Výsledky vyhledávání - "Katherine A.B. Kellett"

Proteolysis of the low‐density lipoprotein receptor in hepatocytes is mediated by BMP1 but not by other astacin proteases

Autor: Katherine A.B. Kellett, Kate Fisher, Harry Aldworth, Nigel M. Hooper

Publikováno v: Kellett, K A B, Fisher, K, Aldworth, H & Hooper, N M 2023, ' Proteolysis of the low-density lipoprotein receptor in hepatocytes is mediated by BMP1 but not by other astacin proteases ', FEBS Letters . https://doi.org/10.1002/1873-3468.14667

Bone morphogenetic protein 1 (BMP1), a member of the astacin family of zinc-metalloproteases, proteolytically cleaves the low-density lipoprotein receptor (LDLR) within its ligand-binding domain, reducing the binding and cellular uptake of LDL-choles

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fce982c2fbbb56f153f64aca254f879
https://doi.org/10.1002/1873-3468.14667

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The role of protein aggregation in the pathogenesis of inclusion body myositis

Autor: Andrew M. Snedden, Katherine A.B. Kellett, James B. Lilleker, Nigel M. Hooper, Hector Chinoy

Publikováno v: Clinical and experimental rheumatology. 40(2)

Inclusion body myositis (IBM) is characterised by infiltration of CD8+ T-cells and signs of protein aggregation such as rimmed vacuoles and inclusion bodies. Aggregated proteins include those present in neurodegenerative diseases, and also those invo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f11d75472fd0157e202851317f8964f
https://pubmed.ncbi.nlm.nih.gov/35225225

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Discovery of Biphenylacetamide-Derived Inhibitors of BACE1 Using de Novo Structure-Based Molecular Design

Autor: N. Yi Mok, James Chadwick, Nigel M. Hooper, Colin W. G. Fishwick, Katherine A.B. Kellett, A. Peter Johnson, Eva Casas-Arce

Publikováno v: Journal of Medicinal Chemistry. 56:1843-1852

β-Secretase (BACE1), the enzyme responsible for the first and rate-limiting step in the production of amyloid-β peptides, is an attractive target for the treatment of Alzheimer's disease. In this study, we report the application of the de novo frag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87eee5b0f246f6a91d3234516d2b3306
https://doi.org/10.1021/jm301127x

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Prion Protein Interacts with BACE1 Protein and Differentially Regulates Its Activity toward Wild Type and Swedish Mutant Amyloid Precursor Protein

Autor: Herbert Baybutt, Isobel J. Whitehouse, Jean Manson, Debbie Brown, Pedro Piccardo, Anthony J. Turner, Carolyn D. Jackson, Heledd H. Griffiths, Nigel M. Hooper, Katherine A.B. Kellett

Publikováno v: Griffiths, H H, Whitehouse, I J, Baybutt, H, Brown, D, Kellett, K A, Jackson, C D, Turner, A J, Piccardo, P, Manson, J C & Hooper, N M 2011, ' Prion protein interacts with bace1 and differentially regulates its activity towards wild type and swedish mutant amyloid precursor protein ', Journal of Biological Chemistry, vol. 286, no. 38, pp. 33489-33500 . https://doi.org/10.1074/jbc.M111.278556

In Alzheimer disease amyloid-β (Aβ) peptides derived from the amyloid precursor protein (APP) accumulate in the brain. Cleavage of APP by the β-secretase BACE1 is the rate-limiting step in the production of Aβ. We have reported previously that th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a495d596c0a192d64f5998d8bc4cfc7
https://doi.org/10.1074/jbc.m111.278556

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The Transcriptionally Active Amyloid Precursor Protein (APP) Intracellular Domain Is Preferentially Produced from the 695 Isoform of APP in a β-Secretase-dependent Pathway

Autor: Natalia Z. Makova, Nigel M. Hooper, Katherine A.B. Kellett, Natalia N. Nalivaeva, Anthony J. Turner, Nikolai D. Belyaev, Caroline Beckett, Timothy J. Revett

Publikováno v: Journal of Biological Chemistry. 285:41443-41454

Amyloidogenic processing of the amyloid precursor protein (APP) by β- and γ-secretases generates several biologically active products, including amyloid-β (Aβ) and the APP intracellular domain (AICD). AICD regulates transcription of several neuro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39ad22a1e2758250554edf85fbc71b3f
https://doi.org/10.1074/jbc.m110.141390

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Discovery of novel non-peptide inhibitors of BACE-1 using virtual high-throughput screening

Autor: Colin W. G. Fishwick, James Chadwick, Nigel M. Hooper, A. Peter Johnson, N. Yi Mok, Katherine A.B. Kellett

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 19:6770-6774

A novel series of isatin-based inhibitors of beta-secretase (BACE-1) have been identified using a virtual high-throughput screening approach. Structure-activity relationship studies revealed structural features important for inhibition. Docking studi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1e85276a9f8e0dbacdf58c816fc4735
https://doi.org/10.1016/j.bmcl.2009.09.103

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Prion protein and Alzheimer disease

Autor: Nigel M. Hooper, Katherine A.B. Kellett

Publikováno v: Prion. 3:190-194

Alzheimer and prion diseases are neurodegenerative disorders characterised by the abnormal processing of amyloid-beta (Abeta) peptide and prion protein (PrP(C)), respectively. Recent evidence indicates that PrP(C) may play a critical role in the path

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0311b30758a6fb6443455fae1dc3c3c
https://doi.org/10.4161/pri.3.4.9980

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