Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Katherine A. Overmyer"'
Autor:
Hiroyuki Mori, Sydney K. Peterson, Rachel C. Simmermon, Katherine A. Overmyer, Akira Nishii, Emma Paulsson, Ziru Li, Annie Jen, Romina M. Uranga, Jessica N. Maung, Warren T. Yacawych, Kenneth T. Lewis, Rebecca L. Schill, Taryn Hetrick, Ryo Seino, Ken Inoki, Joshua J. Coon, Ormond A. MacDougald
Publikováno v:
Molecular Metabolism, Vol 83, Iss , Pp 101916- (2024)
Objective: Exposure of adipocytes to ‘cool’ temperatures often found in the periphery of the body induces expression of Stearoyl-CoA Desaturase-1 (Scd1), an enzyme that converts saturated fatty acids to monounsaturated fatty acids. The goal of th
Externí odkaz:
https://doaj.org/article/f76e22ea51ec4cc08977dd19997e3c5d
Autor:
Ruiqi Liao, Abiola Babatunde, Stephanie Qiu, Hamsini Harikumar, Joshua J. Coon, Katherine A. Overmyer, Yusuf A. Hannun, Chiara Luberto, Emery H. Bresnick
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Transcriptional mechanisms controlling developmental processes establish and maintain proteomic networks, which can govern the levels of intracellular small molecules. Although dynamic changes in bioactive small molecules can link transcript
Externí odkaz:
https://doaj.org/article/13af0e79e3c44252bf0bbbf743e9c8b7
Autor:
Gonzalo Fernandez-Fuente, Katherine A. Overmyer, Alexis J. Lawton, Ildiko Kasza, Samantha L. Shapiro, Patricia Gallego-Muñoz, Joshua J. Coon, John M. Denu, Caroline M. Alexander, Luigi Puglielli
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-17 (2023)
Abstract Cytosolic citrate is imported from the mitochondria by SLC25A1, and from the extracellular milieu by SLC13A5. In the cytosol, citrate is used by ACLY to generate acetyl-CoA, which can then be exported to the endoplasmic reticulum (ER) by SLC
Externí odkaz:
https://doaj.org/article/431bd0466cac4c12b1c6a4333e671895
Autor:
Mats W. Johansson, Joseph Balnis, Laura K. Muehlbauer, Yury V. Bukhman, Matthew S. Stefely, Katherine A. Overmyer, Rachel Vancavage, Anupama Tiwari, Anish Raj Adhikari, Paul J. Feustel, Bradford S. Schwartz, Joshua J. Coon, Ron Stewart, Ariel Jaitovich, Deane F. Mosher
Publikováno v:
Physiological Reports, Vol 11, Iss 17, Pp n/a-n/a (2023)
Abstract Cartilage acidic protein‐1 (CRTAC1) is produced by several cell types, including Type 2 alveolar epithelial (T2AE) cells that are targeted by SARS‐CoV2. Plasma CRTAC1 is known based on proteomic surveys to be low in patients with severe
Externí odkaz:
https://doaj.org/article/c1f11d90a5054294aa369231a2511ab9
Autor:
Sarvada Chipkar, Katherine Smith, Elizabeth M. Whelan, Derek J. Debrauske, Annie Jen, Katherine A. Overmyer, Andrea Senyk, Larkin Hooker-Moericke, Marissa Gallmeyer, Joshua J. Coon, A. Daniel Jones, Trey K. Sato, Rebecca G. Ong
Publikováno v:
Biotechnology for Biofuels and Bioproducts, Vol 15, Iss 1, Pp 1-16 (2022)
Abstract Background Developing economically viable pathways to produce renewable energy has become an important research theme in recent years. Lignocellulosic biomass is a promising feedstock that can be converted into second-generation biofuels and
Externí odkaz:
https://doaj.org/article/af0587b3e1f74cacba85c570e5ba2cd6
Autor:
Hankum Park, Frances V. Hundley, Qing Yu, Katherine A. Overmyer, Dain R. Brademan, Lia Serrano, Joao A. Paulo, Julia C. Paoli, Sharan Swarup, Joshua J. Coon, Steven P. Gygi, J. Wade Harper
