Výsledky vyhledávání - "Katherine Doores"

The impact of Spike mutations on SARS-CoV-2 neutralization

Multiple SARS-CoV-2 vaccines have shown protective efficacy, which is most likely mediated by neutralizing antibodies recognizing the viral entry protein, Spike. Antibodies from SARS-CoV-2 infection neutralize the virus by focused targeting of Spike

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::332089f00f4f253a66d1bd77f1f52f5b
https://doi.org/10.1101/2021.01.15.426849

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The polybasic cleavage site in the SARS-CoV-2 spike modulates viral sensitivity to Type I IFN and IFITM2

Autor: Helena Winstone, Suzanne Pickering, Chad M. Swanson, Katherine Doores, Stuart J. D. Neil, M. J. Lista Brotos, A. Reid

The cellular entry of severe acute respiratory syndrome-associated coronaviruses types 1 and 2 (SARS-CoV-1 and -2) requires sequential protease processing of the viral spike glycoprotein (S). The presence of a polybasic cleavage site in SARS-CoV-2 S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c694874334b3b2f8219cc9ff9a70dbeb
https://doi.org/10.1101/2020.12.19.423592

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Protein and glycan mimicry in HIV vaccine design

Autor: Max Crispin, Gemma E. Seabright, Katherine Doores, Dennis R. Burton

Publikováno v: Journal of Molecular Biology
Seabright, G E, Doores, K J, Burton, D R & Crispin, M 2019, ' Protein and glycan mimicry in HIV vaccine design ', Journal of Molecular Biology, vol. 431, no. 12, https://doi.org/10.1016/j.jmb.2019.04.016, pp. 2223-2247 . https://doi.org/10.1016/j.jmb.2019.04.016

Antigenic mimicry is a fundamental tenet of structure-based vaccinology. Vaccine strategies for the human immunodeficiency virus type 1 (HIV-1) focus on the mimicry of its envelope spike (Env) due to its exposed location on the viral membrane and rol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::191832897ade7cd61f4361effe2a54f6
https://eprints.soton.ac.uk/430318/

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B Cells from Knock-in Mice Expressing Broadly Neutralizing HIV Antibody b12 Carry an Innocuous B Cell Receptor Responsive to HIV Vaccine Candidates

Autor: Anthony B. Cooper, David Nemazee, Katherine Doores, William R. Schief, Khoa Le, Miyo Aoki-Ota, Colleen Doyle-Cooper, Richard T. Wyatt, Takayuki Ota, Dennis R. Burton

Publikováno v: The Journal of Immunology. 191:3179-3185

Broadly neutralizing Abs against HIV protect from infection, but their routine elicitation by vaccination has not been achieved. To generate small animal models to test vaccine candidates, we have generated targeted transgenic (“knock-in”) mice e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::274a1280c29a4c41cf3b3816aade278c
https://doi.org/10.4049/jimmunol.1301283

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2G12-Expressing B Cell Lines May Aid in HIV Carbohydrate Vaccine Design Strategies

Autor: Khoa Le, Ralph Pantophlet, Anthony B. Cooper, Michael Huber, Dennis R. Burton, David Nemazee, Chi-Huey Wong, Colleen Doyle-Cooper, Katherine Doores, Sheng-Kai Wang

Publikováno v: Journal of Virology. 87:2234-2241

The highly conserved cluster of high-mannose glycans on the HIV-1 envelope glycoprotein, gp120, has been highlighted as a target for neutralizing antibodies. 2G12, the first HIV-1 antiglycan neutralizing antibody described, binds with an unusual doma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89c286fce78af47a3bd7a255b97d8bfd
https://doi.org/10.1128/jvi.02820-12

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A nonself sugar mimic of the HIV glycan shield shows enhanced antigenicity

Autor: Benjamin G. Davis, M. G. Finn, Dennis R. Burton, Ian A. Wilson, Vu Hong, Mark R. Wormald, Mitul Patel, Zara Fulton, Katherine Doores, Christopher N. Scanlan

Antibody 2G12 uniquely neutralizes a broad range of HIV-1 isolates by binding the high-mannose glycans on the HIV-1 surface glycoprotein, gp120. Antigens that resemble these natural epitopes of 2G12 would be highly desirable components for an HIV-1 v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f52500f7faa5118d8942379e48401a80
https://ora.ox.ac.uk/objects/uuid:e6e5b533-9754-4201-8a48-d740abc65d09

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The glycan shield of HIV is predominantly oligomannose independently of production system or viral clade

Autor: Camille Bonomelli, Victoria E. Thaney, Christopher N. Scanlan, Katherine Doores, Dennis R. Burton, D. Cameron Dunlop, Max Crispin, Raymond A. Dwek

Publikováno v: PLoS ONE, Vol 6, Iss 8, p e23521 (2011)
PLoS ONE

The N-linked oligomannose glycans of HIV gp120 are a target for both microbicide and vaccine design. The extent of cross-clade conservation of HIV oligomannose glycans is therefore a critical consideration for the development of HIV prophylaxes. We m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3faccf198f35d89230ce3f0225135229
https://doi.org/10.1371/journal.pone.0023521

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Atomic-scale detection of organic molecules coupled to single-walled carbon nanotubes

Autor: Gerard Tobias, Katherine Doores, Angus I. Kirkland, Malcolm L. H. Green, Sung You Hong, Belén Ballesteros, Farid El Oualid, Peter D. Nellist, Benjamin G. Davis, James C. Errey

Single-walled carbon nanotubes (SWNTs) functionalized with organic molecules bearing high-scattering element tags have allowed direct visualization of modification on the atomic scale. The inclusion of these tags in protecting groups allowed their su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ff8c0632f95d70d0a1b4f754708459f
https://doi.org/10.1021/ja069080i

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Antibody 2G12 Recognizes Di-Mannose Equivalently in Domain- and Nondomain-Exchanged Forms but Only Binds the HIV-1 Glycan Shield if Domain Exchanged

Autor: Katherine Doores, Michael Huber, Zara Fulton, Dennis R. Burton, Ian A. Wilson

Publikováno v: Journal of Virology. 84:10690-10699

The broadly neutralizing anti-human immunodeficiency virus type 1 (HIV-1) antibody 2G12 targets the high-mannose cluster on the glycan shield of HIV-1. 2G12 has a unique V H domain-exchanged structure, with a multivalent binding surface that includes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00392072ac3aadc8ac2d11f135d85be2
https://doi.org/10.1128/jvi.01110-10

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Variable Loop Glycan Dependency of the Broad and Potent HIV-1-Neutralizing Antibodies PG9 and PG16

Autor: Dennis R. Burton, Katherine Doores

Publikováno v: Journal of Virology. 84:10510-10521

The HIV-1-specific antibodies PG9 and PG16 show marked cross-isolate neutralization breadth and potency. Antibody neutralization has been shown to be dependent on the presence of N-linked glycosylation at position 160 in gp120. We show here that (i)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6ebb2d38f0135a623e540d56a6224b6
https://doi.org/10.1128/jvi.00552-10

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