Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Katherine E Pinnick"'
Autor:
Matt J Neville, Laura B L Wittemans, Katherine E Pinnick, Marijana Todorčević, Risto Kaksonen, Kirsi H Pietiläinen, Jian'an Luan, Robert A Scott, Nicholas J Wareham, Claudia Langenberg, Fredrik Karpe
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0217644 (2019)
Waist-to-hip ratio (WHR) is a prominent cardiometabolic risk factor that increases cardio-metabolic disease risk independently of BMI and for which multiple genetic loci have been identified. However, WHR is a relatively crude proxy for fat distribut
Externí odkaz:
https://doaj.org/article/cb3253c1f5514e3cbcc7bc7e9ee85dba
Autor:
Jonathan M. Gamwell, Keanu Paphiti, Leanne Hodson, Fredrik Karpe, Katherine E. Pinnick, Marijana Todorčević
Publikováno v:
Adipocyte, Vol 12, Iss 1 (2023)
ABSTRACTWhile there is no standardized protocol for the differentiation of human adipocytes in culture, common themes exist in the use of supra-physiological glucose and hormone concentrations, and an absence of exogenous fatty acids. These factors c
Externí odkaz:
https://doaj.org/article/a0868e8681f54d6fa6f2031e1944b8e6
Autor:
Catriona Hilton, Matt J. Neville, Laura B.L. Wittemans, Marijana Todorcevic, Katherine E. Pinnick, Sara L. Pulit, Jian'an Luan, Agné Kulyté, Ingrid Dahlman, Nicholas J. Wareham, Luca A. Lotta, Peter Arner, Cecilia M. Lindgren, Claudia Langenberg, Fredrik Karpe
Publikováno v:
EBioMedicine, Vol 44, Iss , Pp 467-475 (2019)
Background: Abdominal fat mass is associated with metabolic risk whilst gluteal femoral fat is paradoxically protective. MicroRNAs are known to be necessary for adipose tissue formation and function but their role in regulating human fat distribution
Externí odkaz:
https://doaj.org/article/132352bcea1b412e8fe99d6280bbbd8f
Autor:
Pippa J. Gunn, Camilla Pramfalk, Val Millar, Thomas Cornfield, Matthew Hutchinson, Elspeth M. Johnson, Shilpa R. Nagarajan, Perla Troncoso‐Rey, Richard F. Mithen, Katherine E. Pinnick, Maria H. Traka, Charlotte J. Green, Leanne Hodson
Publikováno v:
Physiological Reports, Vol 8, Iss 13, Pp n/a-n/a (2020)
Abstract Background and Aims Nonalcoholic fatty liver disease (NAFLD) begins with steatosis, where a mixed macrovesicular pattern of large and small lipid droplets (LDs) develops. Since in vitro models recapitulating this are limited, the aims of thi
Externí odkaz:
https://doaj.org/article/e32076d2d1cd413e9564f974e3446efb
Publikováno v:
Molecular Metabolism, Vol 16, Iss , Pp 172-179 (2018)
Objective: The composition of the extracellular matrix (ECM) impacts adipocyte function and might determine adipose tissue (AT) function and distribution. Cartilage oligomeric matrix protein (COMP), a matricellular protein usually studied in bone and
Externí odkaz:
https://doaj.org/article/dd560fff29d344f2931e52c26b9b117b
Autor:
Karim Bensaad, Elena Favaro, Caroline A. Lewis, Barrie Peck, Simon Lord, Jennifer M. Collins, Katherine E. Pinnick, Simon Wigfield, Francesca M. Buffa, Ji-Liang Li, Qifeng Zhang, Michael J.O. Wakelam, Fredrik Karpe, Almut Schulze, Adrian L. Harris
Publikováno v:
Cell Reports, Vol 9, Iss 1, Pp 349-365 (2014)
Summary: An in vivo model of antiangiogenic therapy allowed us to identify genes upregulated by bevacizumab treatment, including Fatty Acid Binding Protein 3 (FABP3) and FABP7, both of which are involved in fatty acid uptake. In vitro, both were indu
Externí odkaz:
https://doaj.org/article/e1e264078b5c49b6b6c2525e5f12d70f
Autor:
Charlotte J Green, Thomas Marjot, John Walsby-Tickle, Catriona Charlton, Thomas Cornfield, Felix Westcott, Katherine E Pinnick, Ahmad Moolla, Jonathan M Hazlehurst, James McCullagh, Jeremy W Tomlinson, Leanne Hodson
Objective Metformin is a first-line pharmacotherapy in the treatment of type 2 diabetes, a condition closely associated with non-alcoholic fatty liver disease (NAFLD). Although metformin promotes weight loss and improves insulin sensitivity, its effe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e4ae4874c6c19249dd759fceb7e3d27