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
Methods to assess organellar content are important. Here, Park et al develop a method for rapid isolation of early/sorting endosomes and demonstrate the application of the approach for analysis of endosomal proteomes and lipidomes, and for analysis o
Externí odkaz:
https://doaj.org/article/1a034683ce2a4dcfbf3aa019ef9440d8
Autor:
Arwen W. Gao, Gaby El Alam, Amélia Lalou, Terytty Yang Li, Marte Molenaars, Yunyun Zhu, Katherine A. Overmyer, Evgenia Shishkova, Kevin Hof, Maroun Bou Sleiman, Riekelt H. Houtkooper, Joshua J. Coon, Johan Auwerx
Publikováno v:
iScience, Vol 25, Iss 2, Pp 103734- (2022)
Summary: The mitochondrial unfolded protein response (UPRmt) is a promising pharmacological target for aging and age-related diseases. However, the integrative analysis of the impact of UPRmt activation on different signaling layers in animals with d
Externí odkaz:
https://doaj.org/article/bacd3afe777e47c39fb1890b101a8dd9
Autor:
Inca A. Dieterich, Alexis J. Lawton, Yajing Peng, Qing Yu, Timothy W. Rhoads, Katherine A. Overmyer, Yusi Cui, Eric A. Armstrong, Porsha R. Howell, Maggie S. Burhans, Lingjun Li, John M. Denu, Joshua J. Coon, Rozalyn M. Anderson, Luigi Puglielli
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
The Endoplasmic Reticulum acetylation machinery ensures proper quality control and disposal of newly folded proteins transiting the secretory pathway. Here, the authors show that this machinery acts as a metabolic regulator of acetyl-CoA homeostasis,
Externí odkaz:
https://doaj.org/article/0d4577b03c594bb194303bbedd2c9a54
Autor:
Natalie M. Niemi, Gary M. Wilson, Katherine A. Overmyer, F.-Nora Vögtle, Lisa Myketin, Danielle C. Lohman, Kathryn L. Schueler, Alan D. Attie, Chris Meisinger, Joshua J. Coon, David J. Pagliarini
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
The mitochondria houses several phosphatases, but their function is not well characterized. Here, the authors show that mitochondrial phosphatase Pptc7 is important during development for proper mitochondrial function and has a role regulating protei
Externí odkaz:
https://doaj.org/article/0cc3120d036a46b9807f1cae4a084aeb
Severe COVID-19 Shares a Common Neutrophil Activation Signature with Other Acute Inflammatory States
Autor:
Lena F. Schimke, Alexandre H. C. Marques, Gabriela Crispim Baiocchi, Caroline Aliane de Souza Prado, Dennyson Leandro M. Fonseca, Paula Paccielli Freire, Desirée Rodrigues Plaça, Igor Salerno Filgueiras, Ranieri Coelho Salgado, Gabriel Jansen-Marques, Antonio Edson Rocha Oliveira, Jean Pierre Schatzmann Peron, Gustavo Cabral-Miranda, José Alexandre Marzagão Barbuto, Niels Olsen Saraiva Camara, Vera Lúcia Garcia Calich, Hans D. Ochs, Antonio Condino-Neto, Katherine A. Overmyer, Joshua J. Coon, Joseph Balnis, Ariel Jaitovich, Jonas Schulte-Schrepping, Thomas Ulas, Joachim L. Schultze, Helder I. Nakaya, Igor Jurisica, Otávio Cabral-Marques
Publikováno v:
Cells, Vol 11, Iss 5, p 847 (2022)
Severe COVID-19 patients present a clinical and laboratory overlap with other hyperinflammatory conditions such as hemophagocytic lymphohistiocytosis (HLH). However, the underlying mechanisms of these conditions remain to be explored. Here, we invest
Externí odkaz:
https://doaj.org/article/5d38a95098184123904d7717c0fac886