Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Katherine E, Lewis"'
Autor:
Amanda Enstrom, Elizabeth Repash, Ismail Simsek, Stanford L Peng, Katherine E Lewis, Zahra Maria, Tiffany C Blair, Lawrence S Evans, Armand Bankhead, Stacey R Dillon
Publikováno v:
Lupus Science and Medicine, Vol 11, Iss Suppl 1 (2024)
Externí odkaz:
https://doaj.org/article/5ed55ccf4699457486577b4085658d84
Autor:
Mark F. Maurer, Katherine E. Lewis, Joseph L. Kuijper, Dan Ardourel, Chelsea J. Gudgeon, Siddarth Chandrasekaran, Sherri L. Mudri, Kayla N. Kleist, Chris Navas, Martin F. Wolfson, Mark W. Rixon, Ryan Swanson, Stacey R. Dillon, Steven D. Levin, Yengo Raymond Kimbung, Masato Akutsu, Derek T. Logan, Björn Walse, Kristine M. Swiderek, Stanford L. Peng
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
CD28 costimulatory signalling can be suppressed by immune checkpoints, such as CTLA-4 and PD-1. Here the authors describe the design of the fusion therapeutic davoceticept (ALPN-202), based on a variant CD80 extracellular domain engineered to bind PD
Externí odkaz:
https://doaj.org/article/1c1e0e459c4147429eef80ef95841f04
Autor:
Steven D. Levin, Lawrence S. Evans, Susan Bort, Erika Rickel, Katherine E. Lewis, Rebecca P. Wu, Joseph Hoover, Sean MacNeil, David La, Martin F. Wolfson, Mark W. Rixon, Stacey R. Dillon, Michael G. Kornacker, Ryan Swanson, Stanford L. Peng
Publikováno v:
Frontiers in Immunology, Vol 10 (2020)
Immunoglobulin superfamily member (IgSF) proteins play a significant role in regulating immune responses with surface expression on all immune cell subsets, making the IgSF an attractive family of proteins for therapeutic targeting in human diseases.
Externí odkaz:
https://doaj.org/article/bed901c0bf43422ba8dc0a6914b60717
Autor:
Tommaso Iannitti, Joseph M. Scarrott, Shibi Likhite, Ian R.P. Coldicott, Katherine E. Lewis, Paul R. Heath, Adrian Higginbottom, Monika A. Myszczynska, Marta Milo, Guillaume M. Hautbergue, Kathrin Meyer, Brian K. Kaspar, Laura Ferraiuolo, Pamela J. Shaw, Mimoun Azzouz
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 12, Iss , Pp 75-88 (2018)
Of familial amyotrophic lateral sclerosis (fALS) cases, 20% are caused by mutations in the gene encoding human cytosolic Cu/Zn superoxide dismutase (hSOD1). Efficient translation of the therapeutic potential of RNAi for the treatment of SOD1-ALS pati
Externí odkaz:
https://doaj.org/article/b30506436b9849bf842271b7ed602925
Autor:
Stacey R. Dillon, Lawrence S. Evans, Katherine E. Lewis, Susan Debrot, Tiffany C. Blair, Sherri Mudri, Kayla Kleist, Steven D. Levin, Janhavi G. Bhandari, Logan Garrett, Martin F. Wolfson, Pamela M. Holland, Mark W. Rixon, Stanford L. Peng
Publikováno v:
Arthritis & Rheumatology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8bed8247443c2f4840d627abb9e8554f
https://doi.org/10.1002/art.42484
https://doi.org/10.1002/art.42484
Autor:
Lawrence S. Evans, Katherine E. Lewis, Daniel DeMonte, Janhavi G. Bhandari, Logan B. Garrett, Joseph L. Kuijper, Daniel Ardourel, Martin F. Wolfson, Susan Debrot, Sherri Mudri, Kayla Kleist, Luana L. Griffin, LuAnne Hebb, Russell J. Sanderson, NingXin Wang, Michelle Seaberg, Allison G. Chunyk, Jing Yang, Youji Hong, Zahra Maria, David J. Messenheimer, Pamela M. Holland, Stanford L. Peng, Mark W. Rixon, Stacey R. Dillon
Publikováno v:
Arthritis & Rheumatology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ceb1c0338d138b60d4b730dd88a1296e
https://doi.org/10.1002/art.42462
https://doi.org/10.1002/art.42462
Autor:
Katherine E. Lewis, Mark J. Selby, Gregg Masters, Jose Valle, Gennaro Dito, Wendy R. Curtis, Richard Garcia, Kathy A. Mink, Kimberly S. Waggie, Matthew S. Holdren, Joseph F. Grosso, Alan J. Korman, Maria Jure-Kunkel, Stacey R. Dillon
Publikováno v:
OncoImmunology, Vol 7, Iss 1 (2018)
Recent advances in cancer treatment with checkpoint blockade of receptors such as CTLA-4 and PD-1 have demonstrated that combinations of agents with complementary immunomodulatory effects have the potential to enhance antitumor activity as compared t
Externí odkaz:
https://doaj.org/article/54e3b8070e6e4ea1b4254c709405e4a3
Autor:
Catherine A. Blizzard, Katherine A. Southam, Edgar Dawkins, Katherine E. Lewis, Anna E. King, Jayden A. Clark, Tracey C. Dickson
Publikováno v:
Disease Models & Mechanisms, Vol 8, Iss 3, Pp 215-224 (2015)
There is a desperate need for targeted therapeutic interventions that slow the progression of amyotrophic lateral sclerosis (ALS). ALS is a disorder with heterogeneous onset, which then leads to common final pathways involving multiple neuronal compa
Externí odkaz:
https://doaj.org/article/f0fdcd3ed3b842c586a30e775dcb3170
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 3, Iss C (2016)
Current barriers to the use of adeno-associated virus serotype 9 (AAV9) in clinical trials for treating neurological disorders are its high expression in many off-target tissues such as liver and heart, and lack of cell specificity within the central
Externí odkaz:
https://doaj.org/article/277aebb8e4f840fda98da39b9a8b4cff
Autor:
Laura A Reale, Marcus S Dyer, Tracey C. Dickson, Catherine A. Blizzard, Katherine E. Lewis, Adele Woodhouse, Adam K. Walker
Publikováno v:
Journal of Neurochemistry. 157:1300-1315
Amyotrophic lateral sclerosis (ALS) is a chronic neurodegenerative disease pathologically characterised by mislocalisation of the RNA-binding protein TAR-DNA-binding protein 43 (TDP-43) from the nucleus to the cytoplasm. Changes to neuronal excitabil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce2318bcdeef41b91f98a707c6cff9c3
https://doi.org/10.1111/jnc.15214
https://doi.org/10.1111/jnc.15214