https://doi.org/10.1530/eje-21-0850
https://doi.org/10.1530/eje-21-0850
Extracellular vesicles (EVs) are lipid enclosed envelopes that carry biologically active material such as proteins, RNA, metabolites and lipids. EVs can modulate the cellular status of other cells locally in tissue microenvironments or through libera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee7f67825edf87d0faf92b038e5450ad
https://doi.org/10.1101/2020.12.03.20243089
https://doi.org/10.1101/2020.12.03.20243089
Autor:
Elspeth M. Johnson, Richard Mithen, Charlotte J. Green, Leanne Hodson, Thomas Cornfield, Katherine E. Pinnick, Matthew Hutchinson, Pippa J. Gunn, Shilpa R. Nagarajan, Val Millar, Camilla Pramfalk, Maria Traka, Perla Troncoso-Rey
Publikováno v:
Physiological Reports, Vol 8, Iss 13, Pp n/a-n/a (2020)
Physiological Reports
Physiological Reports
Background and Aims Nonalcoholic fatty liver disease (NAFLD) begins with steatosis, where a mixed macrovesicular pattern of large and small lipid droplets (LDs) develops. Since in vitro models recapitulating this are limited, the aims of this study w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d20507e27ff9a7c61f828cc56475aa6
https://doi.org/10.14814/phy2.14482
https://doi.org/10.14814/phy2.14482
Autor:
James E.N. Minchin, John F. Rawls, Julia El Sayed Moustafa, Nathan Denton, Fredrik Karpe, Marijana Todorčević, Constantinos Christodoulides, John P. Kemp, Nellie Y. Loh, David M. Evans, Anubha Mahajan, Mark I. McCarthy, Manu Verma, Celia L Gregson, Matt J. Neville, Kerrin S. Small, Katherine E. Pinnick
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Loh, N Y, Minchin, J E N, Pinnick, K E, Verma, M, Todorčević, M, Denton, N, El-Sayed Moustafa, J, P. Kemp, J, Gregson, C L, Evans, D M, Neville, M J, Small, K S, McCarthy, M I, Mahajan, A, Rawls, J F, Karpe, F & Christodoulides, C 2020, ' RSPO3 impacts body fat distribution and regulates adipose cell biology in vitro ', Nature Communications, vol. 11, 2797 . https://doi.org/10.1038/s41467-020-16592-z
Loh, N Y, Minchin, JE, Pinnick, K E, Verma, M, Todorčević, M, Denton, N, El-Sayed Moustafa, J S, Kemp, J P, Gregson, C L, Evans, D, Neville, M J, Small, K S, McCarthy, M I, Mahajan, A, Rawls, J F, Karpe, F & Christodoulides, C 2020, ' RSPO3 impacts body fat distribution and regulates adipose cell biology in vitro ', Nature Communications, vol. (2020) 11, 2797 . https://doi.org/10.1038/s41467-020-16592-z
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Loh, N Y, Minchin, J E N, Pinnick, K E, Verma, M, Todorčević, M, Denton, N, El-Sayed Moustafa, J, P. Kemp, J, Gregson, C L, Evans, D M, Neville, M J, Small, K S, McCarthy, M I, Mahajan, A, Rawls, J F, Karpe, F & Christodoulides, C 2020, ' RSPO3 impacts body fat distribution and regulates adipose cell biology in vitro ', Nature Communications, vol. 11, 2797 . https://doi.org/10.1038/s41467-020-16592-z
Loh, N Y, Minchin, JE, Pinnick, K E, Verma, M, Todorčević, M, Denton, N, El-Sayed Moustafa, J S, Kemp, J P, Gregson, C L, Evans, D, Neville, M J, Small, K S, McCarthy, M I, Mahajan, A, Rawls, J F, Karpe, F & Christodoulides, C 2020, ' RSPO3 impacts body fat distribution and regulates adipose cell biology in vitro ', Nature Communications, vol. (2020) 11, 2797 . https://doi.org/10.1038/s41467-020-16592-z
Fat distribution is an independent cardiometabolic risk factor. However, its molecular and cellular underpinnings remain obscure. Here we demonstrate that two independent GWAS signals at RSPO3, which are associated with increased body mass index-adju
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d6f2bebf972c47cc7176712a31a5b32
https://ora.ox.ac.uk/objects/uuid:6cb86e0f-cc0e-4bf5-86d7-da85300193e1
https://ora.ox.ac.uk/objects/uuid:6cb86e0f-cc0e-4bf5-86d7-da85300193e1