Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Katherine C. Fein"'
Long‐term daily oral administration of intestinal permeation enhancers is safe and effective in mice
Autor:
Katherine C. Fein, John P. Gleeson, Kyle Cochran, Nicholas G. Lamson, Rose Doerfler, Jilian R. Melamed, Kathryn A. Whitehead
Publikováno v:
Bioengineering & Translational Medicine, Vol 8, Iss 1, Pp n/a-n/a (2023)
Abstract Although protein drugs are powerful biologic therapeutics, they cannot be delivered orally because their large size and hydrophilicity limit their absorption across the intestinal epithelium. One potential solution is the incorporation of pe
Externí odkaz:
https://doaj.org/article/85b4c567bc5744c5b8b5653f55eff395
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 170:70-76
The decades-long effort to deliver peptide drugs orally has resulted in several clinically successful formulations. These formulations are enabled by the inclusion of permeation enhancers that facilitate the intestinal absorption of peptides. Thus fa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0784034748cf7102fbbb598dc05c22aa
https://doi.org/10.1016/j.ejpb.2021.11.010
https://doi.org/10.1016/j.ejpb.2021.11.010
Autor:
John P. Gleeson, Namit Chaudhary, Katherine C. Fein, Rose Doerfler, Patricia Hredzak-Showalter, Kathryn A. Whitehead
Publikováno v:
Science advances. 8(26)
Breast milk is chock-full of nutrients, immunological factors, and cells that aid infant development. Maternal cells are the least studied breast milk component, and their unique properties are difficult to identify using traditional techniques. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::119c9ac1e3c33f0800076b35d74cce49
https://pubmed.ncbi.nlm.nih.gov/35767604
https://pubmed.ncbi.nlm.nih.gov/35767604
Long‐term daily oral administration of intestinal permeation enhancers is safe and effective in mice
Autor:
Katherine C. Fein, John P. Gleeson, Kyle Cochran, Nicholas G. Lamson, Rose Doerfler, Jilian R. Melamed, Kathryn A. Whitehead
Publikováno v:
Bioengineering & Translational Medicine. 8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5de1924f4bd4bf541acfc1c41c44c34c
https://doi.org/10.1002/btm2.10342
https://doi.org/10.1002/btm2.10342
Autor:
Katherine C. Fein, Shiyuan Zheng, Kathryn A. Whitehead, Nicholas G. Lamson, Kris Noel Dahl, Kirill Lavrenyuk
Publikováno v:
ACS Biomaterials Science & Engineering. 6:367-374
A major obstacle for topical and enteral drug delivery is the poor transport of macromolecular drugs through the epithelium. One potential solution is the use of permeation enhancers that alter epithelial structures. Piperazine derivatives are known
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82f4ccd2b81d1ca88d3db587a7587f78
https://doi.org/10.1021/acsbiomaterials.9b01660
https://doi.org/10.1021/acsbiomaterials.9b01660
Autor:
Kathryn A. Whitehead, Trish Hredzak-Showalter, Katherine C. Fein, Namit Chaudhary, Rose Doerfler, John P. Gleeson
Breastmilk is chock-full of nutrients, immunological factors, and cells that aid infant development. Maternal cells are the least studied breastmilk component, and their unique properties are difficult to identify using traditional techniques. Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::948fbbb33233fda97d22b7983a8cb44d
https://doi.org/10.1101/2021.10.04.463125
https://doi.org/10.1101/2021.10.04.463125
Publikováno v:
Nature Biomedical Engineering. 4:84-96
The oral delivery of bioactive peptides and proteins is prevented by the intestinal epithelial barrier, in which intercellular tight junction complexes block the uptake of macromolecules. Here we show that anionic nanoparticles induce tight junction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0fe5fab2c042e28a10f4fd97991b1f52
https://doi.org/10.1038/s41551-019-0465-5
https://doi.org/10.1038/s41551-019-0465-5
Publikováno v:
Adv Drug Deliv Rev
The vast majority of drugs are not designed or developed for pediatric and infant populations. Peptide drugs, which have become increasingly relevant in the past several decades, are no exception. Unfortunately, nearly all of the 60+ approved peptide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fae217136894b1bdfa998e674341b0cd
https://pubmed.ncbi.nlm.nih.gov/33774115
https://pubmed.ncbi.nlm.nih.gov/33774115
Autor:
Rose Doerfler, Alexandra N. Newby, Katherine C. Fein, John P. Gleeson, Kathryn A. Whitehead, Namit Chaudhary
Publikováno v:
Int J Pharm
Oral delivery of macromolecular drugs is the most patient-preferred route of administration because it is painless and convenient. Over the past 30 years, significant attention has been paid to oral protein delivery in adults. Unfortunately, there is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bec371676c1af1112ad41d89bd375dde
https://pubmed.ncbi.nlm.nih.gov/33249250
https://pubmed.ncbi.nlm.nih.gov/33249250
Autor:
Alexandra N. Newby, Katherine C. Fein, Ahuja, Kolodieznyi D, Xian S, Kathryn A. Whitehead, Rebecca L. Ball, Zhang A, Berger A, Brigitte F. Schmidt, John P. Gleeson, Nicholas G. Lamson, Melamed, Silva Gl, Namit Chaudhary, Kanika Suri, Cochran K
Although oral drug delivery is preferred by patients, it is not possible for proteins because the gastrointestinal tract is not sufficiently permeable. To enable the non-toxic oral uptake of protein drugs, we investigated plant-based foods as intesti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29f50fc3ca49eb64bd226f07bfc41e42
https://doi.org/10.1101/2020.03.11.987461
https://doi.org/10.1101/2020.03.11.987461