Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Katherine A. Henzler-Wildman"'
Autor:
Peyton J. Spreacker, Nathan E. Thomas, Will F. Beeninga, Merissa Brousseau, Colin J. Porter, Kylie M. Hibbs, Katherine A. Henzler-Wildman
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Antibiotic resistance through multidrug efflux is a major hurdle in antibiotic development. Here, authors experimentally demonstrate that EmrE, a small multidrug resistance efflux pump from E. coli, can confer resistance or susceptibility depending o
Externí odkaz:
https://doaj.org/article/78d3e70700c04c05bf5b159674cdf840
Autor:
Alexander A. Shcherbakov, Peyton J. Spreacker, Aurelio J. Dregni, Katherine A. Henzler-Wildman, Mei Hong
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
EmrE transporter effluxes cationic substrates across lipid membranes in a pH-coupled manner. Here, the authors solve the structure of ligand-bound EmrE at high pH by NMR, with insights into the transport mechanism.
Externí odkaz:
https://doaj.org/article/a6ff24e0a3844b76b2840e90afda18df
Autor:
Alexander A. Shcherbakov, Grant Hisao, Venkata S. Mandala, Nathan E. Thomas, Mohammad Soltani, E. A. Salter, James H. Davis, Katherine A. Henzler-Wildman, Mei Hong
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
The small proton-coupled transporter EmrE confers multidrug resistance in bacteria. The structure of drug-bound EmrE in phospholipid bilayers is now determined using solid-state NMR. The structure provides detailed insights into the molecular mechani
Externí odkaz:
https://doaj.org/article/db0829dbaea348d0bf08d38e1f44870d
Publikováno v:
Journal of the American Chemical Society. 145:10104-10115
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::359585869f67e94facc2ef3d8aec1b3d
https://doi.org/10.1021/jacs.3c00340
https://doi.org/10.1021/jacs.3c00340
Autor:
Peyton J. Spreacker, Colin J. Porter, Andrea Wegrzynowicz, Will F. Beeninga, Sydnye Demas, Emma N. Powers, Katherine A. Henzler-Wildman
Small multidrug resistance (SMR) transporters efflux toxic substrates from bacterial cells and were recently divided into two subfamilies: specific toxic metabolite transporters and promiscuous drug exporters. These drug exporters are thought to func
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f0197d6bb622f81dd62566f2645fccb
https://doi.org/10.1101/2022.11.22.517605
https://doi.org/10.1101/2022.11.22.517605
Autor:
Peyton J. Spreacker, Merissa Brousseau, Grant S. Hisao, Mohammad Soltani, James H. Davis, Katherine A. Henzler-Wildman
Publikováno v:
The Journal of biological chemistry.
EmrE, a small multidrug resistance (SMR) transporter from E. coli, confers broad-spectrum resistance to polyaromatic cations and quaternary ammonium compounds. Previous transport assays demonstrate that EmrE transports a +1 and a +2 substrate with th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adc54862079ef6349cefd314957a56d7
https://pubmed.ncbi.nlm.nih.gov/36529287
https://pubmed.ncbi.nlm.nih.gov/36529287
Autor:
Peyton J. Spreacker, Merissa Brousseau, Grant S. Hisao, Mohammad Soltani, James H. Davis, Katherine A. Henzler-Wildman
EmrE, a small multidrug resistance (SMR) transporter from E. coli, confers broad-spectrum resistance to polyaromatic cations and quaternary ammonium compounds. Previous transport assays demonstrate that EmrE transports a +1 and a +2 substrate with th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c0e45b99490bd2080b78a2de464f0489
https://doi.org/10.1101/2022.08.17.503475
https://doi.org/10.1101/2022.08.17.503475
Autor:
Chad M. Rienstra, Thomas K. Anderson, Rob Kirchdoerfer, Katherine A. Henzler-Wildman, Marco Tonelli
Publikováno v:
Biomolecular NMR Assignments
Biomolecular Nmr Assignments
Biomolecular Nmr Assignments
The SARS-CoV-2 genome encodes for approximately 30 proteins. Within the international project covid19-nmr, we distribute the spectroscopic analysis of the viral proteins and RNA. Here, we report NMR chemical shift assignments for the protein nsp7. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3d4f00af091c377ed7b09cc2a85501f
https://doi.org/10.1007/s12104-020-09985-0
https://doi.org/10.1007/s12104-020-09985-0
Publikováno v:
Biophysical Journal. 122:519a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3adb9452d05438da0347251e7378188d
https://doi.org/10.1016/j.bpj.2022.11.2760
https://doi.org/10.1016/j.bpj.2022.11.2760