Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Katherine C. M. Chew"'
Publikováno v:
Neuroscience. 496:205-218
Tone-evoked synaptic excitation and inhibition are highly correlated in many neurons with V-shaped tuning curves in the primary auditory cortex of pentobarbital-anesthetized rats. In contrast, there is less correlation between spontaneous excitation
Autor:
Grace G Y Lim, Katherine C M Chew, Xiao-Hui Ng, Adeline Henry-Basil, Roy W X Sim, Jeanne M M Tan, Chou Chai, Kah-Leong Lim
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e73235 (2013)
Disruption of the ubiquitin-proteasome system, which normally identifies and degrades unwanted intracellular proteins, is thought to underlie neurodegeneration. Supporting this, mutations of Parkin, a ubiquitin ligase, are associated with autosomal r
Externí odkaz:
https://doaj.org/article/341b4e7893d44f2b828ee8f7401a706c
Autor:
Katherine C. M. Chew, Chou Chai, Byorn W.L. Tan, Chao Liu, Han-Ming Shen, Ping Liao, Cheng Yang Ng, Sreedharan Sajikumar, Y. L. Lam, Bryce W.Q. Tan, Steven Yuan, Mui Cheng Liang, Tuck Wah Soong, Sheeja Navakkode, Shi Yin, Esther Wong, Sijie Tan, Yee Kit Tai, Kah-Leong Lim
Mammalian Target of Rapamycin (mTOR) is a master regulator of autophagy and lysosomes, and its downstream kinase-dependent pathways have been extensively characterized. Here, we report an unexpected kinase-independent regulation of autophagy and lyso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07d48768b77111b5ade0e8725e745b15
https://doi.org/10.1101/2020.09.11.292607
https://doi.org/10.1101/2020.09.11.292607
Autor:
Katherine C. M. Chew, Seok Ting Ang, Sanjay Khanna, Bryce W.Q. Tan, Fai Tsang, Chao Liu, Chengwu Zhang, Bobby Tan, Mui Cheng Liang, Dejie Yu, Hwee Tong Tan, Tuck Wah Soong, John Jia En Chua, Yee Kit Tai, Bing Han Chai, Shun Qiang Lo, Jia Ying Tang, Kah-Leong Lim, Mitchell K.P. Lai, Maxey C. M. Chung
Publikováno v:
J Neurosci
Elevated iron deposition has been reported in Parkinson's disease (PD). However, the route of iron uptake leading to high deposition in the substantia nigra is unresolved. Here, we show a mechanism in enhanced Fe2+uptake via S-nitrosylation of divale
Autor:
Katherine C M Chew, Noriyuki Matsuda, Keiko Saisho, Grace G Y Lim, Chou Chai, Hui-Mei Tan, Keiji Tanaka, Kah-Leong Lim
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e19720 (2011)
Mutations in the parkin gene, which encodes a ubiquitin ligase (E3), are a major cause of autosomal recessive parkinsonism. Although parkin-mediated ubiquitination was initially linked to protein degradation, accumulating evidence suggests that the e
Externí odkaz:
https://doaj.org/article/4987a5e223204bd09706a72f5e91c936
Autor:
Qingshu Lin, Sabrina Jia Ning Tay, Katherine C. M. Chew, Tuck Wah Soong, Thomas Behnisch, Sheeja Navakkode
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Scientific Reports
Scientific Reports
Long-term potentiation (LTP) is the persistent increase in the strength of the synapses. However, the neural networks would become saturated if there is only synaptic strenghthening. Synaptic weakening could be facilitated by active processes like lo
Autor:
Fai Tsang, Katherine C. M. Chew, Yee Kit Tai, Tuck Wah Soong, Eugenia T. E. Hong, Kah-Leong Lim, A.B.M.A. Asad, Kai-Hsiang Chuang, Eng-Tat Ang, Bryce W.Q. Tan, Bing Han Chai, Chengwu Zhang
Publikováno v:
Neuromolecular Medicine
Exposure to divalent metals such as iron and manganese is thought to increase the risk for Parkinson’s disease (PD). Under normal circumstances, cellular iron and manganese uptake is regulated by the divalent metal transporter 1 (DMT1). Accordingly
Publikováno v:
Scientific Reports
Manganese (Mn2+) neurotoxicity from occupational exposure is well documented to result in a Parkinson-like syndrome. Although the understanding of Mn2+ cytotoxicity is still incomplete, both Mn2+ and Fe2+ can be transported via the divalent metal tra
Autor:
Han-Ming Shen, Kah-Leong Lim, Wei-Yi Ong, Fai Tsang, Tuck Wah Soong, Valina L. Dawson, Shun Qiang Lo, Eng Tat Ang, Katherine C. M. Chew, Yee Kit Tai, Elijah Ong, Ted M. Dawson
Publikováno v:
Journal of Biological Chemistry. 286:33380-33389
Parkinson disease (PD), a prevalent neurodegenerative motor disorder, is characterized by the rather selective loss of dopaminergic neurons and the presence of α-synuclein-enriched Lewy body inclusions in the substantia nigra of the midbrain. Althou
Autor:
Shiam Peng Tay, Cheng Wang, Bobby Thomas, Han Seok Ko, Fai Tsang, Katherine C. M. Chew, Michelle W L Ho, Juan C. Troncoso, Tit Meng Lim, Ted M. Dawson, Olga Pletnikova, Tuck Wah Soong, Kah-Leong Lim, Valina L. Dawson
Publikováno v:
Human Molecular Genetics. 14:3885-3897
Mutations in parkin are currently recognized as the most common cause of familial Parkinsonism. Emerging evidence also suggests that parkin expression variability may confer a risk for the development of the more common, sporadic form of Parkinson's