Výsledky vyhledávání - "Katherine Bowlin"

Akademický článek

Centromere-independent accumulation of cohesin at ectopic heterochromatin sites induces chromosome stretching during anaphase.

Autor: Raquel A Oliveira, Shaila Kotadia, Alexandra Tavares, Mihailo Mirkovic, Katherine Bowlin, Christian S Eichinger, Kim Nasmyth, William Sullivan

Publikováno v: PLoS Biology, Vol 12, Iss 10, p e1001962 (2014)

Pericentric heterochromatin, while often considered as "junk" DNA, plays important functions in chromosome biology. It contributes to sister chromatid cohesion, a process mediated by the cohesin complex that ensures proper genome segregation during n

Externí odkaz: https://doaj.org/article/6ed1730047c04b4cb8bfbb71518cdc21

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Heterochromatic breaks move to the nuclear periphery to continue recombinational repair

Autor: Katherine Bowlin, Laetitia Delabaere, Gary H. Karpen, Hannah Hopp, Irene Chiolo, Taehyun Ryu, Ryan Kunitake, Brett N. Spatola

Publikováno v: Nature cell biology

Heterochromatin mostly comprises repeated sequences prone to harmful ectopic recombination during double-strand break (DSB) repair. In Drosophila cells, 'safe' homologous recombination (HR) repair of heterochromatic breaks relies on a specialized pat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dbb93200bba84f4fff177e90e4fde87
https://doi.org/10.1038/ncb3258

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Centromere-independent accumulation of cohesin at ectopic heterochromatin sites induces chromosome stretching during anaphase

Autor: Mihailo Mirkovic, Katherine Bowlin, Alexandra Tavares, William J. Sullivan, Shaila Kotadia, Christian S. Eichinger, Raquel A. Oliveira, Kim Nasmyth

Publikováno v: PLoS Biology, Vol 12, Iss 10, p e1001962 (2014)
PLoS Biology
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

Live imaging of cells carrying rearranged chromosomes shows that misplaced heterochromatin is sufficient to induce ectopic cohesion and chromosome stretching during mitosis, and may compromise genetic stability.
Pericentric heterochromatin, whil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18601af4635cb0c552b8ab9e10d9e8ab
http://europepmc.org/articles/PMC4188515?pdf=render

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