Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Katherine D. Barclay"'
Publikováno v:
Microcirculation. 7:335-346
Objective:To determine whether red cell movement, as measured by laser Doppler velocimetry, in the capillary net of the beating heart is chaotic. Methods:Using two dog hearts, in situred blood cell flux was measured at many sites. Simultaneously, epi
Autor:
Susan J. Buckley, Gerald A. Klassen, P. T. Pollak, J. D. Feng, Pollen K.F. Yeung, Orlando Hung, Katherine D. Barclay
Publikováno v:
Therapeutic Drug Monitoring. 19:286-291
To determine the clinical effect of diltiazem on the metabolism of adenosine, and its importance in ischemic heart disease, arterial plasma concentrations of the purine metabolites were determined in 21 healthy volunteers (10 female and 11 male) and
Autor:
Gerald A. Klassen, Bernard Perey, Barry E. Paton, Allan S. MacDonald, David T. Janigan, Katherine D. Barclay, John Mathews
Publikováno v:
Obesity Research. 4:145-151
Objective: To measure red cell flux of adipose tissue in morbidly obese patients' pannus in the upright and supine position to determine factors which would render the lower pannus susceptible to ischemic necrosis. Design: A cohort study of morbidly
Autor:
Katherine D. Barclay, Susan J. Buckley, Gerald A. Klassen, Pollen F. K. Yeung, P. Timothy Pollak, Orlando Hung
Publikováno v:
The Journal of Clinical Pharmacology. 35:1144-1149
This preliminary phase I study was conducted in healthy volunteers to determine whether gender differences exist in the hemodynamic effects of diltiazem at rest, during exercise, and after exercise. At comparable serum concentrations of the drug, wom
Publikováno v:
Cancer Treatment Reviews. 19:299-349
Despite intensive investigation of hyperbaric oxygen, hypoxic cell sensitizers and hyperthermia, these modalities have had little impact on clinical outcome. Recently, new strategies to improve cancer control using existing therapeutic agents have be
Publikováno v:
Cardiovascular research. 34(3)
Objective: (1) To measure regional phasic myocardial red cell flux during a cardiac cycle using a laser Doppler velocimeter. (2) To test the responses of regional red cell flux to a vasodilator (adenosine), a vasoconstrictor (angiotensin II), and an
Autor:
Orlando Hung, Katherine D. Barclay, Susan J. Buckley, Gerald A. Klassen, Patrick S. Farmer, P. T. Pollak, Pollen K.F. Yeung, Joe Feng
Publikováno v:
Therapeutic drug monitoring. 18(1)
Diltiazem (DTZ) is a calcium antagonist widely used in the treatment of angina and hypertension. It is extensively metabolized in humans via N-demethylation, O-demethylation, deacetylation, and oxidative deamination, yielding a host of metabolites, s
Publikováno v:
Lipids. 29(12)
Free fatty acids accumulate in plant membranes after exposure of plants to environmental stress, such as freezing and desiccation. Fatty acid accumulation has been linked to various biophysical changes and to the occurrence of lipid peroxidation, but