Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Katherine Bourne"'
Autor:
Imogen Moran, Akira Nguyen, Weng Hua Khoo, Danyal Butt, Katherine Bourne, Clara Young, Jana R. Hermes, Maté Biro, Gary Gracie, Cindy S. Ma, C. Mee Ling Munier, Fabio Luciani, John Zaunders, Andrew Parker, Anthony D. Kelleher, Stuart G. Tangye, Peter I. Croucher, Robert Brink, Mark N. Read, Tri Giang Phan
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Memory B cells need to be reactivated to produce high affinity antibody responses on subsequent antigen encounters. Here the authors show that memory B cells localise to lymph node subcapsular proliferative foci (SPF), which have distinct properties
Externí odkaz:
https://doaj.org/article/434c7143b0dc490799e9dd7d746d107f
Autor:
Christopher, Sundling, Angelica W Y, Lau, Katherine, Bourne, Clara, Young, Candy, Laurianto, Jana R, Hermes, Rosemary J, Menzies, Danyal, Butt, Nike J, Kräutler, David, Zahra, Dan, Suan, Robert, Brink
Publikováno v:
Immunity. 54(5)
Positive selection of high-affinity B cells within germinal centers (GCs) drives affinity maturation of antibody responses. Here, we examined the mechanism underlying the parallel transition from immunoglobulin M (IgM) to IgG. Early GCs contained mos
Autor:
Robert Brink, Christopher C. Goodnow, Daniel Christ, Katherine Bourne, David B. Langley, Ashley M. Buckle, Deborah L. Burnett, Peter R. Schofield, Benjamin T. Porebski, Emily Wilson, Jennifer Jackson
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Conformational diversity of foreign antigens and cross-reactivity with self are implicated in the failure to generate effective antibody responses against many challenging pathogens, but few studies directly address how these two factors
Autor:
Ervin E. Kara, Dimitra Zotos, Katherine Bourne, David M. Tarlinton, Duncan R. McKenzie, Cameron R. Bastow, Geoffrey R. Hill, Shaun R. McColl, Jason G. Cyster, Robert Brink, Kevin A. Fenix, Derek S. Gilchrist, Rachelle Babb, Iain Comerford, Jana R. Hermes, Carly E. Gregor, Todd Norton, Carola G. Vinuesa, Robert J. B. Nibbs, Mohammed Alsharifi, Lauren B. Rodda
Publikováno v:
The Journal of Experimental Medicine
The Journal of experimental medicine, vol 215, iss 3
The Journal of experimental medicine, vol 215, iss 3
Kara et al. show that ACKR4 regulates early activated B cell differentiation fate. ACKR4 limits the early proliferation of activated B cells by restricting their initial access to the splenic interfollicular zone.
Activated B cells can initially
Activated B cells can initially
Autor:
Katherine Bourne, Robert Brink, Angelica W.Y. Lau, David Zahra, Nike Julia Krautler, Candy Laurianto, Jana R. Hermes, Clara Young, Danyal Butt, Dan Suan, Rosemary J. Menzies, Christopher Sundling
Publikováno v:
Immunity. 54:988-1001.e5
Summary Positive selection of high-affinity B cells within germinal centers (GCs) drives affinity maturation of antibody responses. Here, we examined the mechanism underlying the parallel transition from immunoglobulin M (IgM) to IgG. Early GCs conta
Autor:
Robert Brink, Charles R. Mackay, Di Yu, Jian Tan, Louis M. Tsai, Katherine Bourne, Alison N. Thorburn, Remy Robert, Linda J. Mason, Nina Chevalier, Connie H.Y. Wong, Laurence Macia
Publikováno v:
Arthritis & Rheumatology. 68:1026-1038
ObjectiveAntibody-mediated autoimmunity involves cognate interactions between self-reactive T cells and B cells during germinal center (GC) reactions. The aim of this study was to determine the role of essential follicular helper T (Tfh) cell molecul
Autor:
Weng Hua Khoo, Mark Read, Gary Gracie, Robert Brink, Andrew Parker, Katherine Bourne, John Zaunders, Anthony D. Kelleher, Stuart G. Tangye, Tri Giang Phan, Maté Biro, Cindy S. Ma, Imogen Moran, C Mee Ling Munier, Danyal Butt, Akira Nguyen, Clara Young, Peter I. Croucher, Jana R. Hermes, Fabio Luciani
Publikováno v:
Cellular and Molecular Immunology
Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Vaccine-induced immunity depends on the generation of memory B cells (MBC). However, where and how MBCs are reactivated to make neutralising antibodies remain unknown. Here we show that MBCs are prepositioned in a subcapsular niche in lymph nodes whe
Autor:
Peter R. Schofield, Benjamin T. Porebski, Robert Brink, Deborah L. Burnett, Kate I. Patterson, Tyani D. Chan, Jennifer Jackson, Christopher C. Goodnow, Joanne H. Reed, Daniel Christ, David B. Langley, Katherine Bourne, Jana R. Hermes
Autoantibody redemption through rapid mutations Antibodies distinguish foreign epitopes from closely related self-antigens by poorly understood mechanisms. In mice, Burnett et al. found that a proportion of B cells could cross-react with similar fore
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c96d5ab216267f6b749c288a31e8018
https://europepmc.org/articles/PMC5922412/
https://europepmc.org/articles/PMC5922412/
Autor:
Katherine Bourne, Danyal Butt, Antony Basten, Cindy S. Ma, Akira Nguyen, Andreas Strasser, Susan Price, Jana R. Hermes, Peter R. Schofield, Tyani D. Chan, Daniel Christ, Robert Brink, Aaron L. Statham, V. Koneti Rao, Lorraine A. O'Reilly, Stuart G. Tangye, Tri Giang Phan
Publikováno v:
Immunity. 42(5):890-902
SummaryThe mechanistic links between genetic variation and autoantibody production in autoimmune disease remain obscure. Autoimmune lymphoproliferative syndrome (ALPS) is caused by inactivating mutations in FAS or FASL, with autoantibodies thought to
Autor:
Dan Suan, Stuart G. Tangye, Elissa K. Deenick, Henry R. Hampton, Katherine Bourne, Anthony D. Kelleher, Yoshihiro Miwa, Robert Brink, Akira Nguyen, Warren Kaplan, Tatyana Chtanova, Tri Giang Phan, Mehreen Arshi, Michio Tomura, Imogen Moran, Jana R. Hermes
Publikováno v:
Immunity. 42:704-718
SummaryB helper follicular T (Tfh) cells are critical for long-term humoral immunity. However, it remains unclear how these cells are recruited and contribute to secondary immune responses. Here we show that primary Tfh cells segregate into follicula