technologies, such as Oxford Nanopore's MinION,
Externí odkaz:
https://doaj.org/article/b40febd6e2ea4665b168e7184b3bf972
Autor:
Katherine E. Varley, Albert F. LoBuglio, Richard M. Myers, Donald J. Buchsbaum, Christos Vaklavas, Todd C. Burwell, Erinn Downs-Kelly, Natalie D. Merz, Katherine L. Updike, William E. Grizzle, Dongquan Chen, Yufeng Li, Andres Forero
This file contains: Supplementary Methods for Tissue Processing, RNA-seq, RNA-seq analysis, and Immunohistochemistry. Supplementary Figure 1: Overlap between clusters identified in our data and TNBC subtypes described in previous studies. Supplementa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fc0ebc556aafb5e0bffd7f3a5ecaae1
https://doi.org/10.1158/2326-6066.22537210.v1
https://doi.org/10.1158/2326-6066.22537210.v1
Autor:
Katherine E. Varley, Albert F. LoBuglio, Richard M. Myers, Donald J. Buchsbaum, Christos Vaklavas, Todd C. Burwell, Erinn Downs-Kelly, Natalie D. Merz, Katherine L. Updike, William E. Grizzle, Dongquan Chen, Yufeng Li, Andres Forero
Triple-negative breast cancer (TNBC) is a subtype with heterogeneous patient outcomes. Approximately 40% of patients experience rapid relapse, while the remaining patients have long-term disease-free survival. To determine if there are molecular diff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c3047575fc84af0f45c1779f997f467
https://doi.org/10.1158/2326-6066.c.6548350.v1
https://doi.org/10.1158/2326-6066.c.6548350.v1
Autor:
Antonio C. Wolff, Richard M. Myers, William Grizzle, Paul Haluska, Jennifer F. De Los Santos, Helen Krontiras, William J. Irvin, Julie R. Nangia, Catherine H. Van Poznak, Sujata Patil, Tiffany A. Traina, Anna M. Storniolo, Rita Nanda, Hope S. Rugo, Minetta C. Liu, Nancy U. Lin, Christos Vaklavas, Yufeng Li, Vandana G. Abramson, Katherine E. Varley, Andres Forero-Torres
Purpose: Tigatuzumab (TIG), an agonistic anti-DR5 antibody, triggers apoptosis in DR5+ human tumor cells without crosslinking. TIG has strong in vitro/in vivo activity against basal-like breast cancer cells enhanced by chemotherapy agents. This study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01aeb05ea0f9b666431db03db47907f2
https://doi.org/10.1158/1078-0432.c.6524804.v1
https://doi.org/10.1158/1078-0432.c.6524804.v1
Autor:
Katherine E. Varley, Philip S. Bernard, Kenneth M. Boucher, N. Lynn Henry, Rachel E. Factor, Katherine L. Updike, Rachel L. Stewart
Supplemental Figures 1-7 include a graphical outline of the study, graphs depicting probe performance, correlations between MHCII and TIL scores, ROC statistics, and additional Kaplan Meier curves.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36c8e00e3b8380faa5139aaf60688a25
https://doi.org/10.1158/0008-5472.22421493
https://doi.org/10.1158/0008-5472.22421493