Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Katherine C. Murphy"'
Autor:
Maša Alečković, Simona Cristea, Carlos R. Gil Del Alcazar, Pengze Yan, Lina Ding, Ethan D. Krop, Nicholas W. Harper, Ernesto Rojas Jimenez, Donghao Lu, Anushree C. Gulvady, Pierre Foidart, Marco Seehawer, Benedetto Diciaccio, Katherine C. Murphy, Jason Pyrdol, Jayati Anand, Kodie Garza, Kai W. Wucherpfennig, Rulla M. Tamimi, Franziska Michor, Kornelia Polyak
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
TGFβ signalling is reported to regulate hormone-responsive mammary epithelial progenitors that are associated with breast cancer risk. Here, the authors find that short-term TGFBR1 inhibition prevents tumour formation in rat breast cancer models and
Externí odkaz:
https://doaj.org/article/1cad67a83e124a70947f561786bfe0e4
Autor:
Michalina Janiszewska, Shayna Stein, Otto Metzger Filho, Jennifer Eng, Natalie L. Kingston, Nicholas W. Harper, Inga H. Rye, Maša Alečković, Anne Trinh, Katherine C. Murphy, Elisabetta Marangoni, Simona Cristea, Benjamin Oakes, Eric P. Winer, Ian E. Krop, Hege G. Russnes, Paul T. Spellman, Elmar Bucher, Zhi Hu, Koei Chin, Joe W. Gray, Franziska Michor, Kornelia Polyak
Publikováno v:
JCI Insight, Vol 6, Iss 11 (2021)
Despite the availability of multiple human epidermal growth factor receptor 2–targeted (HER2-targeted) treatments, therapeutic resistance in HER2+ breast cancer remains a clinical challenge. Intratumor heterogeneity for HER2 and resistance-conferri
Externí odkaz:
https://doaj.org/article/ced21837b6ad4073a0511b1ee2946f97
Autor:
Loretah Chibaya, Katherine C. Murphy, Kelly D. DeMarco, Sneha Gopalan, Haibo Liu, Chaitanya N. Parikh, Yvette Lopez-Diaz, Melissa Faulkner, Junhui Li, John P. Morris, Yu-jui Ho, Sachliv K. Chana, Janelle Simon, Wei Luan, Amanda Kulick, Elisa de Stanchina, Karl Simin, Lihua Julie Zhu, Thomas G. Fazzio, Scott W. Lowe, Marcus Ruscetti
Publikováno v:
Nature Cancer.
Autor:
Kornelia Polyak, Senthil K. Muthuswamy, Deborah A. Dillon, Gordon J. Freeman, Sara M. Tolaney, Eliezer M. Van Allen, Tanya E. Keenan, Katherine C. Murphy, Bethlehem Lulseged, Ethan D. Krop, Shanshan Xie, Michael U.J. Oliphant, Nicholas W. Harper, Ernesto Rojas Jimenez, Maša Alečković, Anne Trinh, Carlos R. Gil Del Alcazar
Supplementary Figure from Insights into Immune Escape During Tumor Evolution and Response to Immunotherapy Using a Rat Model of Breast Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b3e63f003b1e1eafb910ef2ba844d94
https://doi.org/10.1158/2326-6066.22544781
https://doi.org/10.1158/2326-6066.22544781
Autor:
Kornelia Polyak, Senthil K. Muthuswamy, Deborah A. Dillon, Gordon J. Freeman, Sara M. Tolaney, Eliezer M. Van Allen, Tanya E. Keenan, Katherine C. Murphy, Bethlehem Lulseged, Ethan D. Krop, Shanshan Xie, Michael U.J. Oliphant, Nicholas W. Harper, Ernesto Rojas Jimenez, Maša Alečković, Anne Trinh, Carlos R. Gil Del Alcazar
Animal models are critical for the preclinical validation of cancer immunotherapies. Unfortunately, mouse breast cancer models do not faithfully reproduce the molecular subtypes and immune environment of the human disease. In particular, there are no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c53be361367e588cf66a62c9dd98b28
https://doi.org/10.1158/2326-6066.c.6550743
https://doi.org/10.1158/2326-6066.c.6550743
Autor:
Kornelia Polyak, Senthil K. Muthuswamy, Deborah A. Dillon, Gordon J. Freeman, Sara M. Tolaney, Eliezer M. Van Allen, Tanya E. Keenan, Katherine C. Murphy, Bethlehem Lulseged, Ethan D. Krop, Shanshan Xie, Michael U.J. Oliphant, Nicholas W. Harper, Ernesto Rojas Jimenez, Maša Alečković, Anne Trinh, Carlos R. Gil Del Alcazar
Supplementary Table from Insights into Immune Escape During Tumor Evolution and Response to Immunotherapy Using a Rat Model of Breast Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13c9b07e181291f79292007acc15d6e1
https://doi.org/10.1158/2326-6066.22544772.v1
https://doi.org/10.1158/2326-6066.22544772.v1
Autor:
Loretah Chibaya, Katherine C. Murphy, Yvette Lopez-Diaz, Kelly D. DeMarco, Haibo Liu, Sneha Gopalan, Melissa Faulkner, Junhui Li, John P. Morris, Yu-jui Ho, Janelle Simon, Wei Luan, Amanda Kulick, Elisa de Stanchina, Karl Simin, Lihua Julie Zhu, Thomas G. Fazzio, Scott W. Lowe, Marcus Ruscetti
T cell-activating immunotherapies that produce durable and even curative responses in some malignancies have failed in pancreatic ductal adenocarcinoma (PDAC) due to rampant immune suppression and poor tumor immunogenicity. We and others have demonst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::570739343b1e0e49ab96836332f5e641
https://doi.org/10.1101/2022.06.21.495523
https://doi.org/10.1101/2022.06.21.495523
Autor:
Carlos R. Gil Del Alcazar, Anne Trinh, Maša Alečković, Ernesto Rojas Jimenez, Nicholas W. Harper, Michael U.J. Oliphant, Shanshan Xie, Ethan D. Krop, Bethlehem Lulseged, Katherine C. Murphy, Tanya E. Keenan, Eliezer M. Van Allen, Sara M. Tolaney, Gordon J. Freeman, Deborah A. Dillon, Senthil K. Muthuswamy, Kornelia Polyak
Publikováno v:
Cancer Immunol Res
Animal models are critical for the preclinical validation of cancer immunotherapies. Unfortunately, mouse breast cancer models do not faithfully reproduce the molecular subtypes and immune environment of the human disease. In particular, there are no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8831c6269935f7802d25316936319a86
https://europepmc.org/articles/PMC9177779/
https://europepmc.org/articles/PMC9177779/
Autor:
Janelle Simon, Elisa de Stanchina, Lihua Julie Zhu, Haibo Liu, Scott W. Lowe, John P. Morris, Yvette Lopez-Diaz, Loretah Chibaya, Katherine C. Murphy, Marcus Ruscetti, Lakhena Leang, Wei Luan, Amanda Kulick, Yu-Jui Ho
Publikováno v:
Cancer Research. 81:PO-124
T cell-targeting immunotherapies that produce durable and sometimes curative responses in other malignancies have failed in pancreatic ductal adenocarcinoma (PDAC) due to poor T cell infiltration and tumor immunogenicity. We and others have demonstra