Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Katherine Bortoff"'
Autor:
Alan Fulp, Timothy R. Fennell, James M. Mathews, Yanan Zhang, Rodney W. Snyder, Herbert Seltzman, Rangan Maitra, Katherine Bortoff
Publikováno v:
Journal of Medicinal Chemistry. 55:10022-10032
Cannabinoid receptor 1 (CB1) antagonists are potentially useful for the treatment of several diseases. However, clinical development of several CB1 antagonists was halted due to central nervous system (CNS)-related side effects including depression a
Autor:
Vineetha Vasukuttan, Yanyan Zhang, Jeffery R. Deschamps, Scott P. Runyon, Rangan Maitra, James B. Thomas, Ann M. Decker, Sanju Narayanan, Katherine Bortoff, Keith R. Warner
Publikováno v:
Bioorganicmedicinal chemistry. 24(16)
The apelinergic system includes a series of endogenous peptides apelin, ELABELA/TODDLER and their 7-transmembrane G-protein coupled apelin receptor (APJ, AGTRL-1, APLNR). The APJ receptor is an attractive therapeutic target because of its involvement
Publikováno v:
Hypertension in Pregnancy. 31:398-404
Preeclampsia is a hypertensive disorder that complicates 3-7% of pregnancies. The development of preeclampsia has not been completely elucidated and current therapies are not broadly efficacious. The apelinergic system appears to be involved in hyper
Autor:
George S. Amato, Herbert H. Seltzman, Robert W. Wiethe, Rangan Maitra, Katherine Bortoff, Yanan Zhang, Rodney W. Snyder, Alan Fulp
Publikováno v:
Bioorganicmedicinal chemistry. 24(5)
Type 1 cannabinoid receptor (CB1) antagonists might be useful for treating obesity, liver disease, metabolic syndrome, and dyslipidemias. Unfortunately, inhibition of CB1 in the central nervous system (CNS) produces adverse effects, including depress
Autor:
Yanan Zhang, Alan Fulp, Herbert H. Seltzman, Katherine Bortoff, Rodney W. Snyder, Rangan Maitra
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(19)
CB1 receptor antagonists that are peripherally restricted were targeted. Compounds with permanent charge as well as compounds that have increased polar surface area were made and tested against CB1 for binding and activity. Sulfonamide and sulfamide