Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Katherine E Simon"'
Autor:
Alejandra Mondino, Chin-Chieh Yang, Katherine E Simon, Gilad Fefer, James Robertson, Margaret E Gruen, Natasha J Olby
Publikováno v:
PLoS ONE, Vol 19, Iss 9, p e0301181 (2024)
Advancements in veterinary medicine have resulted in increased life spans for dogs, necessitating a better understanding of quality of life for older dogs. This study aimed to evaluate quality of life (QoL) progression and its potential association w
Externí odkaz:
https://doaj.org/article/6963d076ea6149b48a2cc6c4796816f9
Autor:
Trevor J. Gonzalez, Katherine E. Simon, Leo O. Blondel, Marco M. Fanous, Angela L. Roger, Maribel Santiago Maysonet, Garth W. Devlin, Timothy J. Smith, Daniel K. Oh, L. Patrick Havlik, Ruth M. Castellanos Rivera, Jorge A. Piedrahita, Mai K. ElMallah, Charles A. Gersbach, Aravind Asokan
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Abstract Recombinant adeno-associated viral (AAV) vectors are a promising gene delivery platform, but ongoing clinical trials continue to highlight a relatively narrow therapeutic window. Effective clinical translation is confounded, at least in part
Externí odkaz:
https://doaj.org/article/d9d15ee20e5e46a9b86982294d7e7093
Autor:
Rita M. Meganck, Jiacheng Liu, Andrew E. Hale, Katherine E. Simon, Marco M. Fanous, Heather A. Vincent, Jeremy E. Wilusz, Nathaniel J. Moorman, William F. Marzluff, Aravind Asokan
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 23, Iss , Pp 821-834 (2021)
Circular RNAs (circRNAs) are highly stable RNA molecules that are attractive templates for expression of therapeutic proteins and non-coding RNAs. In eukaryotes, circRNAs are primarily generated by the spliceosome through backsplicing. Here, we inter
Externí odkaz:
https://doaj.org/article/010d4637b6644616b9a2c316a95f48a2
Publikováno v:
JCI Insight, Vol 5, Iss 19 (2020)
Preexisting humoral immunity to recombinant adeno-associated virus (AAV) vectors restricts the treatable patient population and efficacy of human gene therapies. Approaches to clear neutralizing antibodies (NAbs), such as plasmapheresis and immunosup
Externí odkaz:
https://doaj.org/article/d725ad0f77e647e98dea71ee5d4a0903
Autor:
Andrew E. Hale, Katherine E. Simon, William F. Marzluff, Rita M. Meganck, Jeremy E. Wilusz, Jiacheng Liu, Nathaniel J. Moorman, Aravind Asokan, Heather A. Vincent, Marco M. Fanous
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 23, Iss, Pp 821-834 (2021)
Molecular Therapy. Nucleic Acids
Molecular Therapy. Nucleic Acids
Circular RNAs (circRNAs) are highly stable RNA molecules that are attractive templates for expression of therapeutic proteins and non-coding RNAs. In eukaryotes, circRNAs are primarily generated by the spliceosome through backsplicing. Here, we inter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d39cea54c678256b7578d7a49d26b5f
http://www.sciencedirect.com/science/article/pii/S2162253121000032
http://www.sciencedirect.com/science/article/pii/S2162253121000032
Publikováno v:
JCI Insight, Vol 5, Iss 19 (2020)
JCI Insight
JCI Insight
Preexisting humoral immunity to recombinant adeno-associated virus (AAV) vectors restricts the treatable patient population and efficacy of human gene therapies. Approaches to clear neutralizing antibodies (NAbs), such as plasmapheresis and immunosup
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f3c0aa86f8a354d8ddf3ee11594b861
https://doi.org/10.1172/jci.insight.139881
https://doi.org/10.1172/jci.insight.139881
Autor:
Mario Mietzsch, Aravind Asokan, L. Patrick Havlik, Kelli A. Klinc, Jürgen A. Kleinschmidt, Mavis Agbandje-McKenna, Marco M. Fanous, Daniel K. Oh, J. Kennon Smith, Katherine E. Simon, Rita M. Meganck, Longping V. Tse
Publikováno v:
Journal of Virology
Clinical gene therapy with recombinant AAV vectors has largely relied on natural capsid isolates. There is an unmet need to comprehensively improve AAV tissue tropism, transduction efficiency, and antibody evasion. Such cannot be achieved by utilizin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74ddb3bd1fc1dfa33d32c5961ddee6cf
https://pubmed.ncbi.nlm.nih.gov/32669336
https://pubmed.ncbi.nlm.nih.gov/32669336
Pre-existing humoral immunity to recombinant adeno-associated viral (AAV) vectors restricts the treatable patient population and efficacy of human gene therapies. Approaches to clear neutralizing antibodies (NAbs), such as plasmapheresis and immunosu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fcd2f60be61b98cbc8e7fe19798ad284
https://doi.org/10.1101/2020.05.12.092122
https://doi.org/10.1101/2020.05.12.092122
Publikováno v:
Journal of Virology. 93
Central nervous system (CNS) transduction by systemically administered recombinant adeno-associated viral (AAV) vectors requires crossing the blood-brain barrier (BBB). We recently mapped a structural footprint on the AAVrh.10 capsid, which, when gra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3ab7420706cf72c984b113c6cadd7fd
https://doi.org/10.1128/jvi.00332-19
https://doi.org/10.1128/jvi.00332-19
Publikováno v:
Brain Research. 1231:75-80
Heavy fetal alcohol exposure is associated with a spectrum of neurological abnormalities, although the mechanism of injury is largely unknown. We previously reported attenuated cerebral blood flow response to hypoxia in fetal and newborn sheep which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f3bf612246f42685f529c33881b06dd
https://doi.org/10.1016/j.brainres.2008.06.125
https://doi.org/10.1016/j.brainres.2008.06.125