Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Katherine A. Minson"'
Autor:
Katherine A. Minson, Pinki Prasad, Susan Vear, Scott Borinstein, Richard Ho, Jennifer Domm, Haydar Frangoul
Publikováno v:
Case Reports in Hematology, Vol 2013 (2013)
Several cytogenetic abnormalities identified in patients with childhood acute lymphocytic leukemia (ALL) have been associated with a poor prognosis. There are several case reports in the literature describing t(17;19) in children with ALL. This trans
Externí odkaz:
https://doaj.org/article/6fca80804d0d4e49aa61a9a7ee0fe2cf
Autor:
Douglas K. Graham, Deborah DeRyckere, H. Shelton Earp, Stephen V. Frye, Xiaodong Wang, S. Gail Eckhardt, Tal Burstyn-Cohen, Rotem Kami, William A. Robinson, Stacey M. Bagby, Jacqueline Carrico, John J. Tentler, Katherine A. Minson, Lenka Sinik
Supplemental Figure 3 shows impact of UNC2025 on cell viability.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::539ee40d58bff3838b818555a378ef59
https://doi.org/10.1158/1535-7163.22508881
https://doi.org/10.1158/1535-7163.22508881
Autor:
Douglas K. Graham, Deborah DeRyckere, H. Shelton Earp, Stephen V. Frye, Xiaodong Wang, S. Gail Eckhardt, Tal Burstyn-Cohen, Rotem Kami, William A. Robinson, Stacey M. Bagby, Jacqueline Carrico, John J. Tentler, Katherine A. Minson, Lenka Sinik
Supplemental Figure 2 shows impact of UNC2025 on colony forming potential.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13be068ca67762efe397a83c5d6586b8
https://doi.org/10.1158/1535-7163.22508884.v1
https://doi.org/10.1158/1535-7163.22508884.v1
Autor:
Douglas K. Graham, Deborah DeRyckere, H. Shelton Earp, Stephen V. Frye, Xiaodong Wang, S. Gail Eckhardt, Tal Burstyn-Cohen, Rotem Kami, William A. Robinson, Stacey M. Bagby, Jacqueline Carrico, John J. Tentler, Katherine A. Minson, Lenka Sinik
Supplemental Figure 4 shows TAM-family kinase expression in melanoma cell lines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e925147742d72fe1c33fb2b661b6de5
https://doi.org/10.1158/1535-7163.22508878.v1
https://doi.org/10.1158/1535-7163.22508878.v1
Autor:
Douglas K. Graham, Deborah DeRyckere, H. Shelton Earp, Stephen V. Frye, Xiaodong Wang, S. Gail Eckhardt, Tal Burstyn-Cohen, Rotem Kami, William A. Robinson, Stacey M. Bagby, Jacqueline Carrico, John J. Tentler, Katherine A. Minson, Lenka Sinik
Supplemental Figure 7 shows combined UNC2025 and vemurafenib treatment is tolerated in mice.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c0f86e0d658bf7d6c2c993a7e001fa5
https://doi.org/10.1158/1535-7163.22508869
https://doi.org/10.1158/1535-7163.22508869
Autor:
Douglas K. Graham, Deborah DeRyckere, H. Shelton Earp, Stephen V. Frye, Xiaodong Wang, S. Gail Eckhardt, Tal Burstyn-Cohen, Rotem Kami, William A. Robinson, Stacey M. Bagby, Jacqueline Carrico, John J. Tentler, Katherine A. Minson, Lenka Sinik
Supplemental Figures 6 shows efficacy of UNC2025 in a melanoma wild-type PDX mode.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2398d7944e7ed6dcf6d65edd0eabc5f
https://doi.org/10.1158/1535-7163.22508872.v1
https://doi.org/10.1158/1535-7163.22508872.v1
Autor:
Justus M. Huelse, Dehui Zhang, Michael J. Miley, Rebecca E. Parker, Chenxiao Da, Lee M. Graves, H. Shelton Earp, Stephen V. Frye, Madeline G. Huey, Laura E. Herring, Dmitri Kireev, Xiaodong Wang, Michael A. Stashko, Douglas K. Graham, Jacqueline Norris-Drouin, Thomas S. K. Gilbert, Katherine A. Minson, Deborah DeRyckere, Debra Hunter, Eleana Vasileiadi
Publikováno v:
J Am Chem Soc
Controlling which particular members of a large protein family are targeted by a drug is key to achieving a desired therapeutic response. In this study, we report a rational data-driven strategy for achieving restricted polypharmacology in the design
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a56601afc98511d1e107788dc4625c46
https://doi.org/10.1021/jacs.9b08660
https://doi.org/10.1021/jacs.9b08660
Autor:
Jacqueline Carrico, Katherine A. Minson, Stephen V. Frye, Rotem Kami, S. Gail Eckhardt, John J. Tentler, Douglas K. Graham, Tal Burstyn-Cohen, Stacey M. Bagby, Deborah DeRyckere, Lenka Sinik, H. Shelton Earp, Xiaodong Wang, William A. Robinson
Publikováno v:
Mol Cancer Ther
Molecularly-targeted agents have improved outcomes for a subset of patients with BRAF-mutated melanoma, but treatment of resistant and BRAF wild-type tumors remains a challenge. The MERTK receptor tyrosine kinase is aberrantly expressed in melanoma a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07e1c89f4894b87191292bb039851452
https://doi.org/10.1158/1535-7163.mct-18-0456
https://doi.org/10.1158/1535-7163.mct-18-0456
Autor:
Katherine A. Minson, Todd M. Cooper, Kristen E Allen, Caitlin Monroe, Frank G. Keller, Jonathan Metts, Himalee S. Sabnis, Sharon M. Castellino, William G. Woods
Publikováno v:
Leukemia research. 96
Background Advances in risk stratification have improved the 3-year disease-free survival (DFS) and overall survival (OS) of low-risk pediatric acute myeloid leukemia (LR-AML) to approximately 70 % and 85 % respectively. LR-AML is defined by favorabl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::737f2e636865c6f2d2eaf2ce7d830a18
https://pubmed.ncbi.nlm.nih.gov/32683126
https://pubmed.ncbi.nlm.nih.gov/32683126
Autor:
Deborah DeRyckere, Katina M. Wilson, Brian R. Branchford, J. Di Paola, Gilbert Acevedo, Pavel Davizon-Castillo, Douglas K. Graham, Katherine A. Minson, Keith B. Neeves, Alisa B. Lee-Sherick, Christine Brzezinski, L. Law, Steven R. Lentz, Weihe Zhang, Xiaodong Wang, Timothy J. Stalker, H. Shelton Earp, Lawrence F. Brass, Stephen V. Frye, Christopher J. Ng, Susan Sather
Publikováno v:
Journal of Thrombosis and Haemostasis. 16:352-363
Essentials Signaling by Gas6 through Tyro3/Axl/Mer receptors is essential for stable platelet aggregation. UNC2025 is a small molecule inhibitor of the Mer tyrosine kinase. UNC2025 decreases platelet activation in vitro and thrombus formation in vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e745ea8a38cf239901e8f4d9bf33229e
https://doi.org/10.1111/jth.13875
https://doi.org/10.1111/jth.13875